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X-WR-CALDESC:Events for Center for RNA Biomedicine
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DTSTART;TZID=America/Detroit:20230213T120000
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DTSTAMP:20260420T234643
CREATED:20221102T123120Z
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SUMMARY:RNA Innovation Seminar: Gal Haimovich\, Weizmann Institute of Science
DESCRIPTION:“Why Did the RNA Cross the Nanotube? Many questions and (some) answers on tunneling-nanotube medicated RNA transfer between mammalian cells”\nGal Haimovich\, Ph.D. \nAssistant Staff Scientist\nDepartment of Molecular Genetics\nWeizmann Institute of Science\nVirtual only: zoom link \nAbstract: RNAs have been shown to undergo transfer between mammalian cells\, though the mechanism behind this phenomenon and its overall importance to cell physiology is not well understood. We found that full-length mRNAs and lncRNAs undergo direct cell-cell transfer via cytoplasmic extensions called tunneling nanotubes (TNTs)\, which connect donor and acceptor cells. Despite 10 years of research\, there are still major questions about this process such as which RNAs are transferred\, what is the mechanism\, how is this process regulated and what does the RNA do on the other side? I will review the evidence for TNT-mediated RNA transfer\, discuss the technical challenges in this field\, and provide some answers to these questions.
URL:https://rna.umich.edu/events/gal-haimovich/
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DTSTART;TZID=America/Detroit:20230227T160000
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CREATED:20221102T124955Z
LAST-MODIFIED:20230227T210355Z
UID:10674-1677513600-1677517200@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Jane Jackman\, Ohio State University
DESCRIPTION:“A Complicated Family: Conserved & Distinct Functions of tRNA Methyltransferases from Yeast to Humans”\nJane Jackman\, Ph.D.\nProfessor of Chemistry & Biochemistry\nOhio State University\nIn-person: BSRB\, ABC seminar rooms / zoom link \nAbstract: RNA modifications are now known to be a ubiquitous and important feature of cellular RNAs. tRNA are among the most heavily modified of RNA species\, with a large network of often highly conserved enzymes dedicated to introducing distinct modifications into specific subsets of tRNAs in each organism. The expanding number of technological approaches to mapping tRNA modifications has enabled an explosion of information about the types and locations of modifications in many biological systems\, but functional information about many modifications has lagged. The tRNA methyltransferase Trm10 is a SPOUT family RNA methyltransferase that is absolutely conserved throughout Archaea and Eukarya\, but exhibits markedly different substrate specificities for nucleotide and tRNA substrates in different biological contexts. However\, the molecular basis for these distinct substrate specificities has not been demonstrated. Moreover\, despite multiple phenotypes associated with loss of Trm10 N1-methylation\, including a role in human disease\, the biological impact of Trm10 modification is not understood. We have taken a comprehensive approach utilizing enzymes from diverse organisms from Archaea to humans and multiple eukaryotic model systems to identify conserved and unique mechanistic and functional features of this essential family of tRNA methyltransferases.
URL:https://rna.umich.edu/events/jane-jackman/
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