"Long non-coding RNAs as evolutionarily fluid chromatin weavers" Selene L. Fernandez-Valverde, Ph.D. Principal Investigator Advanced Genomics Unit LANGEBIO, Cinvestav   Flyer in PDF HYBRID SEMINAR: In-person: BSRB, ABC seminar rooms Zoom: https://umich.zoom.us/webinar/register/WN_3ga-wcUYSgqPEKw57DSfpg Keywords: lncRNAs, Genomics, Genome topology Abstract: Long non-coding RNAs (lncRNAs) have recently emerged as prominent elements of the regulatory transactions of eukaryotic genomes....

"The Democratization of RNA Therapeutics" John Cooke, M.D., Ph.D. Joseph C. “Rusty” Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research, Department of Cardiovascular Sciences Chair, Department of Cardiovascular Sciences Professor of Cardiovascular Sciences, Academic Institute Full Member, Research Institute Director, Center for Cardiovascular Regeneration Medical Director, Center for RNA Therapeutics Houston...

"RNA:DNA hybrids cause genome instability through nucleobase deamination, genomic rearrangements, and induction of the DNA damage response" Jeremy Schroeder, Ph.D. Research Investigator Biological Chemistry University of Michigan     In-person: BSRB, ABC seminar rooms / hybrid link Abstract: The overall impacts of naturally occurring RNA:DNA hybrids on genome integrity, and the relative contributions of ribonucleases...

"Genetic, environmental, and developmental factors in immune cell gene expression and asthma" Francesca Luca, Ph.D. Professor Center for Molecular Medicine and Genetics Wayne State University     In-person: BSRB, ABC seminar rooms / hybrid link Abstract: Asthma is an immunological disorder with genetic and environmental components. In the last ten years we have been studying genetic...

"The Science Behind mRNA Medicines: COVID-19 Vaccines and Beyond" Melissa J. Moore, Ph.D. Chief Scientific Officer, Moderna Therapeutics, Emerita In-person: BSRB, Kahn Auditorium and hybrid. Here is the link for the seminar video. Dr. Moore will be awarded an honorary degree at the University of Michigan Ann Arbor campus’ 2022 Winter Commencement and give this...

"Antisense Oligonucleotides for Ataxia" Hayley McLoughlin, Ph.D. Assistant Professor of Neurology Assistant Professor of Human Genetics University of Michigan     In-person: BSRB, ABC seminar rooms / hybrid link Abstract: Her talk will cover recent advances in antisense oligonucleotide (ASO) therapy with a particular emphasis towards their mechanistic and therapeutic applications in Ataxia. She will...

"Genetic Variant Effects on Adipose Gene Expression and Their Role in Cardiometabolic Traits." Karen Mohlke, Ph.D. Professor and Associate Chair for Research Oliver Smithies Investigator Department of Genetics, University of North Carolina In-person: BSRB, ABC seminar rooms / hybrid link Abstract: Noncoding genetic variants can affect common diseases and related quantitative traits. Variants may affect...