| First Name | Last Name | Unit/College | Department | Research Description | |
|---|---|---|---|---|---|
| Carlos | Aguilar | Engineering | Biomedical Engineering | The long-term goal of the NOBEL is to make breakthroughs in medicine and biology that instill hope and inspire others. To accomplish this feat, we develop, optimize and apply innovative technologies such as integrative genomic assays and high-throughput sequencing, micro/nanofabricated devices, genome editing and computational modeling to our primary area of focus, which is skeletal muscle. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Huda | Akil | Medical School | Molecular & Behav Neurosci Inst | Research in the Akil laboratory is focused on understanding the neurobiology of emotions, including pain, anxiety, depression and substance abuse. Early on, our research focused on the role of the endorphins and their receptors in pain and stress responsiveness. We provided the first physiological evidence for a role of endogenous opioids in the brain; and showed that endorphins are activated by stress and cause pain inhibition, a phenomenon we termed Stress-Induced Analgesia. We defined how the posttranslational processing of opioid precursors is modulated by stress, and demonstrated the coordinate actions of the neuropeptide products on behavior. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Benjamin | Allen | Medical School | Cell & Dev Biology | Research in the Allen Lab is broadly focused on understanding the mechanisms of growth factor and morphogen signaling in development and disease. Specifically, we study the regulation of Hedgehog (Hh) signaling during vertebrate embryogenesis using a wide range of approaches, including mouse developmental genetics, chick in ovo electroporation, biochemistry, and cell biology. The long-term goal of our research is to use insights gained from the study of Hh signaling in normal development in the treatment of a broad spectrum of developmental diseases and childhood and adult cancers. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Joshi | Alumkal | Medical School | Int Med | The Alumkal Laboratory’s main emphasis is to understand how genomic and epigenomic changes contribute to lethal prostate cancer progression. We use biochemical, genomic, and epigenomic approaches in cellular models to clarify mechanisms by which key transcriptional regulators function. The most important goals of our studies are to identify therapies that effectively target and interdict lethal prostate cancer progression and to conduct innovative clinical trials designed to validate the molecular and clinical effectiveness of novel therapeutic agents. Visit Lab Website View Altmetric Attention Highlights | |
| Anthony | Antonellis | Medical School | Human Genetics | Our group is broadly interested in how human genetic variation affects gene and genome function. One area of research is grounded in the observation that mutations in aminoacyl-tRNA synthetases cause myriad disease phenotypes including dominant axonal neuropathy and recessive syndromes that include neurodevelopmental defects. A second area of research aims to study how gene regulation—via cis-acting transcriptional regulatory elements including enhancers and promoters—plays a role in the development of myelinating cells of the peripheral and central nervous systems. We are always looking for outstanding students and post-doctoral fellows to advance each of these areas. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Brian | Athey | Medical School | Comp Med and Bioinformatics | One main area of research is the application of high resolution fluorescence optical microscopy coupled with high-throughput analysis, 3D imaging and machine learning to explore the chromatin structure and nuclear architecture of cells. This research emphasizes the convergence between 3D structural predictions and 3D structural measurements with microscopy, to provide insight into the transcriptional architecture of the interphase nucleus. The next area of research centers on the exploration of the pharmacoepigenome in psychiatry, neurology, anesthesia and addiction medicine. This research employs high-throughput 4D microscopic imaging of enhancers, promoters and chromatin features, using fluorescence in situ hybridization (FISH). These methods are coupled with Hi-C chromatin conformation capture, chromatin state annotation, localization in postmortem human brain tissue and induced neuronal pluripotent stem cells, and machine learning for identification of regulatory variants, to provide insight into the genetic and epigenetic mechanisms of inter-individual and inter-cohort differences in psychotropic drug response. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Sara Jo | Aton | LSA | MCDB | Brain states such as sleep and wakefulness have a profound impact on mRNA transcription and translation. Research in the Aton lab characterizes how sleep contributes to transcription and translation of mRNAs in different cell types of the central nervous system, how these processes affect learning and memory consolidation, and how they are affected by genetic variants associated with disorders of neurodevelopment. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Ebrahim | Azizi | Medical School | Int Med Nephrology | Our research is focused on profiling RNA expression in cancer stem cells (CSCs) and circulating tumor cells (CTCs) using Single Cell RNASeq and targeted gene expression. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Ryan | Bailey | LSA | Chemistry | The Bailey group develops and deploys multiplexed analytical tools to quantitate miRNA, mRNA, and lncRNA signatures of health and disease. They also are interested in probing mechanisms of epigenetic regulation of gene expression. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| James | Bardwell | LSA | MCDB | Our lab focusses on chaperone biology, we are currently investigating our surprising finding that RNA may play a significant role in protein folding in vivo.Nucleic Acids Research. 2016 Jun 2;44(10):4835-45 Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Sami | Barmada | Medical School | Neurology | RNA decay is critical for the maintenance of neuronal health and function. Our laboratory identified fundamental RNA decay abnormalities in the neurodegenerative diseases ALS and FTD, and is now focused on determining the etiology and consequences of these changes for neuronal survival and disease progression. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Scott | Barolo | Medical School | Cell & Dev Biology | Transcriptional regulation of gene expression; cis-regulatory elements (enhancers) Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Stuart | Batterman | Public Health | Environmental Health Sciences | Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Markus | Bitzer | Medical School | Int Med Nephrology | My research is focus on understanding the functions of non-coding RNA in kidney disease and aging. We have established an active biobank of currently over 100 human kidney tissue samples, which we are using to integrate transcriptomic profiles generated by microarray and RNA-sequencing, with quantitative morphometric (morphomic) data. Findings are validated in tissue culture and animal models of kidney injury and aging using genetic model systems as well as RNA-inhibitors and mimics. