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X-WR-CALNAME:Center for RNA Biomedicine
X-ORIGINAL-URL:https://rna.umich.edu
X-WR-CALDESC:Events for Center for RNA Biomedicine
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210503T160000
DTEND;TZID=America/Detroit:20210503T170000
DTSTAMP:20260425T153628
CREATED:20210126T234652Z
LAST-MODIFIED:20210413T174229Z
UID:7841-1620057600-1620061200@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Olivia Rissland\, University of Colorado School of Medicine
DESCRIPTION:“Regulating the Regulators: Control of RNA Binding Proteins during Embryogenesis”\nOlivia Rissland\, Ph.D.\nAssistant Professor\nRNA Bioscience Initiative | Department of Biochemistry & Molecular Genetics\nUniversity of Colorado School of Medicine \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_vA9zYS5nSEenf8Zmt1f-qA \nFLYER IN PDF \n  \nABSTRACT: The maternal-to-zygotic transition (MZT) is a conserved step in animal development\, where control is passed from the maternal to the zygotic genome. Although the MZT is typically considered from its impact on the transcriptome\, we previously found that three maternally deposited Drosophila RNA binding proteins (ME31B\, Trailer Hitch [TRAL]\, and Cup) are also cleared during the MZT by unknown mechanisms. Here\, we show that these proteins are degraded by the ubiquitin-proteasome system. Marie Kondo\, an E2 conjugating enzyme\, and the E3 CTLH ligase are required for the destruction of ME31B\, TRAL\, and Cup. Structure modeling of the Drosophila CTLH complex suggests that substrate recognition is different than orthologous complexes. Despite occurring hours earlier\, egg activation mediates clearance of these proteins through the Pan Gu kinase\, which stimulates translation of Kondo mRNA. Clearance of the maternal protein dowry thus appears to be a coordinated\, but as-yet underappreciated\, aspect of the MZT.
URL:https://rna.umich.edu/events/olivia-rissland/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210504T150000
DTEND;TZID=America/Detroit:20210504T160000
DTSTAMP:20260425T153628
CREATED:20210416T182959Z
LAST-MODIFIED:20210416T182959Z
UID:8551-1620140400-1620144000@rna.umich.edu
SUMMARY:Seminar: Tatjana Trcek\, Johns Hopkins University
DESCRIPTION:Zoom link \n“RNA Granules: A View from the RNA Perspective”\nTatjana Trcek\, PhD\nAssistant Professor\nDepartment of Biology\nJohns Hopkins University\n  \nHosted by:\nStephanie Moon\, Ph.D.\nAssistant Professor of Human Genetics\nFaculty Scholar of the Center for RNA Biomedicine\nAffiliate Faculty\, Biological Chemistry\nFLYER IN PDF \nDepartment of Human Genetics Seminar \n  \n 
URL:https://rna.umich.edu/events/seminar-tatjana-trcek-johns-hopkins-university/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210505T090000
DTEND;TZID=America/Detroit:20210505T100000
DTSTAMP:20260425T153628
CREATED:20210104T143436Z
LAST-MODIFIED:20210426T152958Z
UID:7661-1620205200-1620208800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Cambridge RNA Club
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-tba-host-5/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210517T160000
DTEND;TZID=America/Detroit:20210517T170000
DTSTAMP:20260425T153628
CREATED:20210126T235922Z
LAST-MODIFIED:20210512T200602Z
UID:7845-1621267200-1621270800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Thomas Martinez\, Salk Institute for Biological Studies
DESCRIPTION:“Annotation and Characterization of Human Protein-coding Small Open Reading Frames”\nThomas Martinez\, Ph.D.\nPostdoctoral Fellow\nSalk Institute for Biological Studies \nZOOM \nREGISTRATION REQUIRED:\nhttps://umich.zoom.us/webinar/register/WN_90RkcQTGQZa7ifQ8kbSdNQ \nFLYER IN PDF \nKEYWORDS: microprotein\, smORF\, ribosome profiling \nABSTRACT: Functional protein-coding small open reading frames (smORFs) are emerging as an important class of genes. Several smORF-encoded microproteins have been characterized and implicated in a variety of critical processes\, including regulation of mRNA decay\, DNA repair\, and muscle formation. Thus\, rigorous and comprehensive annotation of protein-coding smORFs is critical to our understanding of basic biology and physiology\, as well as disease. We recently developed an improved workflow that integrates de novo transcriptome assembly and ribosome profiling to overcome obstacles with previous methods to more confidently annotate thousands of novel smORFs across multiple human cell lines\, including hundreds encoded on putative non-coding RNAs. Over 1\,500 smORFs are found in two or more cell lines\, and ~40% lack a canonical AUG start codon. Evolutionary conservation analyses suggest that hundreds of smORF-encoded microproteins are likely functional. We also find that smORF-derived peptides are detectable on human leukocyte antigen complexes\, positioning smORFs as a source of novel antigens. The annotation of protein-coding smORFs radically alters the current view of the human genome’s coding capacity and will provide a rich pool of unexplored\, functional human genes. \nBIOGRAPHY: Thomas received his B.S. in Biological Engineering from MIT and trained in Prof. JoAnne Stubbe’s laboratory\, where he studied the mechanism of ribonucleotide reductase. He then received his Ph.D. in Biochemistry & Molecular Biophysics from Caltech as an NIH NRSA predoctoral fellow under the mentorship of Prof. Peter Dervan. His thesis work focused primarily on characterizing the effects of DNA binding pyrrole-imidazole polyamides on DNA replication in prostate cancer cells. Thomas is currently an NIH NRSA postdoctoral fellow in Prof. Alan Saghatelian’s laboratory\, where he has developed an integrative platform combining ribosome profiling and de novo transcriptome assembly to discover functional smORF encoded microproteins in the human genome.
