RNA Innovation Seminar: Zhonggang Hou & Jun Hee Lee
"Harnessing diverse compact CRISPR-Cas3 for long-range genome engineering" Zhonggang Hou, Ph.D. Research Investigator Biological Chemistry ABSTRACT: Leading CRISPR-Cas technologies employ Cas9 and Cas12 enzymes that generate RNA-guided dsDNA breaks. Yet, the most abundant microbial adaptive immune systems, Type I CRISPR, is under-exploited for eukaryotic application. I will discuss our effort on adopting the first minimal...