BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Center for RNA Biomedicine - ECPv6.15.17//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Center for RNA Biomedicine
X-ORIGINAL-URL:https://rna.umich.edu
X-WR-CALDESC:Events for Center for RNA Biomedicine
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Detroit
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20230312T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20231105T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20240310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20241103T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20250309T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20251102T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20240912T090000
DTEND;TZID=America/Detroit:20240912T123000
DTSTAMP:20260419T073556
CREATED:20240904T135915Z
LAST-MODIFIED:20240904T135915Z
UID:15226-1726131600-1726144200@rna.umich.edu
SUMMARY:David R. Walt\, Ph.D. — Special Lecture and Open House Breakfast
DESCRIPTION:The Center for RNA Biomedicine presents microwell array pioneer\, David R. Walt\, PH.D.\n \nOn Thursday\, September 12\, the Center for RNA Biomedicine will host life sciences industry expert David R. Walt\, Ph.D. for a special lecture titled\, “Why sensitivity matters for clinical diagnosis (see abstract below).” \nFollowing the lecture\, there will be an open house breakfast with opportunities to socialize with peers and connect with Dr. Walt. \nSchedule — Thursday\, September 12 | 9 a.m. – 12:30 p.m.\n9 a.m. – 10:15 a.m. | David Walt\, Ph.D. Lecture — Koessler Room\, 3rd Floor\, Michigan League\n10:30 a.m. – 12:30 p.m. | Open House Breakfast with Dr. Walt — Henderson Room (directly across from Koessler)\, 3rd Floor\, Michigan League\n**A hybrid option is being offered via Zoom — click here to register.** \nWhether in person or virtual\, we hope you’ll join us for learning\, coffee\, and socializing with one of the top minds in fields of bio-inspired engineering\, RNA-based clinical diagnosis\, and life sciences startups. \nAbstract and Speaker Info\nAbstract:\nA major challenge for many clinical diagnostic applications is the quantification of low-abundance proteins and other biomolecules in biological fluids. For example\, traditional techniques\, such as enzyme-linked immunosorbent assay (ELISA)\, can only measure several hundred proteins in human blood\, which is limiting because there are thousands of proteins present at low concentrations that are of potential diagnostic utility. Single-molecule technologies allow for digital counting of individual protein molecules and have enabled 1000-fold increases in sensitivity over conventional protein detection methods. We have pioneered the development of these technologies that provide for multiplexed measurements with femtomolar sensitivities or below. I will discuss the technologies and describe their application to neurodegenerative disease\, cancer\, and infectious diseases. \nAbout David R. Walt\, Ph.D.:\nDavid R. Walt is the Hansjörg Wyss Professor of Bioinspired Engineering at Harvard Medical School\, Professor of Pathology at Brigham and Women’s Hospital and Harvard Medical School\, Core Faculty Member of the Wyss Institute at Harvard University\, Associate Member at the Broad Institute\, and is a Howard Hughes Medical Institute Professor. His lab’s research focuses on creating and using novel technologies to solve unmet clinical diagnostics problems. Walt is the Scientific Founder of Illumina Inc.\, Quanterix Corp.\, and has co-founded multiple other life sciences startups including Ultivue\, Inc.\, Arbor Biotechnologies\, Sherlock Biosciences\, Vizgen\, Inc.\, and Protillion Biosciences. He has received numerous national and international awards and honors for his fundamental and applied work in the field of optical microwell arrays and single molecules including the 2023 National Academy of Engineering’s Fritz J. and Dolores H. Russ Prize and the 2021 Kabiller Prize in Nanoscience and Nanomedicine. He is a member of the U.S. National Academy of Engineering\, the U.S. National Academy of Medicine\, a Member of the American Philosophical Society\, a Fellow of the American Academy of Arts and Sciences\, a Fellow of the American Institute for Medical and Biological Engineering\, a Fellow of the American Association for the Advancement of Science\, a Fellow of the National Academy of Inventors\, and is inducted in the US National Inventors Hall of Fame. \n 
URL:https://rna.umich.edu/events/david-r-walt-ph-d-special-lecture-and-open-house-breakfast/
LOCATION:Michigan League\, 911 N University\, Ann Arbor\, MI\, 48109\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20240923T160000
DTEND;TZID=America/Detroit:20240923T170000
DTSTAMP:20260419T073556
CREATED:20240909T175207Z
LAST-MODIFIED:20240917T190224Z
UID:15242-1727107200-1727110800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Gregor Neuert\, Ph.D. — Vanderbilt University
DESCRIPTION:The University of Michigan Center for RNA Biomedicine Seminar Series is excited to host Gregor Neuert\, Ph.D.\, for the first talk of the 2024 – 2025 RNA Innovation Seminar Series.\n\nGregor Neuert\, Ph.D.\nAssociate Professor\,\nMolecular Physiology and Biophysics\nBiomedical Engineering\,\nPharmacology\nVanderbilt University\n  \nDate and Time: Monday\, September 23 | 4 p.m.\nIn-person: Kahn Auditorium\, BSRB\nVirtual: The seminar will be available via Zoom for those unable to attend in person. Click here to register for the Zoom. \nTalk Title: “Transcriptional stochasticity reveals multiple mechanisms of long non-coding RNA regulation”\n\nAbstract:\nLong noncoding RNAs (LncRNAs) are increasingly recognized as being involved in human physiology and diseases\, but there is a lack of mechanistic understanding for the majority of lncRNAs. We comparatively tested proposed mechanisms of antisense lncRNA regulation at the X-chromosome Inactivation (XCI) locus. Our single-cell analyses argue against mechanisms that require the Xist or Tsix transcript to bind to each other. Intriguingly\, we find that due to stochasticity in transcription\, different mechanisms based on the act of transcription regulate Xist and Tsix at different levels of nascent transcription. At medium levels\, RNA polymerases transcribe Xist and Tsix on each strand at the same transcription site and deposit significant amounts of the histone mark H3K36me3\, which inhibits Xist. At high levels of nascent transcription\, many RNA polymerases transcribe Xist or Tsix resulting in transcriptional interference. Therefore\, lncRNA expression variability is not just a quirk of transcription but an important aspect of regulation that allows multiple mechanisms to be employed by the same gene locus within the same cell population. \nPlease visit the Neuert Lab for Quantitative Systems Biology website to learn more about Dr. Neuert and his work. \n 
URL:https://rna.umich.edu/events/rna-innovation-seminar-gregor-neuert-vanderbilt-university/
LOCATION:BSRB – ABC Seminar rooms\, 109 Zina Pitcher Pl\, Ann Arbor\, MI\, 48109\, United States
END:VEVENT
END:VCALENDAR