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Alan | Boyle | Medical School | Comp Med and Bioinformatics | We use modern genomics techniques and high-throughput experiments to explore biological systems. We can leverage computational tools to help answer biological problems that were previously intractable. We aim to combine computational approaches with high-throughput biological assays to better understand the whole human transcriptional regulatory system. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Charles | Brooks | LSA | Chemistry | Our group studies RNA structure, dynamics and folding using both all atom and coarse grained models. Current interests involve the assembly of the ribosome and it’s functional dynamics, the folding of complex RNA junction topologies, pH effects in RNA catalysis and protein-RNA/DNA interactions in translation and transcription. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Margit | Burmeister | Medical School | Molecular & Behav Neurosci Inst | In identifying genetic variants associated with Mendelian (e.g. Ataxia) and complex (e.g depression and addiction), often the variant in question is not protein coding. We have found, for example in 2010, that a 5'UTR variant increased mRNA expression 2-3 fold, resulting in deafness. We have published on miRNA expression differences possibly related to Bipolar disorder, and are involved in several projects, both related to ataxia and to addiction, in which we suspect that mRNA regulation plays a role. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Mark | Burns | Engineering | Chemical Engineering | Currently, I have some work in sensing RNA-containing pathogens (e.g., influenza), and I am considering expanding my work in this area. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Laura | Buttitta | LSA | MCDB | In the Buttitta Lab we are studying how gene expression at the mRNA level changes when cells enter quiescent or non-dividing states. We are also interested in the transcription factors and chromatin remodelers that may be influenced by cell cycle regulators to mediate changes in mRNA when cells enter quiescence. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Dawen | Cai | Medical School | Cell & Dev Biology | Single cell RNA profiling to identify neuronal stem/mature cell types and markers. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Sally Ann | Camper | Medical School | Human Genetics | interested in single cell RNA sequencing for understanding cell differentiation in health and disease Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Maria | Castro | Medical School | Neurosurgery | Glioma genetic models are needed to uncover mechanisms which mediate tumor progression, interplay with the tumor microenvironment (TME) and response to therapeutics. We have generated the first genetically engineered immunocompetent mouse model of low grade glioma(LGG), harboring mIDH1 in combination with ATRX and p53 knock-down. We have generated primary neurospheres (NS) from LGG, which exhibit cancer stem-cell- like properties, and have enabled us to develop a transplantable model of LGG, amenable to testing novel therapies. NS are derived from C57BL/6 mice, thus, enabling examination of the immune TME and the impact of tumor mutations on the immune response. Our goals are to assess the effect of mIDH1 on mRNA-seq, and on global DNA and histone methylation. The mIDH1 model will also be used for chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) to identify promoter/enhancer region specific changes in histone methylation. We are collaborating with Dr. Mats Ljungman who pioneered bromouridine sequencing (BrU-seq), to identify and quantify nascent mRNA and gene transcription profiles. Uncovering epigenetic patterning of histone 3 hypermethylation and cytosine modifications using next generation sequencing (NGS) technologies will contribute to the identification of novel pathways and gene regulatory networks which will provide novel insights into disease biology and uncover novel therapeutic targets. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Matt | Chapman | LSA | MCDB | The Chapman lab is interested in the production, turnover and processing of RNA during bacterial biofilm formation. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Grace | Chen | Medical School | Int Med | I am interested in how certain circulating non-coding small RNAs regulate colorectal cancer progression. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Vivian | Cheung | Medical School | Human Genetics | We study regulation of transcription; in particular, RNA-DNA sequence differences, RNA polymerase pausing and R-loop. We are interested in the mechanisms that underlie these processes, and how disruptions of these steps contribute to human neurologic disorders. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Arul | Chinnaiyan | Medical School | Pathology | Dr. Chinnaiyan's research is focused on functional genomic, proteomic and bioinformatics approaches to study cancer for the purposes of understanding cancer biology as well as to discover clinical biomarkers. His group has characterized a number of biomarkers of prostate cancer including AMACR, EZH2, hepsin and sarcosine. AMACR is being used clinically across the country in the assessment of cancer in prostate needle biopsies. The landmark study from Dr. Chinnaiyan's lab thus far is the discovery of TMPRSS2-ETS gene fusions in prostate cancer. TMPRSS2-ETS gene fusions are specific markers of prostate cancer as well as presumably function as rational targets for this disease. This finding potentially redefines the molecular basis of prostate cancer as well as other common epithelial cancers. Currently efforts are underway to target this gene fusion as well as discover similar gene fusions in other common epithelial tumors such as those derived from the breast, lung, and colon. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Michael | Cianfrocco | Medical School | Biological Chemistry | Motor protein dependent RNA localization & structural biology using cryo-electron microscopy Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Justin | Colacino | Public Health | Environmental Health Sciences | Our goal is to characterize the environmental susceptibility of normal human stem cell populations, elucidating the etiology of sporadic cancers. Of particular interest are understanding the changes that occur at the epigenomic and transcriptomic level, changes which affect not only gene expression but also how progenitor cells differentiate and divide. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Catherine | Collins | LSA | MCDB | My lab is interested in mechanisms that regulate structural plasticity of axons. A major focus is the study of an axonal damage sensing pathway - we want to understand the cellular mechanisms by which a neuron 'knows' that its axon is damaged, and how neurons are able to reform lost connections after damage. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Kathleen | Collins | Medical School | Int Med Nephrology | We study the ability of HIV to establish a persistent infection in long lived cells. We are interested in novel approaches to detect and eradicate these cells. