A cross-disciplinary team of scientists from the University of Michigan (U-M) has developed a biochemical technique that successfully measures the number of individual protein molecules present in blood at low concentrations. These findings are published in the Proceedings of the National Academy of Sciences (PNAS), September 2020. The scientists developed special antibody probes that…
By Elisabeth Paymal A team of scientists associated with the University of Michigan Center for RNA Biomedicine discovered unexpected cellular adaptation mechanisms in response to dehydration. The observed protein reaction has never been reported before. The research began while observing processing bodies (P-Bodies), which are membrane-less organelles (MLO) involved in RNA degradation in human cells….
Amanda Garner Associate Professor, Medicinal Chemistry, College of Pharmacy Member of our Executive Committee Lab Website Twitter: @ALGchembio The Garner Laboratory uses chemical biology, medicinal chemistry and molecular and cellular biology approaches to investigate the high-risk/high-reward areas of targeting microRNAs, RNA-protein and protein-protein interactions for probe and drug discovery. These efforts are part of…
Sara Aton, Ph.D. Associate Professor, Molecular, Cellular, and Developmental Biology College of LSA Lab Website Google Scholar profile ResearchGate profile Research interests The functions of sleep are a major unsolved mystery in modern biology. Increasing evidence suggests that sleep is by and for the brain, and our lab is focused on understanding what sleep…
ANN ARBOR, MI, AUGUST 19, 2020—”A pair” of scientists from the University of Michigan (U-M) Center for RNA Biomedicine receives the Chan Zuckerberg Initiative (CZI) Collaborative Pairs Pilot Project Awards. The U-M Center for RNA Biomedicine brought together two scientists for this highly competitive grant: principal investigator Stephanie Moon, Ph.D., Assistant Professor in Human Genetics,…
Sethu Pitchiaya, Ph.D. Assistant Professor, Department of Urology Assistant Professor, Department of Pathology Medical school Website: https://www.pathology.med.umich.edu/faculty/sethu Website: https://sethupitchiaya.org/ Twitter: @SethuPitchiaya Google scholar: https://scholar.google.com/citations?user=flPaAgUAAAAJ&hl=en I want to understand the fundamental principles governing RNA(-based) regulation and learn how this regulatory program goes awry in cancer. To do so, I take a spatially-resolved single-cell and single-molecule…
The Center for RNA Biomedicine is offering Grant Sprints. For more information, please contact Maria Stieve. Photo: Grant Sprint at the U-M Center for RNA Biomedicine, October 2019, clockwise from left to right, Elizabeth Tidwell, Markos Koutmos, Aaron Frank, Brandon Ruotolo, Varun Gadkari. Curiosity and passion lead scientists to their field of research, but a…
The U-M Center for RNA Biomedicine is looking for U-M Graduate Students and Postdocs to join its RNA Student & Postdoc Council for the 2022-23 academic year. The objective of the council is to work collaboratively across disciplines, build a scientific community, and generate ideas and activities that advance RNA research and education across the…
Joshi J. Alumkal, M.D. Professor, Associate Division Chief for Basic Research, Hematology-Oncology Division; Section Head, Genitourinary Medical Oncology Section, Internal Medicine, Medical School Visit Lab Website View Michigan Research Experts Profile Follow on Twitter: @AlumkalJoshi Our lab is focused on transcriptional regulation and how that contributes to lethal prostate cancer progression. We use biochemical, genomic,…
Alan Boyle Assistant Professor Computational Medicine and Bioinformatics Human Genetics Lab Website Twitter: @AP_Boyle Michigan Experts What are your research interests? My research group uses computational and wet lab techniques to study how genes are controlled in human cells. We have a large focus on how human variation can change this control and how…
Analisa DiFeo, Ph.D. Associate Professor Pathology and Ob/Gyn Michigan Medicine Twitter Faculty page DiFeo Lab LinkedIn Google Scholar Research Interests: Using a combination of in vitro and in vivo approaches, my lab hopes to better understand the mechanism by which both microRNA’s and the genes they regulate are involved in ovarian tumor biology at…
RNA is a leading-edge field of biomedical research that is quickly expanding at many public research and academic institutions in the US and Canada. The complexity of this research requires collaborations between scientists across disciplines and specialties, establishing communities of RNA scientists within each of these institutions. When the COVID pandemic required to postpone all…
Daniel Peltier M.D., Ph.D. Clinical Lecturer Pediatric Hematology/Oncology Video profile My scientific and clinical interests include discovering ways to modulate the immune system to help ameliorate childhood disease, especially high-risk pediatric malignancies. Currently, I am working with Dr. Reddy investigating novel ways RNA molecules impact T cell biology and alloimmunity. One aspect of this work…
by Elisabeth Paymal One of the hallmarks of ovarian cancer is genomic instability resulting in gain and loss of DNA throughout the entire genome, including many microRNAs (miRNA). Dr. DiFeo, Ph.D., Associate Professor of Pathology and of Obstetrics and Gynecology at Michigan Medicine, and her team, research which miRNAs are involved in the early stages…
Keane is U-M’s 15th scientist to receive this very prestigious award since its inauguration in 1985, and the first one since 2013. “For my lab what this award means is that we can take real chances and pursue these challenging projects that are really difficult in terms of methodology development and other technical challenges that…
Sarah Keane, Ph.D. Assistant Professor of Biophysics, William R. Roush Assistant Professor of Chemistry Biophysics and Department of Chemistry College of LSA https://sites.lsa.umich.edu/keane-lab/ @KeaneLab The Keane’s lab is interested in understanding how RNA molecules fold and how their three-dimensional structures impact function. RNAs play a number of different regulatory roles in health and disease…
May 27 2:00–4:00 pm, Concurrent Session 2, RNA Structure and Regulation Adrien Chauvier, Pujan Ajmera, Nils Walter, Competition between ligand binding and transcription factor NusA modulates riboswitch-mediated regulation of transcription 8:00–9:00 pm, Poster Session 2, Interconnected Processes Catherine Scull, The N-terminal region of the A12.2 subunit stimulates RNA polymerase I transcription elongation 9:00–10:00 pm, Poster Session 5, RNA…
The RNA Collaborative seminar series goal is to cross promote RNA research and strengthen and connect the RNA scientific community. More information is available on the RNA Collaborative Seminar Series webpage, supported by The RNA Society. We encourage RNA Centers across the world to join us. If your RNA Center is interested in joining this…
Launched in April 2020, the goal of the RNA Collaborative seminar series is to cross-promote RNA research to strengthen and connect the RNA scientific community. Proposed by the University of Michigan (U-M) Center for RNA Biomedicine, this initiative received great enthusiasm from seven RNA research centers. The group was quickly joined by two more centers…
The election of professors Janet L. Smith and Arul Chinnaiyan, both members of the Center for RNA Biomedicine Strategic Advisory Board, to the National Academy of Sciences is an outstanding validation of the excellence of the RNA research at the University of Michigan. Members are elected to the National Academy of Sciences in recognition of…
