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RNA Innovation Seminar: Jeff Twiss, University of South Carolina
Monday, February 1 @ 4:00 pm - 5:00 pm
“Regulating the axonal proteome through mRNA transport and translation”
Jeffrey L. Twiss, M.D., Ph.D.
SmartState Chair in Childhood Neurotherapeutics
Professor of Biological Sciences
University of South Carolina
REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_Rss4i-7WTwyf8m8ogCPXEQ
Abstract: Neurons are extremely polarized cells with axonal and dendritic processes extending 100 to 1000 fold longer or more than the cell body diameter. Our lab has been interested in how axons grow to such great distances and how they respond to injury. mRNAs are transported into axons, with their localized translation providing the axon with autonomy to respond to different stimuli by modifying their local proteome. Transport, translation, and stability of axonal mRNAs is driven by interactions with RNA binding proteins and different signaling cascades. I will focus on recent work that gives insight into how specificity of these mechanisms is driven for different cohorts of axonal mRNAs.
Keywords: Neuron, Axon, RNA transport, Translational regulation