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Analisa | DiFeo | Medical School | Pathology | My laboratory investigates epithelial ovarian cancer (EOC) biology at the interface between the bench and the clinic in order to generate findings that can directly benefit ovarian cancer patients. In order to accomplish this we focus on four major areas: 1) generation of clinically relevant EOC models, 2) development of novel or re-purposed drugs that can work alone or in conjunction with current treatment options to combat this deadly disease, 3) discovery of potent drivers of drug resistance and recurrence, and 4) identify novel biomarkers for early detection or therapeutic response. We have uncovered that microRNA-181a is frequently overexpressed in recurrent, platinum-resistant HGSOC tumors and correlates with shorter time to recurrence and poor overall survival. Functionally, we found that it can modulate several potent cancer-associated pathways such as TGF-β and Wnt signaling which in turn leads to the induction of epithelial-to-mesenchymal transition (EMT), drug resistance and increase tumor-initiating capacity. Most recently, we have developed a unique method to isolate primary tumor cells based miRNA function and identify drugs that regulate its expression using miRNA biosensors. Through these studies we uncovered that the miR-181a promoter contains a super enhancer which is targeted by Bromodomain inhibitors (BETi). Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Yali | Dou | Medical School | Pathology | Our broad objectives are to study how chromatin modifying enzymes contribute to essential cellular processes such as transcription regulation and how their activities are regulated on chromatin. Our current focuses are on the MLL/SET1 family histone H3 lysine 4 methyltransferases and MYST family histone acetyltransferase MOF. These enzymes play important roles in shaping the epigenetic landscape and higher order chromatin structures in higher eukaryotes. Our studies highlight importance of epigenetic regulation in cell fate commitment and plasticity in embryonic stem cells and leukemia stem cells. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Gregory | Dressler | Medical School | Pathology | The Dressler lab studies genes and pathways that regulate not only embryonic development and but also contribute to adult disease. Aspect currently being investigated by genetic and biochemical means are the structure and functions of long 5' untranslated regions of specific mRNAs and how these complex regions impact translation and gene expression of key regulatory proteins. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Monica | Dus | LSA | MCDB | The Dus lab is interesting in understanding how the environment reshapes brain and behavior. To this end we are studying how diet changes the physiology of the brain by altering metabolic-epigenetic pathways at both the transcriptional and post-transcriptional levels, and how this, in turn, affects behavior. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Eric | Fearon | Medical School | Int Med Nephrology | The Fearon laboratory's interests include the role of non-coding RNAs regulated by key oncogene and tumor suppressor gene pathways in colorectal cancer development and in invasive and metastatic phenotypes. In addition, the Fearon laboratory is utilizing CRISPR-Cas9 approaches to generate novel genetically engineered mouse models of colorectal cancer as well as the role of collaborative somatic oncogene and tumor suppressor gene defects in tumor initiation and clonal evolution. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Eva | Feldman | Medical School | Neurology | Amyotrophic lateral sclerosis (ALS) is a progressive degeneration of motor neurons that develops from a complex interaction of genetic, epigenetic, and environmental factors. We are investigating the role of altered RNA and protein metabolism in ALS by focusing on mRNA stability, microRNA dysregulation, RNA exosomes, and microRNA/protein interactions in patient tissues and cellular models. Our study of RNA in ALS will help identify early diagnostic biomarkers and elucidate pathological mechanisms that could point to possible therapeutic targets. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Claudia | Figueroa-Romero | Medical School | Neurology | I am interested in the complex molecular mechanisms regulating gene expression. My research focuses on understanding the role of microRNAs as regulators of RNA decay as a pathological mechanism in neurodegeneration, especially ALS. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Aaron | Frank | LSA | Chemistry | In order to understand the relationship between molecular structure and dynamics and biological function, the Frank research group seeks to develop and deploy integrative modeling tools to elucidate the structure and dynamics of biologically relevant molecules. We are primarily interested in using our methods to understand how functional ribonucleic acids achieve specific cellular functions. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Peter | Freddolino | Medical School | Biological Chemistry | Measurement of protein-RNA and RNA-RNA interactions driving microbial regulatory networks. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| George | Garcia | Pharmacy | Medicinal Chemistry | In the past, we have studied post-transcriptional modification of tRNA. Currently we are pursuing RNA polymerase as a drug target for tuberculosis. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Amanda | Garner | Pharmacy | Medicinal Chemistry | The Garner Laboratory is developing novel high-throughput screening assays for the discovery of chemical probes for targeting microRNAs and microRNA-microRNA-binding protein interactions. In addition, we are engaged in the discovery of new microRNA-binding proteins using chemical biology and proteomic approaches. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Scott | Gitlin | Medical School | Int Med Nephrology | Retroviruses; viral gene expression. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Thomas | Glover | Medical School | Human Genetics | Our research focuses on the mechanisms and consequences of genome instability and on the molecular biology of human genetic disease. A longstanding interest is the study of chromosome damage following replication stress. This began with the study of chromosome fragile sites and has led to our current focus on copy number variants (CNVs).Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Daniel | Goldman | Medical School | Molecular & Behav Neurosc Inst | Molecular mechanisms underlying retina and optic nerve regeneration in fish and mammals. Regarding RNA, our research studies transcriptional and posttranscriptional mechanisms contributing to regeneration, including microRNAs and other non-coding RNAs. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Stephen | Goutman | Medical School | Neurology | Dr. Goutman completed his medical degree from the University of Chicago’s Pritzker School of Medicine, and completeded his neurology residency and a Fellowship in Neuromuscular Disease at the Cleveland Clinic Hospital in Cleveland, Ohio. His clinical and research interests focus on amyotrophic lateral sclerosis (ALS). Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Yuanfang | Guan | Medical School | Comp Med & Bioinformatics | Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Johann | Gudjonsson | Medical School | Dermatology | Gudjonsson’s lab focuses on analysis of coding and non-coding RNA transcription in cells and tissues, and addressing their role in normal and diseased state, with a particular focus on skin. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Erdogan | Gulari | Engineering | Chemical Engineering | Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Deborah | Gumucio | Medical School | Cell & Dev Biology | Work in the lab is focused on organogenesis of the gastrointestinal tract. We are attempting to learn how this simple tube that is generated in the embryo is regionally patterned to become esophagus, stomach, small intestine and large intestine. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Gary | Hammer | Medical School | Int Med Nephrology | Dr. Hammer's research focuses on the molecular underpinnings of adrenocortical growth in development and cancer. His laboratory's goals are to characterize the adrenocortical stem/ progenitor cell population and elucidate how altered regulation of these cells contributes to adrenocortical disease, namely hypoplasias, dysplasias and cancer. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Sue | Hammoud | Medical School | Human Genetics | Single Cell RNAseq Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Alfred | Hero | Engineering | COE EECS - ECE Division | The Hero lab works on translational research that develops algorithms and models for personalized precision medicine that combine data from very different platforms for predicting disease outcomes and contagiousness. Data that we are working with include synchronized genomic modalities such as HiC, RNAseq and ChipSeq, imaging data including FISH and fMRI, For more info: Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Gerry | Higgins | Medical School | Comp Med and Bioinformatics | My current research focuses on the regulation of gene expression and the pharmaco-epigenome (e.g. noncoding regulatory variants and elements). My published research has included studies of the mechanisms of alternative splicing of CNS genes. I also teach in the RNA-Seq course (BIoINF 545; BIOSTAT 646) Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Shigeki | Iwase | Medical School | Human Genetics | Our group studies histone methylation-mediated mechanisms underlying mRNA production, i.e. transcription, in the brain. Given that many histone methyl regulators are mutated in cognitive disorders, our research may yield important insights into how histone methylation is involved in normal and pathological brain development and function. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Ursula | Jakob | LSA | MCDB | Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Paul | Jenkins | Pharmacy | Medicinal Chemistry | The Jenkins is lab is interested in the splicing of neuronal genes and how dysregulation of this process underlies neuropsychiatric disorders. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Hui | Jiang | Public Health | Biostatistics | My research interest is in developing statistical and computational methods to analyze RNA-Seq data for the quantification of gene and isoform expression and the detection of differentially expressed or spliced genes. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Andrew | Johnston | Medical School | Dermatology | Dr. Johnston's primary research interest is the identification of immunological pathways involved in the pathogenesis of psoriasis. He is currently investigating how recently identified members of the IL-1, IL-17 and IL-36 families of cell signaling molecules contribute to the immune cell activation and infiltration that is characteristic and necessary for the development of psoriasis skin lesions. Additionally, Dr. Johnston is examining the role of the bacteria that colonize the tonsil and the skin (the microbiome) in the triggering and maintenance of psoriasis skin lesions. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Alon | Kahana | Medical School | Ophthalmology & Visual Science | The Kahana lab studies how cells “define” their identities, and specifically how cells reprogram their identities in response to injury, disease, or a signaling cue. We focus on skeletal muscles because multinucleated syncytial myocytes are the ultimate differentiated cell, and muscle disorders are so common and debilitating. We are using adult zebrafish to study the molecular mechanisms underlying reprogramming a “post-mitotic” differentiated myocyte into a proliferating myoblast. The reprogramming process involves very active chromatin remodeling, and both lncRNAs and miRNAs appear to have very significant roles in regulating epigenetic reprogramming - roles that may be similar in the biology of cancer stem cells. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Sundeep | Kalantry | Medical School | Human Genetics | Our research aims to define how epigenetic regulation occurs in mammals. We use X-chromosome inactivation, which results in transcriptional silencing of most genes along one of the two X-chromosomes in female mammals, to gain insights into epigenetic processes, including through chromatin modifications and long-non coding RNAs. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Hyun Min | Kang | Public Health | Biostatistics | Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Sarah | Keane | LSA | Biophysics | Structure and mechanism on noncoding RNAs. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Evan | Keller | Medical School | Urology | Explore single cell transcriptomes through single cell RNASeq. Primarily focused on cancer. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Tom | Kerppola | Medical School | Biological Chemistry | Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Jeffrey | Kidd | Medical School | Human Genetics | We study determinants of viral latency and reactivation as well as the contribution retrotransposons to disease, phenotypic diversity, and genome evolution. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Steven | King | Medical School | Int Med Nephrology | Visit Website | |
| Anthony | King | Medical School | Psychiatry | Gene expression in humans with PTSD. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Jacob | Kitzman | Medical School | Human Genetics | The Kitzman lab develops new experimental and computational approaches to dissect the functional impacts of genetic variants. We are applying these to several clinically-relevant genes and non-coding elements, with the goal of comprehensively measuring the effects of all possible variants at each locus, from their transcription and splicing to the activity of the resulting encoded RNAs and proteins. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Raoul | Kopelman | LSA | Chemistry | Use of siRNA for cancer therapy, Nanotherapeutics with siRNA. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Markos | Koutmos | LSA | Chemistry | RNA processing, RNA modifications. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Kristin | Koutmou | LSA | Chemistry | The Koutmou lab studies the essential molecular machine responsible for translating the nucleic acid code into protein, the ribosome. We use a combination of in vitro biochemistry (eg. reconstituted translation system) and genome wide tools (eg. ribosome profiling) to investigate the molecular level details of situations in which translation is dysfunctional. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Steven | Kregel | Medical School | Pathology | Biomarkers, cancer, methylation, RNA modifications, prostate, plasma serum urine detection, drug resistance, protection | |
