by Elisabeth Paymal One of the hallmarks of ovarian cancer is genomic instability resulting in gain and loss of DNA throughout the entire genome, including many microRNAs (miRNA). Dr. DiFeo, Ph.D., Associate Professor of Pathology and of Obstetrics and Gynecology at Michigan Medicine, and her team, research which miRNAs are involved in the early stages…
Keane is U-M’s 15th scientist to receive this very prestigious award since its inauguration in 1985, and the first one since 2013. “For my lab what this award means is that we can take real chances and pursue these challenging projects that are really difficult in terms of methodology development and other technical challenges that…
Sarah Keane, Ph.D. Assistant Professor of Biophysics, William R. Roush Assistant Professor of Chemistry Biophysics and Department of Chemistry College of LSA https://sites.lsa.umich.edu/keane-lab/ @KeaneLab The Keane’s lab is interested in understanding how RNA molecules fold and how their three-dimensional structures impact function. RNAs play a number of different regulatory roles in health and disease…
May 27 2:00–4:00 pm, Concurrent Session 2, RNA Structure and Regulation Adrien Chauvier, Pujan Ajmera, Nils Walter, Competition between ligand binding and transcription factor NusA modulates riboswitch-mediated regulation of transcription 8:00–9:00 pm, Poster Session 2, Interconnected Processes Catherine Scull, The N-terminal region of the A12.2 subunit stimulates RNA polymerase I transcription elongation 9:00–10:00 pm, Poster Session 5, RNA…
The RNA Collaborative seminar series goal is to cross promote RNA research and strengthen and connect the RNA scientific community. More information is available on the RNA Collaborative Seminar Series webpage, supported by The RNA Society. We encourage RNA Centers across the world to join us. If your RNA Center is interested in joining this…
Launched in April 2020, the goal of the RNA Collaborative seminar series is to cross-promote RNA research to strengthen and connect the RNA scientific community. Proposed by the University of Michigan (U-M) Center for RNA Biomedicine, this initiative received great enthusiasm from seven RNA research centers. The group was quickly joined by two more centers…
The election of professors Janet L. Smith and Arul Chinnaiyan, both members of the Center for RNA Biomedicine Strategic Advisory Board, to the National Academy of Sciences is an outstanding validation of the excellence of the RNA research at the University of Michigan. Members are elected to the National Academy of Sciences in recognition of…
“Martina Jerant is brimming with energy, big ideas and “outside the box” thinking, which has been instrumental in achieving the Center for RNA Biomedicine’s mission to build bridges across our large campus through a broad range of activities that Martina handles essentially on her own, with little input from us, and all extraordinarily competently,” wrote…
Wednesday, May 6, 2020, 4:00-5:00 Eastern Time Zoom link Hosted by the University of Michigan Center for RNA Biomedicine It’s not the gene, it’s the neighborhood: Effects of large scale chromosomal structure on bacterial transcription Peter Freddolino, Ph.D. Assistant Professor, Biological Chemistry and Computational Medicine & Bioinformatics Member of the Center for RNA Biomedicine Executive…
The grassroots Center for RNA Biomedicine at the University of Michigan involves among its opt-in membership RNA scientists from across the Ann Arbor campus, encompassing all seven Schools and Colleges that are engaged in the Biosciences. The Center’s leadership reflects this diversity of viewpoints and serves to facilitate scientific collaboration.
By Elisabeth Paymal, Center for RNA Biomedicine As soon as COVID-19 information was released, RNA biologist and child neurologist Dr. Vivian Cheung looked at what was known about this new RNA virus. “What I saw was amazingly surprising: the RNA of the virus encodes a familiar protein, the one that I’ve studied for years in…
Markos Koutmos, Ph.D. Assistant Professor of Biophysics & Chemistry Markos Koutmos joined the Center’s Executive Committee in 2020. The Koutmos lab is interested in understanding how the 3D structure and dynamics of proteins and RNAs drive their biological function. His lab combines chemistry, biophysics and biology approaches to build a foundation of basic knowledge for…
by Dr. Kretzler and his team, and Elisabeth Paymal, U-M Center for RNA Biomedicine The scientific response to the COVID-19 pandemic is rapidly evolving. Every day, scientists are making discoveries based on years of investment in training and expertise that resulted in the accumulation of large, shared, high quality data sets now ready to be…
By Adam Diehl, Alan Boyle, and Elisabeth Paymal, Center for RNA Biomedicine Until recently, little was known about how transposable elements contribute to gene regulation. These are little pieces of DNA that can replicate themselves and spread out in the genome. Although they make up nearly half of the human genome, these were often ignored…
The Center for RNA Biomedicine offers bi-weekly RNA Innovation Seminars that feature visiting professors, U of M faculty, and students. The seminars cover a broad array of topics about RNA research and its application. In addition to learning about the latest research in the field, it is an opportunity to meet colleagues, network, and foster…
Dr. Stephanie Moon is Assistant Professor in the Department of Human Genetics at the University of Michigan (U-M) Medical School, and a faculty scholar at the U-M Center for RNA Biomedicine. She joined our RNA community in January 2020, and is the first RNA BSI faculty hire. Dr. Moon brings to Michigan an extensive experience…
The cell is a complex network of interacting components, or molecules, each of them with its own characteristics and all of them together functioning as a living system. Each of the molecular processes and interactions in the cell bears the risk of becoming dysfunctional, resulting in disease. Biomedical research into processes that power the cell…
Over half of our genomes are made of repeating elements within DNA. In rare cases, these repeats can become unstable and grow in size. These repeat “expansions” cause neurodegenerative diseases such as ALS and Dementia as well as learning disorders and autism in Fragile X syndrome. Research to date has focused on how these expanded…
Amanda Garner, Ph.D. Assistant Professor Department of Medicinal Chemistry The Garner Laboratory is developing novel high-throughput screening assays for the discovery of chemical probes for targeting microRNAs and microRNA-microRNA-binding protein interactions. In addition, we are engaged in the discovery of new microRNA-binding proteins using chemical biology and proteomic approaches. Visit Lab Website Follow on Twitter:…
Ian Hall Graduate Student Keane Lab Department of Chemistry Who/what brought you to science? I had excellent mentors in high school and college that encouraged me to pursue science. What are your research interests? I study the structure and function of regulatory RNAs. I am interested in the molecular mechanisms by which RNA…
