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RNA Innovation Seminar: Evgeny Nudler, New York University

Monday, March 18 @ 4:00 pm - 5:00 pm

“Transcription-driven DNA Repair”
Evgeny Nudler, Ph.D.

Julie Wilson Anderson Professor of Biochemistry
Investigator, Howard Hughes Medical Institute
Department of Biochemistry & Molecular Pharmacology
NYU Grossman School of Medicine


In-person: BSRB, ABC seminar rooms / hybrid link

Abstract: Using E. coli as a model system, we have developed new approaches to study damage recognition and processing in vivo for three major DNA repair pathways, nucleotide excision repair (NER), ribonucleotide excision repair (RER), and base excision repair (BER). Our recent findings let us to formulate a conceptually new model of global transcription-driven repair (TDR), in which RNA polymerase serves as the indispensable genome-wide DNA damage sensor and also delivery vehicle and platform for the assembly of specialized repair complexes in living cells. The model provides a framework for better understanding genotoxic stress response and genome instability in bacteria and beyond.
Keywords: DNA repair, transcription elongation, RNA polymerase, ppGpp, NER, BER, RER


Monday, March 18
4:00 pm - 5:00 pm