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X-WR-CALDESC:Events for Center for RNA Biomedicine
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SUMMARY:RNA Innovation Seminar: Guizhi (Julian) Zhu\, University of Michigan
DESCRIPTION:“Engineer and deliver nucleic acid immunotherapeutics and vaccines – a focus on small circular mRNA (circRNA) vaccines”\nGuizhi (Julian) Zhu\, Ph.D.\nAra G. Paul Associate Professor of Pharmaceutical Science\nUniversity of Michigan \n  \nIn-person: BSRB\, ABC Seminar Rooms / hybrid link \nAbstract: Our ultimate research goal is to develop clinically translatable nucleic acid therapeutics and vaccines\, along with their delivery systems. In this talk\, we will mainly discuss small circular mRNA (circRNA) vaccines for cancer immunotherapy and the prevention of infectious diseases. Modification-free small circRNA vaccines are highly stable and sequence-defined with unique innate immunomodulatory mechanisms and sustained production of concatemeric antigens\, resulting in robust and long-lasting adaptive immunity. Relative to several state-of-the-art modified mRNAs\, nanocarrier-delivered circRNA vaccines elicited up to 10-fold antigen-specific T cells in mice\, with superior T cell memory and vaccine safety. circRNA vaccines are widely applicable for tumor and viral (neo)antigens to elicit potent and long-lasting CD8+/CD4+ T cell responses in young or immunosenescent aged mice. Combining circRNA vaccines with immune checkpoint blockade (ICB) reduced tumor immunosuppression and eradicated multiple types of murine tumors\, including ICB-resistant BrafV600E melanoma. Moreover\, pulmonary delivery of influenza circRNA vaccines protected mice from influenza challenge. Overall\, small circRNA vaccines are promising for versatile applications. Lastly\, we will also briefly discuss our research in cGAS-STING- and ADAR1- related nucleic acid therapeutics and drug delivery systems for cancer and autoimmune diseases.
URL:https://rna.umich.edu/events/guizhi-julian-zhu/
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DTSTART;TZID=America/Detroit:20231023T160000
DTEND;TZID=America/Detroit:20231023T170000
DTSTAMP:20260425T181004
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LAST-MODIFIED:20231010T174315Z
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SUMMARY:RNA Innovation Seminar: Susan Gottesman\, NIH/NCI
DESCRIPTION:“Bacterial Small RNAs: Regulatory Circuits\, On & Off Switches\, & Quality Control”\nSusan Gottesman\, Ph.D.\nChief\, Laboratory of Molecular Biology\nNIH/NCI Distinguished Investigator \n  \n  \nIn-person: BSRB\, ABC Seminar Rooms / hybrid link \nAbstract: Bacteria use small regulatory RNAs (sRNAs) and the RNA chaperone Hfq to regulate mRNA translation and stability\, akin to miRNAs and the RISC complex in eukaryotes. The approaches to defining bacterial sRNAs and their targets have dramatically improved since the screens that first identified many of them over 20 years ago. Current tools provide a global view of Hfq-binding RNAs that suggests increasingly interwoven regulatory networks\, helping cell respond appropriately to stress and host interactions. On-switches for sRNAs are primarily at the level of transcription; when transcription ceases\, most of the sRNAs are used stoichiometrically\, being degraded as they are used\, providing an effective Off-switch for sRNA regulation. We have used genetic screens to identify novel regulators of both Hfq and the sRNAs. One of these\, HqbA\, binds directly to the distal face of Hfq\, and competes with weakly binding RNAs for association with Hfq\, suggesting it is a new quality control regulator for Hfq. Data suggests that this is a bifunctional protein\, directly regulating Hfq by protein-protein interaction and regulating other processes independently of Hfq. HqbA\, along with other factors\, help to ensure appropriate hierarchy of sRNA function. \nKeywords: mRNA translation; RNAse E; Escherichia coli.
URL:https://rna.umich.edu/events/susan-gottesman/
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