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Kaushik Ragunathan Assistant Professor Department of Biological Chemistry My lab is interested in the molecular mechanisms that define how the combinatorial logic of histone modifications and its dynamic interactions with histone binding proteins encodes stable and heritable patterns of gene expression. We take a multidisciplinary perspective that synthesizes genetics, biochemistry and biophysical approaches to capture…

Charles L. Brooks III Cyrus Levinthal Distinguished University Professor of Chemistry and Biophysics Warner-Lambert/Park-Davis Professor of Chemistry Professor of Biophysics, Director of Biophysics Our group studies RNA structure, dynamics and folding using both all atom and coarse grained models. Current interests involve the assembly of the ribosome and it’s functional dynamics, the folding of complex…

  We explore single cell transcriptomes through single cell RNASeq. Primarily focused on cancer. Visit Website What are your research interests? I am interested in the interaction between the cancer and the microenvironment. This includes exploring how both macromolecules and physical forces modulate cancer growth. In addition, our lab focuses on single cell analysis technologies…

Xiang Zhou, Ph.D. Associate Professor Departments of Biostatistics We develop statistical methods and computational tools for analyzing array based or sequencing based RNA studies. Example application areas include differential expression analysis, removing batch effects, controlling for individual relatedness or population stratification, single cell RNA sequencing studies. Visit Lab Website Follow on Twitter: @xzlab_org   What…

  Andrew Ludlow, Ph.D. Assistant Professor, Movement Science Director, Integrative Molecular Genetics Laboratory School of Kinesiology   Broadly, my laboratory studies telomere and telomerase biology. We are interested in the gene expression regulation of telomere maintaining genes, such as telomerase component hTERT. We focus on the gene expression regulation by alternative RNA splicing by studying…

Aaron Frank, Ph.D. Assistant Professor Departments of Biophysics and Chemistry In order to understand the relationship between molecular structure and dynamics and biological function, the Frank research group seeks to develop and deploy integrative modeling tools to elucidate the structure and dynamics of biologically relevant molecules. We are primarily interested in using our methods to…

  Eva L. Feldman, M.D., Ph.D., F.A.A.N. Russell N. DeJong Professor of Neurology Director, Program for Neurology Research & Discovery Director, ALS Center of Excellence Amyotrophic lateral sclerosis (ALS) is a progressive degeneration of motor neurons that develops from a complex interaction of genetic, epigenetic, and environmental factors. We are investigating the role of altered…

Ryan Mills, Ph.D. Associate Professor of Computational Medicine and Bioinformatics Associate Professor of Human Genetics Our laboratory develops methods for analyzing RNA sequence data, with a focus on quantifying and assessing rates of translation using ribosome footprinting techniques. We are also actively studying novel mechanisms of translational regulation at the transcriptional level. Visit Lab Website…

Jiaqi Shi, M.D., Ph.D. Assistant Professor, Gastrointestinal and Hepatobiliary Pathology, Surgical Pathology Department of Pathology Our lab is interested in studying how epigenetic alterations in pancreatic cancer affect transcription and how this effect contributes to pancreatic cancer development. Visit Website View Michigan Research Experts Profile Follow on Twitter: @jiaqishi    What are your research interests?…

Sundeep Kalantry, Ph.D Associate Professor Associate Chair for Research Department of Human Genetics Our research aims to define how epigenetic regulation occurs in mammals. We use X-chromosome inactivation, which results in transcriptional silencing of most genes along one of the two X-chromosomes in female mammals, to gain insights into epigenetic processes, including through chromatin modifications…

    Anthony Antonellis, Ph.D James V. Neel Collegiate Professor of Human Genetics Chair, Department of Human Genetics Professor of Neurology, Medical School Our group is broadly interested in how human genetic variation affects gene and genome function. One area of research is grounded in the observation that mutations in aminoacyl-tRNA synthetases cause myriad disease…

Peter Todd, M.D., Ph.D Bucky and Patti Harris Professor of Neurology Our lab studies how nucleotide repeat expansions lead to neurological disease with an aim of developing novel treatments based on mechanistic insights. Specifically, we study how repeats as RNA bind to proteins and prevent them from performing their normal functions. We also study how…