"Roadblocks on mRNAs? Gene Expression Regulation by Upstream Open Reading Frames in Plants" Polly Hsu, Ph.D. Assistant Professor Biochemistry and Molecular Biology Michigan State University Flyer in PDF In-person: BSRB, ABC seminar rooms / hybrid link Keywords: translation, uORFs, nonsense-mediated decay Abstract: 30-70% of mRNAs in humans, mice and plants contain short ORFs,...
"The Democratization of RNA Therapeutics" John Cooke, M.D., Ph.D. Joseph C. “Rusty” Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research, Department of Cardiovascular Sciences Chair, Department of Cardiovascular Sciences Professor of Cardiovascular Sciences, Academic Institute Full Member, Research Institute Director, Center for Cardiovascular Regeneration Medical Director, Center for RNA Therapeutics Houston...
"RNA:DNA hybrids cause genome instability through nucleobase deamination, genomic rearrangements, and induction of the DNA damage response" Jeremy Schroeder, Ph.D. Research Investigator Biological Chemistry University of Michigan In-person: BSRB, ABC seminar rooms / hybrid link Abstract: The overall impacts of naturally occurring RNA:DNA hybrids on genome integrity, and the relative contributions of ribonucleases...
"Genetic, environmental, and developmental factors in immune cell gene expression and asthma" Francesca Luca, Ph.D. Professor Center for Molecular Medicine and Genetics Wayne State University In-person: BSRB, ABC seminar rooms / hybrid link Abstract: Asthma is an immunological disorder with genetic and environmental components. In the last ten years we have been studying genetic...
"The Science Behind mRNA Medicines: COVID-19 Vaccines and Beyond" Melissa J. Moore, Ph.D. Chief Scientific Officer, Moderna Therapeutics, Emerita In-person: BSRB, Kahn Auditorium and hybrid. Here is the link for the seminar video. Dr. Moore will be awarded an honorary degree at the University of Michigan Ann Arbor campus’ 2022 Winter Commencement and give this...
"Antisense Oligonucleotides for Ataxia" Hayley McLoughlin, Ph.D. Assistant Professor of Neurology Assistant Professor of Human Genetics University of Michigan In-person: BSRB, ABC seminar rooms / hybrid link Abstract: Her talk will cover recent advances in antisense oligonucleotide (ASO) therapy with a particular emphasis towards their mechanistic and therapeutic applications in Ataxia. She will...
"Genetic Variant Effects on Adipose Gene Expression and Their Role in Cardiometabolic Traits." Karen Mohlke, Ph.D. Professor and Associate Chair for Research Oliver Smithies Investigator Department of Genetics, University of North Carolina In-person: BSRB, ABC seminar rooms / hybrid link Abstract: Noncoding genetic variants can affect common diseases and related quantitative traits. Variants may affect...
"Role of Circular RNA in Alzheimer's Disease" Carlos Cruchaga, Ph.D. Director, NeuroGenomics and Informatics Center Washington University in St Louis In-person: BSRB, ABC seminar rooms / hybrid link Short Bio: Dr. Cruchaga is a human genomicist with expertise in multiomics, informatics, and neurodegeneration. He completed his PhD in Biochemistry & Molecular Biology in 2005 at...
"Why Did the RNA Cross the Nanotube? Many questions and (some) answers on tunneling-nanotube medicated RNA transfer between mammalian cells" Gal Haimovich, Ph.D. Assistant Staff Scientist Department of Molecular Genetics Weizmann Institute of Science Virtual only: zoom link Abstract: RNAs have been shown to undergo transfer between mammalian cells, though the mechanism behind this phenomenon...
"A Complicated Family: Conserved & Distinct Functions of tRNA Methyltransferases from Yeast to Humans" Jane Jackman, Ph.D. Professor of Chemistry & Biochemistry Ohio State University In-person: BSRB, ABC seminar rooms / zoom link Abstract: RNA modifications are now known to be a ubiquitous and important feature of cellular RNAs. tRNA are among the most heavily...