| Matthias | Kretzler | Medical School | Int Med Nephrology | Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Chandan | Kumar-Sinha | Medical School | Pathology | Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Steve | Kunkel | Medical School | Pathology | Research directed at understanding the expression and regulation of inflammatory mediators and their subsequent biological activities represent major investigative directions of my laboratory. A general theme of the laboratory is an assessment of the mechanistic involvement of cytokine and chemokine cascades that direct the initiation and maintenance of the immune response. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Katsuo | Kurabayashi | Engineering | Mechanical Engineering | Integrated optofluidic microsystem technology for advanced droplet-based high-throughput profiling of single-cell transcriptomes. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Kenneth | Kwan | Medical School | Molecular & Behavioral Neurosi Inst | Trafficking and local translation in neurons. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Roland | Kwok | Medical School | OB/GYN | My research focuses on how protein post-translational modifications, specially acetylation and phosphorylation, alter protein function in cancer cells. Recently we have described a molecular mechanism by which histone deacetylase inhibitors, a new class of therapeutic agents for cancer treatment, induce cell death in neuroblastoma cells. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Adam | Lauring | Medical School | Int Med Nephrology | Adam Lauring’s laboratory studies the population genetics and evolutionary dynamics of RNA viruses, which replicate with extremely low fidelity. Core projects include understanding the molecular determinants of RNA virus mutation rates and the impact of mutations on viral fitness. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Jun | Li | Medical School | Human Genetics | My group has a long-standing interest in classification and unsupervised class discovery, especially for high-dimensional genomics data. I am co-directing the proposed Michigan Center for Single-Cell Genomic Data Analytics, focusing on single-cell RNAseq data and currently including studies of cancer evolution, organ development, gene-environment interaction, and regulation of RNA splicing. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Yongqing | Li | Medical School | Surgery | Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Jiandie | Lin | Medical School | Cell & Dev Biology | My group studies how long noncoding RNAs (lncRNAs) regulate metabolic gene programs in adipose tissues and the liver. We are interested in dissecting the role of lncRNAs in the control of energy metabolism in physiological and disease states. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Jie | Liu | Medical School | Comp Med and Bioinformatics | machine learning, chromatin organization, alternative splicing Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Mats | Ljungman | Medical School | Radiation Oncology | My lab is studying mechanisms of transcriptional and post-transcriptional regulation of gene expression in normal physiology and in diseases such as cancer and ALS. We have developed nascent RNA Bru-seq that we are happy to help other labs use. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Pedro | Lowenstein | Medical School | Neurosurgery | Glioma stem cells exist in two states: as stem cells proper, and as brain tumor cells. We are currently working to understand the molecular underpinnings of state change in glioma tumors stem cells. This involves many studies that use RNA-seq, Bru-seq (with Mats Ljungman), and Linc-seq. Studies on self-organization in brain tumors and mechanisms of tumor growth (both in rodents and in humans), and the response of glioma tumors to immune attack, also require for us to study the dynamics of RNA. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Andrew | Ludlow | Kinesiology | Kinesiology | Broadly, my laboratory studies telomere and telomerase biology. We are interested in the gene expression regulation of telomere maintaining genes, such as telomerase component hTERT. We focus on the gene expression regulation by alternative RNA splicing by studying deep intronic elements and the RNA binding proteins that bind these elements in diverse tissues and contexts such as in lung cancer and in cells/tissues following interventions (exercise, diet, and chemotherapy). Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights View Research Output | |
| Janine | Maddock | LSA | MCDB | Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Anna | Mapp | LSA | Chemistry | Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| David | Markovitz | Medical School | Int Med Infectious Diseases | The Markovitz laboratory studies the genetics of human centromeres, a last frontier in genomics. As part of this effort, the group investigates the RNA transcripts that arise from individual centromeres. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Richard | Mc Eachin | Medical School | Comp Med and Bioinformatics | As managing director of the UMMS BRCF Bioinformatics Core, I am responsible for analysis of a broad and dynamic range of RNA-related (expression, RNA-editing, integrative RNA/DNA or RNA/protein, etc) data types. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Miriam | Meisler | Medical School | Human Genetics | working on alternative splicing of sodium channel gene transcripts. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Gustavo | Mendonca | Dentistry | Biologic & Mat Science | Effect of nano-topography on mesenchymal stem cells and differentiation into osteoblasts and the molecular basis of dental implants osseointegration. Use of RNA-Seq for identification of expressed mRNAs and miRNAs during bone healing. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Daniela | Mendonca | Dentistry | Biologic & Mat Science | miRNA involved in cancer. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Rajasree | Menon | Medical School | Comp Med and Bioinformatics | Alternative splice isoforms; Single cell RNA. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Ryan | Mills | Medical School | Comp Med and Bioinformatics | Our laboratory develops methods for analyzing RNA sequence data, with a focus on quantifying and assessing rates of translation using ribosome footprinting techniques. We are also actively studying novel mechanisms of translational regulation at the transcriptional level. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Stephanie | Moon | Medical School | Human Genetics | Our group is interested in how genes are expressed via the coordinated regulation of messenger RNAs at the levels of translation, localization, and decay. We study mRNA regulation in the context of human disease and stress, with a particular interest in neurological disorders. Our research aims to reveal the underlying principles and mechanisms governing mRNA in both health and disease to elucidate new therapeutic and diagnostic strategies. | |
