A call for direct sequencing of full-length RNAs to identify all modification

Rooted firmly in his lab suite tucked deep within the core of the Pentagon-esque Medical Sciences Research Building (MSRB) complex on the University of Michigan campus, John Prensner, M.D., Ph.D., is focused on bringing to light an area of genomic investigation involving a hive of “worker bees” called noncanonical ORFs (open reading frames), that play…
June 30, 2016: Palmer Commons, Fourth Floor Forum Hall – Edgar Otto : “Microfluidic droplet generation technology (Drop-Seq) enables high-throughput single cell transcriptomics” and Peter Freddolino : “The logic of transcriptional regulation in bacteria: From molecules to cells” June 23, 2016: Palmer Commons, Fourth Floor Forum Hall – John Moran : “Studies of a Human Retrotransposon” and Eric Fearon: “Working toward improved mouse models of somatic tissue mosaicism and cancer development” June…
RNA Translated’s main focus is on “2020, the year of the RNA viruses,” with representative contributions from 10 RNA faculty members. We also feature our two Research Cores and broadly report on the Center’s activity with a few highlights. With this publication, we aim to showcase the outstanding achievements and deep impact of the scientific collaborations…
BY PAUL AVEDISIAN and MICHELE SANTILLAN A team of U-M researchers has been awarded a $500,000 grant by the Cystic Fibrosis Foundation (CFF). Alexandra Piotrowski-Daspit, Ph.D., the PI, is a faculty member at the Center for RNA Biomedicine, and Assistant Professor of Biomedical Engineering and Internal Medicine – Pulmonary and Critical Care Medicine Division. Lindsay…
by Elisabeth Paymal In an article published in the journal RNA [1] , Karan Bedi, a bioinformatician in Mats Ljungman’s lab, Department of Radiation Oncology at the University of Michigan Medical School, investigated the efficiency of splicing across different human cell types. The results were surprising in that the splicing process appears to be quite…
Once again, the Nobel Prize recognizes the most revolutionary and innovative scientific discoveries that have the highest potential to transform humankind. Drs. Jennifer Doudna and Emmanuelle Charpentier, both biochemists, were awarded the Nobel Prize in Chemistry 2020 “for the development of a method for genome editing,” known as CRISPR. This RNA-guided tool allows to change…