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RNA Faculty Candidate Seminar: Rachel Niederer, Yale School of Medicine
Monday, January 10 @ 4:00 pm - 5:00 pm
“Uncovering novel translational control elements within 5′ UTRs”
Rachel Niederer, Ph.D.
Yale School of Medicine
Co-Hosts: The Center for RNA Biomedicine, Department of Biological Chemistry, and the Department of Human Genetics
In-person: Biomedical Science Research Buliding (BSRB), ABC Seminar rooms
Abstract: Translational control of gene expression plays an essential role during development, response to stress and a wide range of cellular processes. However, the key mRNA features that distinguish efficiently translated from poorly translated mRNAs remain largely unknown. This talk will describe the development of direct analysis of ribosome targeting (DART) and its use both in discovering novel regulatory elements within 5′ untranslated regions (5′ UTRs) as well as revealing unexpected behaviors from features that were previously thought to be well understood.