By Elisabeth Paymal A team of scientists associated with the University of Michigan Center for RNA Biomedicine discovered unexpected cellular adaptation mechanisms in response to dehydration. The observed protein reaction has never been reported before. The research began while observing processing bodies (P-Bodies), which are membrane-less organelles (MLO) involved in RNA degradation in human cells….
by Elisabeth Paymal One of the hallmarks of ovarian cancer is genomic instability resulting in gain and loss of DNA throughout the entire genome, including many microRNAs (miRNA). Dr. DiFeo, Ph.D., Associate Professor of Pathology and of Obstetrics and Gynecology at Michigan Medicine, and her team, research which miRNAs are involved in the early stages…
By Adam Diehl, Alan Boyle, and Elisabeth Paymal, Center for RNA Biomedicine Until recently, little was known about how transposable elements contribute to gene regulation. These are little pieces of DNA that can replicate themselves and spread out in the genome. Although they make up nearly half of the human genome, these were often ignored…
The cell is a complex network of interacting components, or molecules, each of them with its own characteristics and all of them together functioning as a living system. Each of the molecular processes and interactions in the cell bears the risk of becoming dysfunctional, resulting in disease. Biomedical research into processes that power the cell…
Over half of our genomes are made of repeating elements within DNA. In rare cases, these repeats can become unstable and grow in size. These repeat “expansions” cause neurodegenerative diseases such as ALS and Dementia as well as learning disorders and autism in Fragile X syndrome. Research to date has focused on how these expanded…
Rate of elongation by RNA polymerase II is associated with specific gene features and epigenetic modifications. Artur Veloso, Killeen S. Kirkconnell, Brian Magnuson, Benjamin Biewen, Michelle T. Paulsen, Thomas E. Wilson, and Mats Ljungman, Genome Research, 2014, doi: 10.1101/gr.171405.113
