"Turning Bugs into Features: Engineering and Evolving Insect Symbiont-Mediated RNA Interference" Jeffrey Barrick, Ph.D. Associate Professor of Molecular Biosciences University of Texas at Austin In-person: BSRB, ABC seminar rooms / hybrid link Abstract: Many insects have co-evolved associations with microbial symbionts that are more consequential than our relationship with the human microbiome. These...
https://youtu.be/7exeVt7CaE4 "Awakenings" (1990) The victims of an encephalitis epidemic many years ago have been catatonic ever since, but now a new drug offers the prospect of reviving them. Join us for a pre-film panel discussion at 6:00 PM with neurology and neurologic disease physicians and scientists from University of Michigan's Center for RNA Biomedicine: Michelle...
"Engineer and deliver nucleic acid immunotherapeutics and vaccines – a focus on small circular mRNA (circRNA) vaccines" Guizhi (Julian) Zhu, Ph.D. Ara G. Paul Associate Professor of Pharmaceutical Science University of Michigan In-person: BSRB, ABC Seminar Rooms / hybrid link Abstract: Our ultimate research goal is to develop clinically translatable nucleic acid therapeutics and...
"Bacterial Small RNAs: Regulatory Circuits, On & Off Switches, & Quality Control" Susan Gottesman, Ph.D. Chief, Laboratory of Molecular Biology NIH/NCI Distinguished Investigator In-person: BSRB, ABC Seminar Rooms / hybrid link Abstract: Bacteria use small regulatory RNAs (sRNAs) and the RNA chaperone Hfq to regulate mRNA translation and stability, akin to miRNAs and...
"Locking Rho up" Irina Artsimovitch, Ph.D. Arts & Sciences Distinguished Professor Department of Microbiology The Ohio State University In-person: BSRB, ABC seminar rooms / hybrid link Abstract: Bacterial termination factor Rho co-transcriptionally surveils the nascent RNA and releases damaged and junk transcripts from RNA polymerase. During rapid growth, Rho maintains the transcriptome health, but how is Rho...
"The Invisible Dance of CRISPR-Cas9 through Molecular Space and Time" George Lisi, Ph.D. Thomas J. & Alice M. Tisch Assistant Professor Department of Molecular Biology, Cell Biology & Biochemistry Brown University In-person: BSRB, ABC seminar rooms / hybrid link Abstract: This talk will focus on long-range signaling in CRISPR-Cas9, a cutting-edge genome editing tool....
"Mis-splicing in repeat expansion diseases and development of potential therapeutics" Andy Berglund, Ph.D. Empire Professor of Innovation Director of the RNA Institute University at Albany In-person: BSRB, ABC Seminar Rooms / hybrid link Abstract: Repeat or microsatellite expansions are responsible for more than 50 human diseases. Myotonic dystrophy (DM), amyotrophic lateral sclerosis (ALS), and...
"Noncoding RNA Targets in Heart Failure" Anthony Rosenzweig, M.D. Professor of Internal Medicine Director of the MM Institute of Heart & Brain Health University of Michigan In-person: BSRB, ABC seminar rooms / hybrid link Abstract: TBA
"How chaperones help RNAs choose the right partner" Sarah Woodson, Ph.D. T.C. Jenkins Professor of Biophysics Johns Hopkins University In-person: BSRB, ABC seminar rooms / hybrid link Abstract: Non-coding RNAs must fold into specific structures to create the machinery for protein synthesis or to control gene expression. As nascent transcripts can form different base...
"RNA-RNA Base Pairing: Key to unlocking the functions of many noncoding RNAs" Joan Steitz, Ph.D. Sterling Professor of Molecular Biophysics and Biochemistry Yale University In-person: BSRB, ABC seminar rooms / hybrid link Abstract: Dr. Steitz's talk will be primarily historical, with many examples of discoveries of RNA-RNA base pairing over her 50-year+ career being...
