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RNA Innovation Seminar: Laura Scott, Ph.D., University of Michigan School of Public Health
Monday, October 21 @ 4:00 pm - 5:00 pm
“Regulation of RNA levels in muscle and adipose tissues by sex and genetic variants”
Laura Scott, Ph.D.
Research Professor, Biostatistics
University of Michigan School of Public Health
Research interests:
Dr. Scott uses a combination of bulk and single nucleus omic data – RNA expression, chromatin accessibility, metabolites and DNA methylation – to understand the cellular genetic regulatory landscape and to infer biological connections between genetic variation and disease risk.
Click here to read more about Dr. Scott and her work in a 2020 Faculty Spotlight article.
In-person: BSRB, Kahn Auditorium / hybrid link
Abstract:
Gene expression is regulated by multiple factors including genetic variation, sex, and cell type. I will describe differences by sex in human skeletal muscle cell type composition, cell type-level gene expression and chromatin accessibility, and bulk miRNA expression in 287 people. I will describe regulation of subcutaneous adipose gene expression by genetic variants in a meta-analysis of >2,200 people. These studies help to better understand transcription and post-transcriptional regulation of gene expression by sex and genetic regulation of gene expression.