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RNA Innovation Seminar: Paul Magwene, Ph.D., Duke University

"Signaling Pathway Variation and Evolutionary Hotspots in the Fungi" Paul Magwene, Ph.D. Professor of Biology Director, Computational Biology & Bioinformatics (CBB) Duke University   PDF Flier Hybrid Seminar In-person: BSRB, ABC Seminar Rooms Zoom: https://umich.zoom.us/webinar/register/WN_7wk1SlRdQ_e04VnwcjVV7g Keywords: population genomics, statistical genetics, gene networks, microbial pathogenesis Abstract: Evolutionarily conserved signal transduction pathways, such as Ras-cAMP-PKA, calcineurin, and...

RNA Innovation Seminar: Sika Zheng, UC Riverside, School of Medicine

"Unexpected determinants of neuronal identity and properties: the curious cases of PTBP1, PTBP2, and neuronal splicing" Sika Zheng, Ph.D. Associate Professor, Director of Center for RNA Biology and Medicine UC Riverside, School of Medicine   Flyer in PDF   Virtual Seminar Zoom: https://umich.zoom.us/webinar/register/WN_dltbxWdHQ5KrC3rTl4hqLQ Abstract: Alternative splicing is the major contributor to transcriptome diversity, but splicing...

RNA Innovation Seminar: Daniel O’Reilly

“An Academic Approach to Oligonucleotide Therapeutics” Daniel O’Reilly Ph.D., MRSC Post-Doctoral Associate Khvorova Lab RNA Therapeutics Institute University of Massachusetts Medical School Flyer in PDF   HYBRID SEMINAR: In-person: BSRC, ABC seminar rooms Zoom: https://umich.zoom.us/webinar/register/WN_dM1a1aKVTM2KfwiieutOWg Keywords: Oligonucleotides, Chemical Modifications, RNA, Huntington’s Disease Abstract: Nucleic acids (NA) are becoming the third major pillar of therapeutic modalities...

RNA Innovation Seminar: Analisa DiFeo & Bambarendage (Pini) Perera

HYBRID SEMINAR: In-person: BSRC, ABC seminar rooms Livestream: https://umich.zoom.us/webinar/register/WN_mXMOsCvlQrSyuJQO0_EnWw "A miRNA-mediated approach to dissect the complexity of cancer progression and identify anti-cancer drugs" Analisa DiFeo, Ph.D. Associate Professor Pathology and Ob/Gyn Michigan Medicine Abstract: High grade serous carcinoma (HGSC) the most common type of “ovarian” cancer is one of the deadliest cancers diagnosed in women....

RNA Innovation Seminar: Selene L. Fernandez-Valverde, Ph.D.

"Long non-coding RNAs as evolutionarily fluid chromatin weavers" Selene L. Fernandez-Valverde, Ph.D. Principal Investigator Advanced Genomics Unit LANGEBIO, Cinvestav   Flyer in PDF HYBRID SEMINAR: In-person: BSRB, ABC seminar rooms Zoom: https://umich.zoom.us/webinar/register/WN_3ga-wcUYSgqPEKw57DSfpg Keywords: lncRNAs, Genomics, Genome topology Abstract: Long non-coding RNAs (lncRNAs) have recently emerged as prominent elements of the regulatory transactions of eukaryotic genomes....

RNA Innovation Seminar: Zhipeng Lu, USC

"RNA Structures, Interactions and Modifications" Zhipeng Lu (鲁志鹏), Ph.D. Assistant Professor Pharmacology and Pharmaceutical Sciences University of Southern California   Flyer in PDF In-person: BSRB, ABC seminar rooms / hybrid link Abstract: RNA in living cells are in constant motion, form dynamic structures, and interact with many molecules, including other RNAs. Direct determination of RNA...

RNA Innovation Seminar: David Shechner, University of Washington

"Meet the neighbors: A universal technology for probing RNA-interactions and RNA-scaffolded subcellular compartments in situ" David Shechner Ph.D. Assistant Professor of Pharmacology University of Washington   Flyer in PDF In-person: BSRB, ABC seminar rooms / hybrid link Keywords: RNA, proximity-biotinylation, subcellular architecture, nuclear architecture, spatial biology, biomolecular condensates, interactomics, nucleolus, Xist.   Abstract: In the context...

RNA Innovation Seminar: Polly Hsu, Michigan State University

"Roadblocks on mRNAs? Gene Expression Regulation by Upstream Open Reading Frames in Plants" Polly Hsu, Ph.D. Assistant Professor Biochemistry and Molecular Biology Michigan State University     Flyer in PDF In-person: BSRB, ABC seminar rooms / hybrid link Keywords: translation, uORFs, nonsense-mediated decay Abstract: 30-70% of mRNAs in humans, mice and plants contain short ORFs,...

RNA Therapeutics Seminar: John Cooke, M.D., Ph.D., Medical Director, Center for RNA Therapeutics, Houston Methodist

"The Democratization of RNA Therapeutics" John Cooke, M.D., Ph.D. Joseph C. “Rusty” Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research, Department of Cardiovascular Sciences Chair, Department of Cardiovascular Sciences Professor of Cardiovascular Sciences, Academic Institute Full Member, Research Institute Director, Center for Cardiovascular Regeneration Medical Director, Center for RNA Therapeutics Houston...

RNA Innovation Seminar: Jeremy Schroeder, Biological Chemistry

"RNA:DNA hybrids cause genome instability through nucleobase deamination, genomic rearrangements, and induction of the DNA damage response" Jeremy Schroeder, Ph.D. Research Investigator Biological Chemistry University of Michigan     In-person: BSRB, ABC seminar rooms / hybrid link Abstract: The overall impacts of naturally occurring RNA:DNA hybrids on genome integrity, and the relative contributions of ribonucleases...