| John | Moran | Medical School | Human Genetics | The goal of our laboratory is to understand how an abundant class of "jumping genes," known as LINE-1 retrotransposons, impacts the structure and function of human genomes. We use molecular biological, biochemical, modern genomic, and computational approaches to address the following questions: 1) What is the molecular mechanism of LINE-1 retrotransposition? 2) How do LINE-1 retrotransposition events impact the human genome? 3) Which cellular factors promote or restrict LINE-1 retrotransposition? 4) How does LINE-1 retrotransposition contribute to intra- and inter-individual genetic variation? Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Deepak | Nagrath | Engineering | Biomedical Engineering | We are very interested in understanding functional effects of exosomal cargo in tumor microenvironment. In our recent work published in eLife, we uncovered the metabolic role of exosomes secreted by tumor microenvironment in cancer metabolism. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Sunitha | Nagrath | Engineering | Chemical Engineering | We are developing microfluidic devices for isolating and studying circulating tumor cells (CTCs) as related to metastasis, the cause of over 90% of cancer related deaths. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Jayakrishnan (JK) | Nandakumar | LSA | MCDB | We are interested in the biogenesis, trafficking, recruitment to telomeres, and catalytic mechanism of the RNP enzyme telomerase. We are also investigating other noncoding RNAs that are involved in gene regulation. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Nouri | Neamati | Pharmacy | Medicinal Chemistry | The major focus of our research is to combine chemoinformatics and bioinformatics technologies to better elucidate the mechanisms of action of novel anticancer drugs developed in our laboratory. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Melanie | Ohi | Medical School | Cell & Dev Biology | Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Gilbert | Omenn | Medical School | Human Genetics | My RNA-related research is focused on differential expression of splice transcripts and proteins in proteogenomic studies of cancers, including a special emphasis on ERBB2+ breast cancers. Splicing is a remarkable phenomenon of the evolution of multicellular organisms with multi-exonic genes, making standard reports of up-regulation and down-regulation of “genes” a crude summary of a mixture of functionally-differentiated products of individual genes. Specific isoforms may be better biomarker candidates and therapeutic targets. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Akira | Ono | Medical School | Microbiology and Immunology | We are interested in the roles and/or behaviors of viral RNAs and cellular RNAs during virus particle assembly of HIV-1 and influenza A virus. Specific topics we are currently studying are 1) tRNA-mediated regulation of HIV-1 Gag membrane binding, 2) effects of RNA-mediated Gag multimerization on Gag localization, and 3) delivery of viral RNA segments to the site of influenza virus assembly. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Edgar | Otto | Medical School | Int Med Nephrology | We apply high-throughput droplet-based single cell RNA-Seq microfluidic technology (Drop-Seq) to analyze kidney cells derived from healthy or diseased kidney samples. This project may help to identify new cell type specific biomarkers for diagnostics, disease progression, or for potential therapeutic interference. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Ximena | Paez-Colasante | Medical School | Neurology | The pathogenesis of amyotrophic lateral sclerosis (ALS) involves a complex interaction between genes, environmental exposure, and epigenetics. We are investigating the role of altered RNA and protein metabolism in ALS by focusing on mRNA stability, microRNA dysregulation, and miRNA/protein interactions in patient tissues and cellular models. We aim to elucidate pathological mechanisms and postulate miRNA diagnostic biomarkers and therapeutic targets. Visit Website | |
| Nallasivam "Nalla" | Palanisamy | Medical School | Pathology | The main focus of RNA related research in my laboratory is to discover and validate novel expressed pseudogene derived RNA transcripts in cancer. Develop multiplex RNA in situ hybridization methods for the in situ detection of protein coding genes with no specific antibody, non coding RNA and pseudogene transcript using FFPE tissue. The ultimate goal of my research work is to understand the expression pattern of novel cancer associated markers in relation to tumor heterogeneity. I am looking forward to work investigators who may need assistance in setting up RNA in situ hybridization assay. Visit Lab Website | |
| Bruce Allan | Palfey | Medical School | Biological Chemistry | Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Petros | Papagerakis | Dentistry | Orthodontics & Pediatric Dentistry | Changes of RNA expression levels in diseases and mechanisms of RNA regulation. | |
| Meeyoung | Park | Medical School | Neurology | Identification of RNA changes in neurodegenerative diseases such as ALS and diabetic neuropathy. Visit Website | |
| Stephen | Parker | Medical School | Comp Med and Bioinformatics | Integration of genome, epigenome, and transcriptome (mRNA, eRNA) data across tissues and species to identify mechanisms underlying T2D GWAS SNPs. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Daniel | Peltier | Medical School | Pediatric Hematology/Oncology | We are interested in long noncoding RNA regulation of alloimmunity after hematopoietic stem cell transplantation with a particular focus on the regulation of allogeneic T cells. | |
| Brian | Pierchala | Dentistry | Biologic & Mat Science | We are using a genetically-encoded Ribosome tagging system (Ribotag mouse) to isolate and sequence the translatomes that are specifically in the axons of motor neurons. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Sethu | Pitchiaya | Medical School | Pathology | Interested in investigating the potential of combining anti-lncRNA therapy with existing treatment options to identify effective combinatorial treatment strategies and to further understand the global impact of ARlnc1 in prostate cancer. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Ping | Qiu | Medical School | Int Med Nephrology | Long non-coding RNA , epitranscriptomics and RNA m6A modification in vascular smooth muscle differentiation and phenotypic modulation | |
