A call for direct sequencing of full-length RNAs to identify all modification

For most organisms, DNA sequences are available, but the complete RNA sequences are not. Here, we call for technologies to sequence full-length RNAs with all their modifications. Article co-authored by Dr. Vivian Cheung, member of our Center.
Publication: Alfonzo, J.D., Brown, J.A., Byers, P.H. et al. A call for direct sequencing of full-length RNAs to identify all modifications. Nat Genet (2021). https://doi.org/10.1038/s41588-021-00903-1

Similar Posts

John Prensner charts a new path toward global standardization for ribosome profiling (Ribo-Seq)
|

John Prensner charts a new path toward global standardization for ribosome profiling (Ribo-Seq)

Rooted firmly in his lab suite tucked deep within the core of the Pentagon-esque Medical Sciences Research Building (MSRB) complex on the University of Michigan campus, John Prensner, M.D., Ph.D., is focused on bringing to light an area of genomic investigation involving a hive of “worker bees” called noncanonical ORFs (open reading frames), that play…

First step first: understanding normal processes before tackling pathologies

Photo: Adrien Chauvier, Ph.D., in the Nils Walter’s lab (Credit: Laura Penabad-Peña)   Dr. Adrien Chauvier’s journey has taken him around the world, from the Amazon rainforest to Michigan snowy winters, and his passion for science has never left him. He is now a postdoctoral fellow in Nils Walter’s lab, in the Department of Chemistry…

Nobel Laureates highlight University of Michigan’s Inaugural RNA Symposium

Ann Arbor, Mich. – Five prominent scientists, including two Nobel Laureates, will share the stage on March 25, 2016, when the University of Michigan’s Center for RNA Biomedicine holds its Inaugural Symposium. The Symposium, titled “Can RNA Answer It All? From the Origin of Life to a Future of Personalized Medicine,” will feature 2006 Nobel…

Building a better scientific world with hands-on science

Sometimes it takes exploration outside our usual interests to find our true passion. This is what happened to Sydney Rosenblum, now a graduate student in Rackham Graduate School Program in Chemical Biology, in Professor Amanda Garner’s lab. In high school, Sydney felt that “science was not for her,” somewhat irrelevant or too abstract, until she…