URL:https://rna.umich.edu/events/thomas-martinez/
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210518T160000
DTEND;TZID=America/Detroit:20210518T170000
DTSTAMP:20260425T153628
CREATED:20210517T161112Z
LAST-MODIFIED:20210517T163536Z
UID:8681-1621353600-1621357200@rna.umich.edu
SUMMARY:Seminar: Nick Ingolia\, UC Berkeley
DESCRIPTION:ZOOM LINK \n“Dissecting gene regulatory networks with CiBER-Seq”\nNicholas Ingolia\, PhD\nAssistant Professor\nDepartment of Molecular & Cell Biology\nUniversity of California\, Berkeley\nFaculty host:\nKristin Koutmou\, Ph.D.\nSeyhan N. Ege Assistant Professor of Chemistry\nDepartment of Chemistry\nDepartment of Chemistry Seminar \nABSTRACT: Cells integrate environmental signals and internal physiology to dynamically control gene expression. We have developed a technique to dissect this regulatory logic by linking targeted\, genome-wide genetic perturbations with a deep-sequencing readout that quantitatively measures the expression phenotype induced by each perturbation. Our approach combines CRISPR interference (CRISPRi) with barcoded expression reporters (CiBER-seq) to profile transcriptional\, translational\, and posttranslational regulatory responses\, connecting each guide in a genome-scale library with its individual phenotypic consequences. Applying CiBER-Seq to the well-studied integrated stress response (ISR) pathway recapitulated the known biology of this pathway and uncovered further triggers for ISR activation that were not previously appreciated. The quantitative phenotypic measurements from CiBER-Seq are well suited to epistasis analysis\, and we measure dual-perturbation phenotypes and compare patterns of genetic interaction to gain further insight into regulatory pathways. CiBER-Seq is an incisive tool for dissecting genetic networks\, and can be applied to study a wide range of biological processes\, using gene expression regulation as a sensitive and specific readout of the state of the cell. \n 
URL:https://rna.umich.edu/events/nick-ingolia-uc-berkeley/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210519T090000
DTEND;TZID=America/Detroit:20210519T100000
DTSTAMP:20260425T153628
CREATED:20210415T215014Z
LAST-MODIFIED:20210426T152937Z
UID:8528-1621414800-1621418400@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Groupe de Recherche RNA (GDR)
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-groupe-de-recherche-rna-gdr/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20210525
DTEND;VALUE=DATE:20210606
DTSTAMP:20260425T153628
CREATED:20210126T220010Z
LAST-MODIFIED:20210126T230016Z
UID:7829-1621900800-1622937599@rna.umich.edu
SUMMARY:26th Annual RNA Society Virtual meeting
DESCRIPTION:For more details\, visit: https://www2.rnasociety.org/conferences/rna-2021/ \n2021 ORGANIZERS: \nGene Yeo – University of California San Diego\, USA \nJörg Vogel – University of Würzburg\, Germany\nKatrin Karbstein – Scripps Research Institute\, Florida\, USA\nXavier Roca – Nanyang Technological University\, Singapore\nV. Narry Kim – Seoul National University\, South Korea\nAnna Marie Pyle – Yale University\, USA
URL:https://rna.umich.edu/events/26th-annual-rna-society-virtual-meeting/
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