Single Molecule Analysis in Real-Time (SMART) Center

The SMART (Single Molecule Analysis in Real-Time) Center is an NSF-seeded, shared-use facility providing university researchers with single molecule detection and manipulation tools to track and analyze biomolecules with unprecedented detail. The SMART Center provides access to state-of-the-art instrumentation, including single molecule spectroscopy and imaging, laser tweezers, and atomic force microscopy; as well as experienced support in experimental planning and analysis.

We would also be happy to give your group a short demonstration of our capabilities and discuss potential applications.


Services Offered

  • Single molecule fluorescent imaging and tracking
  • Fluorescence lifetime imaging
  • Fluorescence correlation spectroscopy
  • Force spectroscopy
  • Atomic force microscopy
  • Optical tweezers

Assistance with

  • Experimental planning
  • Data Acquisition
  • Data Analysis

Equipment Provided

  • TIRF / HILO fluorescence microscope with multicolor EMCCD cameras
  • ISS Alba time-resolved confocal microscope
  • AFM Workshop TT-AFM atomic force microscope
  • MiniTweezers optical tweezers
  • Single Particle Nanomanipulator optical tweezers + fluorescence microscope
  • Image analysis and particle tracking software

Areas of expertise

  • Single molecule techniques
  • Fast high-resolution fluorescent imaging
  • Single particle fluorescent tracking
  • Fluorescence lifetime imaging
  • Force spectroscopy
  • Experimental planning
  • Single molecule data analysis
  • Training

Who we serve
University of Michigan and external academic & commercial researchers in all scientific areas, with an added emphasis on RNA Biomedicine.

Damon Hoff
Phone: (734) 763-5449
SMART Center Brochure

Room 3080 Chemistry
930 N. University Avenue
Ann Arbor, MI 48109

College: LSA, Biophysics

Photo: Dr. Pitchiaya in the SMART lab using lasers