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RNA Innovation Seminar: Zhipeng Lu, USC
Monday, September 12, 2022 @ 4:00 pm - 5:00 pm
“RNA Structures, Interactions and Modifications”
Zhipeng Lu (鲁志鹏), Ph.D.
Pharmacology and Pharmaceutical Sciences
University of Southern California
In-person: BSRB, ABC seminar rooms / hybrid link
Abstract: RNA in living cells are in constant motion, form dynamic structures, and interact with many molecules, including other RNAs. Direct determination of RNA structures and interactions in vivo is essential to understanding their functions, but has been challenging in the past. We developed a number of novel chemical and computational tools to capture the 2D and 3D RNA structurome and interactome in cells, providing a comprehensive view of RNA conformations that underlie their roles in gene regulation and human diseases. Applications of these methods revealed new mechanisms in lncRNA functions, RNA modifications and splicing regulation.