Enjoy this video which details KLIPP, a “split enzyme” system pioneered by Center for RNA Biomedicine co-director, Mats Ljungman, Ph.D. During the KLIPP process, two non-functional Cas9 enzymes fused to Fok1 enzymes are brought together by a pair of guide RNAs. These guide RNAs specifically target sequences near structural variant junctions unique to cancer cells….
The Center for RNA Biomedicine hosted Pfizer’s Greg DiGennaro this week, an expert in Chemical Manufacturing and Controls (CMC) and international pharmaceutical regulations, for an informative webinar. Greg discussed navigating regulatory hurdles and Good Manufacturing Practices (GMP) in biomedical research and development. Below, you can find a YouTube video of his presentation, as well as…
ANN ARBOR, Mich., Apr 23, 2024 – We are thrilled to announce that Yan Zhang, Ph.D., Assistant Professor of Biological Chemistry at the University of Michigan, has won a distinguished CAREER Award from the U.S. National Science Foundation (NSF). The U.S. National Science Foundation (NSF) Faculty Early Career Development (CAREER) Program offers awards in support of…
The latest issue of RNA Translated, the University of Michigan Center for RNA Biomedicine annual magazine and brief report, has been published and is available in print and to view online now! The 2024 issue focuses on our groundbreaking efforts to build a University of Michigan “M-RNA Therapeutics” initiative, led by Michelle Hastings, Ph.D.,…
University of Michigan Center for RNA Biomedicine Co-Director Dr. Mats Ljungman presented research on his KLIPP technique at the American Association for Cancer Research (AACR) Annual Meeting at the San Diego Convention Center in California. Dr. Ljungman’s talk, “KLIPP: Precision targeting of cancer with CRISPR,” was given on Tuesday, April 9, as part of the…
What a thrill it was to welcome our keynote speakers, including the 2023 Nobel Prize laureate for Physiology and Medicine Dr. Drew Weissman, and registrants to the U-M Ann Arbor campus on Friday, March 8, as well as those who joined us LIVE via Zoom. University of Michigan President Santa J. Ono, Ph.D., welcomed speakers and…
We are thrilled to announce that Mats Ljungman, Ph.D., Co-Director of the Center for RNA Biomedicine at the University of Michigan, has just been awarded a $3.7 million grant from the National Institutes of Health (NIH) for the purpose of continuing his groundbreaking work with precision-targeting KLIPP cancer therapy – the project’s highest funding by…
Center for RNA Biomedicine Co-Director Nils Walter, Ph.D. is excited about sharing some news about yet another fascinating role RNA plays in gene regulation – and it’s about time… literally. In a new review article, “Regulation of bacterial gene expression by non-coding RNA: It is all about time!” published January 10, 2024 in the journal…
Up Next: The 2023-2024 RNA Innovative Seminar Series has concluded. Seminars will resume in September 2024, check back for updates! 2023 Monday, September 11, 4:00 pm, Graham Erwin, Stanford University Monday, September 25, 4:00 pm, Jeffrey Barrick, UT at AustinMonday, October 9, 4:00 pm, Guizhi (Julian) Zhu, University of MichiganMonday, October 23, 4:00 pm, Susan Gottesman,…
The 8th Annual Center for RNA Biomedicine Symposium will be held on March 8, 2024. As in years past, we will have an opportunity for trainees to present their work in the form of a poster session midway through the day. In addition, and new this year, each presenter will have the option of participating…
Center for RNA Biomedicine Faculty and Executive Committee Member Stephen C.J. Parker, Ph.D., Associate Professor, Departments of Computational Medicine & Bioinformatics, Human Genetics, and Biostatistics, just released new findings from a recent study on type 2 diabetes regulatory networks co-led by teams from the University of Michigan and Vanderbilt University. Type 2 diabetes results from a dysfunction of…
Every year on Giving Tuesday, millions of people around the world join together to support causes and organizations that are making a difference. At the University of Michigan, impactful projects across all three campuses and Michigan Medicine are funded each year thanks to the generosity of the U-M community on the Tuesday after Thanksgiving. With a…
October 24, 2023, The White House: In a formal ceremony presided over by President Biden, Huda Akil, Ph.D., was honored with the National Medal of Science Award, the nation’s highest scientific honor. A Center for RNA Biomedicine Faculty Member, Dr. Akil’s research focuses on understanding the neurobiology of emotions, including pain, anxiety, depression and substance…
How do you prove, in a laboratory setting studying objects in size just one-thousandth of the diameter of a hair, that something is doing what it is designed to do? The Walter Lab at the University of Michigan is doing just that, through single-molecule fluorescence imaging and tracking, and recently for a tiny nano engine…
Research Update: Sunitha Nagrath and Muneesh Tewari. CRB Faculty Members Sunitha Nagrath, Ph.D., and Muneesh Tewari, Ph.D., M.D., are learning the potential that liquid biopsies hold as a potential non-invasive, diagnostic tool. Their research is cited in a new article recently published in Health Lab. Dr. Nagrath reveals that circulating biomarkers found in bodily fluids…
Rooted firmly in his lab suite tucked deep within the core of the Pentagon-esque Medical Sciences Research Building (MSRB) complex on the University of Michigan campus, John Prensner, M.D., Ph.D., is focused on bringing to light an area of genomic investigation involving a hive of “worker bees” called noncanonical ORFs (open reading frames), that play…
The Nobel Assembly at the Karolinska Institutet has today decided to award the 2023 Nobel Prize in Physiology or Medicine jointly to Katalin KarikĂł and Drew Weissman. 1 Read the full press release. Drew Weissman, M.D., Ph.D., will be featured as a keynote speaker at the Center for RNA Biomedicine’s 8th annual RNA Symposium in March, 2024 at the University of…
A University of Michigan researcher has been appointed a 2023-24 White House Fellow. Monica Dus, associate professor of molecular, cellular and developmental biology in LSA, was chosen through a highly competitive selection process for her efforts in communicating science to the public. Dus was placed with the Department of the Navy. “I am so honored…
The discovery of insulin has saved the lives of millions of people with diabetes worldwide, but little is known about the first step of insulin synthesis. Researchers at the University of Michigan have uncovered part of this mystery. Examining messenger RNAs involved in the production of insulin in fruit flies, they found that a chemical…
We are thrilled to announce that Dr. Michelle Hastings has joined us as a faculty member in the Department of Pharmacology, and Director of the M-RNA Therapeutics Initiative at The Center for RNA Biomedicine. Dr. Hastings will lead one of the largest teams of RNA scientists in the world, as Director of M-RNA Therapeutics within…