| Kaushik | Ragunathan | Medical School | Biological Chemistry | My lab is interested in the molecular mechanisms that define how the combinatorial logic of histone modifications and its dynamic interactions with histone binding proteins encodes stable and heritable patterns of gene expression. We take a multidisciplinary perspective that synthesizes genetics, biochemistry and biophysical approaches to capture cellular processes across different spatial and temporal regimes. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Indika | Rajapakse | Medical School | Comp Med and Bioinformatics | The work in our lab is at the interface between mathematics and human genome biology. In particular, we study the dynamics of genome organization in human cells. From these data, our goal is to understand genome reprogrammability (=controllability) Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Diane | Robins | Medical School | Human Genetics | We study the role of androgen receptor in prostate cancer, using approaches such as RNA-seq in mouse and cell models to profile differential gene expression and alternative regulatory networks in disease progression and response to therapy. In a second project, we study the role of KRAB zinc finger proteins in epigenetic control of sex-specific gene expression, particularly as it impacts metabolism, in order to gain insight on the evolution of the recently expanded huge KRAB-ZFP gene family. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Brandon | Ruotolo | LSA | Chemistry | Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Russell | Ryan | Medical School | Pathology | I study distal enhancer regulation in cancer. I'm interested in learning more about the role of noncoding RNAs in enhancer function. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Maureen | Sartor | Medical School | Comp Med and Bioinformatics | My lab has developed methods for the interpretation of high-throughput gene expression (e.g. RNA-seq) data in terms of pathways and processes, and we are experts in interpreting the results of such experiments with complex designs. We also study RNA in relation to HPV-related head and neck squamous cell carcinomas, and HPV-host fusion transcripts. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Santiago | Schnell | Medical School | Molecular & Integrative Physiology | Develop mathematical and computational models to achieve a systems-level description of the mechanisms involved in RNA silencing. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Laura | Scott | Public Health | Biostatistics | Analysis of RNA-Seq on 300 muscle and adipose tissue samples from Finnish individuals. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Audrey | Seasholtz | Medical School | Molecular & Behav Neurosc Inst | Studies in the Seasholtz laboratory focus on the stress system and its links to anxiety, depression and addiction. We study the transcriptional and post-transcriptional regulation of the neuropeptide corticotropin-releasing hormone (CRH) and its receptors and binding protein in the brain and pituitary. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Jiaqi | Shi | Medical School | Pathology | Our lab is interested in studying how epigenetic alterations in pancreatic cancer affect transcription and how this effect contributes to pancreatic cancer development. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Lyle | Simmons | LSA | MCDB | We study the formation and resolution of RNA:DNA hybrids. We are interested in how the cell removes ribonucleotide misincorporation events and in understanding how persistent R-loops affect genome integrity. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Janet | Smith | Medical School | Biological Chemistry | We use structural biology to study RNA viruses, including the positive-sense RNA flaviviruses (dengue, Zika, West Nile) and the HIV-1 retrovirus. We have also investigated RNA-protein interactions in Rift Valley fever virus, a negative-sense bunyavirus. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Ryan | Spengler | Medical School | Int Med Nephrology | Extracellular RNA as biomoarkers | |
| Cristiane | Squarize | Dentistry | Periodontics & Oral Med | Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Jeanne | Stuckey | Medical School | Biological Chemistry | Jeanne Stuckey is a member of the crystallography core of the Center for HIV RNA Studies (CRNA). She is involved in the structure determination of RNA-protein complexes important in HIV replication. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Chitra | Subramanian | Medical School | Surgery | Interested in studying miRNAs and non coding RNAs that drive cancer stem cells and how treatment with Hsp90 chaperone inhibitors changes their effect. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Michael Mark Alexander | Sutton | Medical School | Molecular & Behav Neurosci Inst | The remarkable information processing capacity of neurons in the mammalian brain stems from the intricate organization of their synaptic connections and the ability of these synapses to change with experience. In brain areas such as the hippocampus, the ability of principal neurons to accommodate dense networks of synaptic connectivity is critical for higher cognitive functions such as learning and memory. Our group is interested in the molecular mechanisms that control the development, maintenance and plasticity of these synapses, and in particular, how the compartmentalization of these processes in dendrites can service the unique demands of different synaptic sites impinging on the same neuron. Our research uses a combination of electrophysiology, biochemistry, and molecular approaches in conjunction with high-resolution imaging in living neurons to study these questions. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Andrew | Tai | Medical School | Int Med Nephrology | The major interest of our laboratory is to identify and characterize cellular factors that support infection by RNA viruses, chiefly hepatitis C and dengue viruses. Defining these host factors may lead to targets for broadly acting antiviral agents with high genetic barriers for resistance. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Alice | Telesnitsky | Medical School | Microbiology and Immunology | The Telesnitsky lab is a virology lab that studies the genomic RNA of retroviruses. We collaborate with biophysicists to understand how alternate RNA structures define fates, and perform molecular genetics of retroviral RNA trafficking and replication roles. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Muneesh | Tewari | Medical School | Int Med Nephrology | The Tewari lab studies extracellular RNA, including microRNA, long noncoding RNA and other RNA classes that are released by cells upon cell turnover or via active release (eg extracellular vesicles). We are interested in new technologies for studying extracellular RNA (eg advanced next gen sequencing and computational approaches) and are investigating extracellular RNAs in blood as non-invasive biomarkers for cancer and other diseases. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Peter | Todd | Medical School | Neurology | Our lab studies how nucleotide repeat expansions lead to neurological disease with an aim of developing novel treatments based on mechanistic insights. Specifically, we study how repeats as RNA bind to proteins and prevent them from performing their normal functions. We also study how repeats support translation of toxic proteins in the absence of an AUG start codon through a process known as RAN translation. