“Dynamics of co-transcriptional pre-mRNA processing and assembly of related biomolecular condensates”

Prof. Karla Neugebauer, Ph.D.
Professor of Molecular Biophysics and Biochemistry and of Cell Biology
Director of Graduate Studies, Molecular Biophysics and Biochemistry
Director, Yale Center for RNA Science and Medicine
Yale School of Medicine

ZOOM

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FLYER IN PDF

Abstract: My lab is interested in the coordination between transcription, RNA processing and nuclear organization that governs gene expression. We have established experimental systems in budding yeast, zebrafish embryos, and mammalian tissue culture cells to explore transcription and splicing regulation in a variety of biological contexts and with a diversity of tools, from imaging to genome-wide approaches. Our observations have provided novel insights into transcription and splicing mechanisms as well as principles of cellular organization that facilitate efficient gene expression. In this talk, I will be discussing rapid co-transcriptional splicing during erythropoiesis and how Cajal bodies assemble to ensure a steady supply of spliceosomal components.