Seminar

“Uncovering novel translational control elements within 5' UTRs” Rachel Niederer, Ph.D. Postdoctoral Researcher Yale School of Medicine   Co-Hosts: The Center for RNA Biomedicine, Department of Biological Chemistry, and the Department of Human Genetics Hybrid Seminar: In-person: Biomedical Science Research Buliding (BSRB), ABC Seminar rooms Zoom: https://umich.zoom.us/webinar/register/WN_qg4fyCUbQZyVu0oGrBLmWQ Abstract: Translational control of gene expression plays an essential...

“The scanning mechanism of mRNA translation initiation in humans” Jailson (Jay) Brito Querido, Ph.D. Postdoctoral Scientist MRC Laboratory of Molecular Biology Cambridge, UK       Co-Hosts: The Center for RNA Biomedicine, Department of Biological Chemistry, and the Program in Biophysics Hybrid Seminar: In-person: Biomedical Science Research Building (BSRB), ABC Seminar rooms Zoom: https://umich.zoom.us/webinar/register/WN_pcS-fWIdSS-hDnKzoRhXeg Keywords: mRNA,...

"Mechanisms of co-transcriptional ribonucleoprotein assembly” Margaret (Maggie) Rodgers, Ph.D. Postdoctoral Researcher Johns Hopkins University         Co-Hosts: The Center for RNA Biomedicine, Department of Biological Chemistry, and the Program in Biophysics Hybrid Seminar: In-person: Biomedical Science Research Buliding (BSRB), ABC Seminar rooms Zoom: https://umich.zoom.us/webinar/register/WN_Icqg8jRbQNGCBEFkj_u5Gw Keywords: RNA, RNP, ribosome assembly, transcription, single-molecule fluorescence Seminar flyer...

“Translating the cancer genome: dark matter proteins” John Prensner, M.D., Ph.D. Physician, Dana-Farber/Boston Children's Cancer and Blood Disorders Center Instructor of Pediatrics, Harvard Medical School     Co-Hosts: The Center for RNA Biomedicine, Department of Computational Medicine & Bioinformatics, and Department of Pediatric Oncology Hybrid Seminar: In-person: Biomedical Science Research Building (BSRB), ABC Seminar rooms...

Inaugural RNA Therapeutics Seminar Michelle Hastings, Ph.D. Professor, Cell Biology and Anatomy; Director, Center for Genetic Diseases Rosalind Franklin University of Medicine and Science       This is an internal U-M event: In-person: Palmer Commons, Forum Hall Zoom: https://umich.zoom.us/webinar/register/WN_mUj40sudTwmI6hXANnlJEg Keywords: pre-mRNA splicing, Antisense oligonucleotides, Usher syndrome, Batten Disease, lysosomal storage diseases Seminar flyer in...

"Unexpected determinants of neuronal identity and properties: the curious cases of PTBP1, PTBP2, and neuronal splicing" Sika Zheng, Ph.D. Associate Professor, Director of Center for RNA Biology and Medicine UC Riverside, School of Medicine   Flyer in PDF   Virtual Seminar Zoom: https://umich.zoom.us/webinar/register/WN_dltbxWdHQ5KrC3rTl4hqLQ Abstract: Alternative splicing is the major contributor to transcriptome diversity, but splicing...

“An Academic Approach to Oligonucleotide Therapeutics” Daniel O’Reilly Ph.D., MRSC Post-Doctoral Associate Khvorova Lab RNA Therapeutics Institute University of Massachusetts Medical School Flyer in PDF   HYBRID SEMINAR: In-person: BSRC, ABC seminar rooms Zoom: https://umich.zoom.us/webinar/register/WN_dM1a1aKVTM2KfwiieutOWg Keywords: Oligonucleotides, Chemical Modifications, RNA, Huntington’s Disease Abstract: Nucleic acids (NA) are becoming the third major pillar of therapeutic modalities...

"RNA Structures, Interactions and Modifications" Zhipeng Lu (鲁志鹏), Ph.D. Assistant Professor Pharmacology and Pharmaceutical Sciences University of Southern California   Flyer in PDF In-person: BSRB, ABC seminar rooms / hybrid link Abstract: RNA in living cells are in constant motion, form dynamic structures, and interact with many molecules, including other RNAs. Direct determination of RNA...

"Meet the neighbors: A universal technology for probing RNA-interactions and RNA-scaffolded subcellular compartments in situ" David Shechner Ph.D. Assistant Professor of Pharmacology University of Washington   Flyer in PDF In-person: BSRB, ABC seminar rooms / hybrid link Keywords: RNA, proximity-biotinylation, subcellular architecture, nuclear architecture, spatial biology, biomolecular condensates, interactomics, nucleolus, Xist.   Abstract: In the context...

"Roadblocks on mRNAs? Gene Expression Regulation by Upstream Open Reading Frames in Plants" Polly Hsu, Ph.D. Assistant Professor Biochemistry and Molecular Biology Michigan State University     Flyer in PDF In-person: BSRB, ABC seminar rooms / hybrid link Keywords: translation, uORFs, nonsense-mediated decay Abstract: 30-70% of mRNAs in humans, mice and plants contain short ORFs,...