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Scott | Tomlins | Medical School | Pathology | Research in the Scott Tomlins lab utilizes integrative high-throughput approaches, including next generation sequencing, to molecularly profile genitourinary malignancies, including clinical subtyping of prostate cancer, as well as bladder and adrenocortical carcinoma. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Raymond | Trievel | Medical School | Biological Chemistry | Our laboratory studies the structures and functions of enzymes that regulate mRNA stability to govern gene expression and cellular metabolism. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Lam C. (Alex) | Tsoi | Medical School | Dermatology | Dr. Tsoi has strong interests in investigating the pathology and genetic architecture of complex cutaneous disorders using systems biology approaches. Working with Drs. James T. Elder and Johann E Gudjonsson, Dr. Tsoi’s research aims to develop analysis pipelines and computational approaches to provide biological inferences from genetics and genomics data. His work in genetic association studies revealed over 30 novel psoriasis susceptibility regions, and highlighted different disease pathways. He also led the analysis and developed computational pipeline to study psoriasis transcriptomes, and his work uncovered over 1,000 novel transcripts in skin. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| David | Turner | Medical School | Molecular & Behav Neurosci Inst | The Turner lab studies microRNAs, gene regulation, and cell identity during development of the mammalian nervous system. We use the mouse retina as a model system and apply sequencing methods (small RNA-seq, PAR-CLIP, RNA-seq, m6A-seq), as well as CRISPR/Cas9, RNAi, and other functional methods to study or modify gene expression in differentiating neurons. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Michael | Uhler | Medical School | Molecular & Behav Neurosci Inst | The Uhler laboratory studies the role of protein phosphorylation in the nervous system. Historically, the research has focused on the cAMP-dependent (PKA) and cGMP-dependent (PKG) protein kinases. These kinases phosphorylate a large number of neuronal substrates including receptors , ion channels and transcription factors to regulate the function of these proteins. During the characterization of transcriptional regulation by PKA and PKG, our laboratory developed the Surface Transfection and Expression Protocol (STEP) method for solid phase transfection and we have used it to identify novel regulatory sequences. More recently, we have collaborated with the Turner laboratory to develop lines of P19 embryonic carcinoma cells which undergo neuronal differentiation after induction of neurogenic bHLH proteins such as Ascl1. We are currently using these cell lines to characterize the role of PKA phosphorylation during neuronal differentiation. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Sarah | Veatch | LSA | Biophysics | Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| John | Voorhees | Medical School | Dermatology | Dr. Voorhees' research focuses on psoriasis and premature aging of the skin. The demonstration of psoriasis as a disease mediated by an overactive immune system, treatable by immunosuppressive drugs, has been his major accomplishment in the study of psoriasis. In sun-induced premature skin-aging and in natural aging, he and his colleagues have unraveled mechanisms whereby UV light and the passage of time destroy the skin’s collagen support. This understanding has provided insight into its treatment and prevention by pharmacologic agents. Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Nils | Walter | LSA | Chemistry | The Walter lab studies both non-coding and protein-coding RNAs, and how the former control the gene expression of the latter, using tools from biophysics, biochemistry, cell biology, molecular biology and chemical biology. Most prominently, we use leading-edge single molecule and super-resolution fluorescence microscopy and single molecule FRET approaches to probe the diverse functional mechanisms of transcriptional and translational riboswitches, the spliceosome, the RNA silencing and RNA interference machinery, ribozymes, as well as devices from DNA nanotechnology, in vitro and in live cells. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Lisha | Wang | Medical School | Pathology | To investigate mRNA/lnc RNA expression using RNA ISH technology | |
| Stanley | Watson | Medical School | Psychiatry | Visit Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Max | Wicha | Medical School | Int Med Nephrology | The Wicha lab has been a leader in the field of cancer stem cells(CSC’s) . They provides the initial description of CSC in a solid tumor are elucidating pathways which regulate these cells. This includes the study of Ln RNA’s as well as transcriptional regulators. They are also investigating epigenetic regulation of CSC and the role of chromatin structure in the regulation of the CSC transcriptome. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Andrzej | Wierzbicki | LSA | MCDB | We study how non-coding RNA regulates genome activity in eukaryotes using Arabidopsis thaliana as a model system. We are particularly interested in mechanisms used by long non-coding RNA to establish repressive chromatin modifications. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Thomas | Wilson | Medical School | Pathology | RNA-related research in the Wilson lab centers on two main areas: (1) the mechanisms by which replication-transcription conflicts impact DNA repair and genomic instability, especially copy number variants, and (2) participation with Dr. Ljungman in application of nascent RNA sequencing (Bru-seq). Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Patricia (Trisha) | Wittkopp | LSA | Ecology and Evolutionary Biology; Molecular, Cellular, and Developmental Biology | We study the genetic mechanisms controlling RNA production and how they vary within and between species. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Chao-Yie | Yang | Medical School | Int Med- Hematology/Onc | Splicing, Stress Granule, Drug Discovery. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Jianzhi (George) | Zhang | LSA | Ecology and Evolutionary Biology | RNA modification, RNA folding, translation Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Jifeng | Zhang | Medical School | UMH Internal Med-Cardiovascular | View Michigan Research Experts Profile View Altmetric Attention Highlights | |
| Yan | Zhang | Medical School | Biological Chemistry | Research interests include CRISPR, Cas9, NmeCas9, CRISPR-Cas3 system. Visit Lab Website | |
| Xiang | Zhou | Public Health | Biostatistics | We develop statistical methods and computational tools for analyzing array based or sequencing based RNA studies. Example application areas include differential expression analysis, removing batch effects, controlling for individual relatedness or population stratification, single cell RNA sequencing studies. Visit Lab Website View Michigan Research Experts Profile View Altmetric Attention Highlights |
