A call for direct sequencing of full-length RNAs to identify all modification

For most organisms, DNA sequences are available, but the complete RNA sequences are not. Here, we call for technologies to sequence full-length RNAs with all their modifications. Article co-authored by Dr. Vivian Cheung, member of our Center.
Publication: Alfonzo, J.D., Brown, J.A., Byers, P.H. et al. A call for direct sequencing of full-length RNAs to identify all modifications. Nat Genet (2021). https://doi.org/10.1038/s41588-021-00903-1

Similar Posts

2017 Symposium

“RNA in Precision Medicine” Read the Live Blog Check out our Symposium Video Featuring talented keynote speakers from across the world as well as six “mini-talks” presentations from across the University.   The Center for RNA Biomedicine Symposium brings together national leaders of the scientific, medical and engineering communities working on recent advances of our…

A scientist who “shrunk” down to explore a cell

Karen Montoya is a fourth year Ph.D. candidate in Nils Walter’s lab (Department of Chemistry, College of LSA) where she is studying state-of-the-art single molecule spectroscopy and imaging. Montoya’s interests in biosciences were sparked in part by “Osmosis Jones,” an animated action comedy about one white blood cell’s race against the biological clock to hunt…

RNA Featured Researcher – Adrien Chauvier, Ph.D., Chemistry

  Adrien Chauvier, Ph.D. Postdoctoral Fellow Walter Lab Chemistry, LSA   Your research interests in less than 100 words I aim to understand how RNA modulates gene expression using riboswitches as a model system. Riboswitches are structural elements that regulate transcription or translation through structural conformational change triggered by the binding of a specific ligand….

2022-2023 Seminars

2022 Monday, September 12, 4:00 pm, Zhipeng Lu, USC – Link to Recording Monday, September 26, 4:00 pm, David Shechner, University of Washington  Monday, October 10, 4:00 pm, Polly Hsu, Michigan State University – Link to Recording Monday, October 17, 4:00 pm, John Cooke, Houston Methodist – Link to Recording Monday, November 21, 4:00 pm,…

|

Stressed cellular proteins break social distancing rules

By Elisabeth Paymal A team of scientists associated with the University of Michigan Center for RNA Biomedicine discovered unexpected cellular adaptation mechanisms in response to dehydration. The observed protein reaction has never been reported before. The research began while observing processing bodies (P-Bodies), which are membrane-less organelles (MLO) involved in RNA degradation in human cells….