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SUMMARY:RNA Innovation Seminar: Haiyuan Yu\, Cornell University
DESCRIPTION:“Dissect Enhancer Architecture and Map Regulatory Genomic Landscape Across Diverse Cell and Tissue Types Through Nascent Transcriptome Studies”\nHaiyuan Yu\, Ph.D.\nTisch University Professor\nDepartment of Biological Statistics and Computational Biology\nWeill Institute for Cell and Molecular Biology\nDirector\, Center for Innovative Proteomics (CIP@Cornell)\nIn-person: BSRB\, ABC seminar rooms / hybrid link \nAbstract: Recent studies have shown that both enhancers and promoters can recruit RNA pol II and initiate transcription. The short half-life nature of enhancer RNAs (eRNAs) makes detection of distal initiation events challenging. Through systematic comparison of RNA sequencing assays\, we find that nascent transcriptome assays\, PRO-cap and PRO-seq\, have great sensitivity and specificity in detecting eRNA transcription genome-wide. In fact\, we find that\, unlike histone marks\, divergent transcription of eRNAs is a critical mark for all active enhancers genome-wide. Moreover\, nascent transcription precisely delineates the sequence architecture of enhancers\, whereby transcription start sites (TSSs) serve as critical anchors in revealing motif positioning within enhancers and their boundaries. By leveraging our high precision and sensitivity nascent transcriptome PRO-cap and PRO-seq assays\, we mapped the active transcriptional regulatory landscape across ~200 tissue and cell types of the human body with unprecedented resolution and depth. This information is used to quantify gene transcriptional activity and to identify and delineate transcription regulatory elements\, including both enhancers and promoters that are cell-type-specific and ubiquitous. These findings are critical in modeling putative enhancer-promoter connectivity and in speeding the identification of potential disease-associated noncoding variants in regulatory regions.
URL:https://rna.umich.edu/events/haiyuan-yu/
LOCATION:MI
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CREATED:20221202T153751Z
LAST-MODIFIED:20230410T185444Z
UID:10725-1681747200-1681750800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Julius B. Lucks\, Northwestern University
DESCRIPTION:“RNA Synthetic Biology: Towards an Era of RNA Design for Biology & Global Health”\nJulius B. Lucks\, Ph.D.\nProfessor & Associate Chair\, Chemical & Biological Engineering\nCo-Director\, Center for Synthetic Biology\nNorthwestern University\nIn-person: BSRB\, ABC seminar rooms / hybrid link \nAbstract: RNAs are emerging as a powerful substrate for engineering cellular behavior. As with all biomolecules\, RNA function is intimately related to its structure\, since RNA can adopt structures that selectively modulate gene expression. Central questions in biology & bioengineering then are: How do RNAs fold inside cells?; and How can we engineer these folds to control gene expression? In this talk\, I will present our work at the interface of these two questions and share results that are beginning to uncover design principles for understanding natural RNAs and engineering RNAs for an array of applications in biomanufacturing and human health. I will focus on our recent work in understanding how riboswitch RNAs make regulatory decisions “on the fly” during the process of transcription\, how we can use riboswitches as biosensors\, and our recent development of a new synthetic biology biosensing platform that allows rapid\, field-deployable diagnostics for a range of compounds important to our health and the environment. \nRNA\, RNA folding\, RNA synthetic biology\, Riboswitches\, Cell-Free Synthetic Biology
URL:https://rna.umich.edu/events/julius-b-lucks/
LOCATION:MI
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