"Harnessing diverse compact CRISPR-Cas3 for long-range genome engineering" Zhonggang Hou, Ph.D. Research Investigator Biological Chemistry ABSTRACT: Leading CRISPR-Cas technologies employ Cas9 and Cas12 enzymes that generate RNA-guided dsDNA breaks. Yet, the most abundant microbial adaptive immune systems, Type I CRISPR, is under-exploited for eukaryotic application. I will discuss our effort on adopting the first minimal...
“Resolving the localisation and dynamics of mRNA and protein synthesis within neurons” Paul Donlin-Asp, Ph.D. Postdoctoral Researcher Department of Synaptic Plasticity Max Planck Institute for Brain Research Flyer in PDF Co-Host: The Department of Molecular, Cellular, and Developmental Biology Hybrid Seminar: In-person: Biomedical Science Research Building (BSRB), ABC Seminar rooms Zoom: https://umich.zoom.us/webinar/register/WN_tZjYxppSQwaDVTYIuC0jkw...
“Modulation of the MALT1 pre-mRNA structure by hnRNP proteins regulates T cell activation” Dr. Alisha 'Jonesy' Jones Postdoctoral Researcher Institute of Structural Biology Helmholtz Zentrum Munich Flyer in PDF Co-Hosts: The Center for RNA Biomedicine, Department of Biological Chemistry, and the Program in Biophysics Hybrid Seminar: In-person: Biomedical Science Research Buliding (BSRB), ABC...
“Uncovering novel translational control elements within 5' UTRs” Rachel Niederer, Ph.D. Postdoctoral Researcher Yale School of Medicine Co-Hosts: The Center for RNA Biomedicine, Department of Biological Chemistry, and the Department of Human Genetics Hybrid Seminar: In-person: Biomedical Science Research Buliding (BSRB), ABC Seminar rooms Zoom: https://umich.zoom.us/webinar/register/WN_qg4fyCUbQZyVu0oGrBLmWQ Abstract: Translational control of gene expression plays an essential...
“The scanning mechanism of mRNA translation initiation in humans” Jailson (Jay) Brito Querido, Ph.D. Postdoctoral Scientist MRC Laboratory of Molecular Biology Cambridge, UK Co-Hosts: The Center for RNA Biomedicine, Department of Biological Chemistry, and the Program in Biophysics Hybrid Seminar: In-person: Biomedical Science Research Building (BSRB), ABC Seminar rooms Zoom: https://umich.zoom.us/webinar/register/WN_pcS-fWIdSS-hDnKzoRhXeg Keywords: mRNA,...
"Mechanisms of co-transcriptional ribonucleoprotein assembly” Margaret (Maggie) Rodgers, Ph.D. Postdoctoral Researcher Johns Hopkins University Co-Hosts: The Center for RNA Biomedicine, Department of Biological Chemistry, and the Program in Biophysics Hybrid Seminar: In-person: Biomedical Science Research Buliding (BSRB), ABC Seminar rooms Zoom: https://umich.zoom.us/webinar/register/WN_Icqg8jRbQNGCBEFkj_u5Gw Keywords: RNA, RNP, ribosome assembly, transcription, single-molecule fluorescence Seminar flyer...
“Translating the cancer genome: dark matter proteins” John Prensner, M.D., Ph.D. Physician, Dana-Farber/Boston Children's Cancer and Blood Disorders Center Instructor of Pediatrics, Harvard Medical School Co-Hosts: The Center for RNA Biomedicine, Department of Computational Medicine & Bioinformatics, and Department of Pediatric Oncology Hybrid Seminar: In-person: Biomedical Science Research Building (BSRB), ABC Seminar rooms...
Inaugural RNA Therapeutics Seminar Michelle Hastings, Ph.D. Professor, Cell Biology and Anatomy; Director, Center for Genetic Diseases Rosalind Franklin University of Medicine and Science This is an internal U-M event: In-person: Palmer Commons, Forum Hall Zoom: https://umich.zoom.us/webinar/register/WN_mUj40sudTwmI6hXANnlJEg Keywords: pre-mRNA splicing, Antisense oligonucleotides, Usher syndrome, Batten Disease, lysosomal storage diseases Seminar flyer in...
"Unexpected determinants of neuronal identity and properties: the curious cases of PTBP1, PTBP2, and neuronal splicing" Sika Zheng, Ph.D. Associate Professor, Director of Center for RNA Biology and Medicine UC Riverside, School of Medicine Flyer in PDF Virtual Seminar Zoom: https://umich.zoom.us/webinar/register/WN_dltbxWdHQ5KrC3rTl4hqLQ Abstract: Alternative splicing is the major contributor to transcriptome diversity, but splicing...
“An Academic Approach to Oligonucleotide Therapeutics” Daniel O’Reilly Ph.D., MRSC Post-Doctoral Associate Khvorova Lab RNA Therapeutics Institute University of Massachusetts Medical School Flyer in PDF HYBRID SEMINAR: In-person: BSRC, ABC seminar rooms Zoom: https://umich.zoom.us/webinar/register/WN_dM1a1aKVTM2KfwiieutOWg Keywords: Oligonucleotides, Chemical Modifications, RNA, Huntington’s Disease Abstract: Nucleic acids (NA) are becoming the third major pillar of therapeutic modalities...
