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X-WR-CALDESC:Events for Center for RNA Biomedicine
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210405T160000
DTEND;TZID=America/Detroit:20210405T170000
DTSTAMP:20260427T044547
CREATED:20210126T233354Z
LAST-MODIFIED:20210310T173437Z
UID:7838-1617638400-1617642000@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Natoya Peart\, University of Pennsylvania
DESCRIPTION:“Direct binding of ESRP1 to regulated transcripts is required for position-dependent splicing regulation”\nNatoya Peart\, Ph.D.\nPostdoctoral Researcher – Carstens Lab/Lynch Lab\nDepartment of Medicine/Department of Biochemistry and Molecular Biophysics\nUniversity of Pennsylvania \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_0lUfePb0Qdac-cQZDpeiEQ \nFLYER IN PDF \nKEYWORDS: Alternative splicing\, RNAMap\, Esrp1 \nABSTRACT: Coordinated regulation of alternative splicing is essential to the establishment of cell identity. The Epithelial Splicing Regulatory Proteins (Esrps)\, ESRP1 and ESRP2\, are highly conserved paralogous proteins required for organogenesis of multiple organ systems and compromised function of Esrps contributes to human diseases and pathologies. Esrps are robustly expressed in the epithelial cells of the epidermis\, large and small intestines\, salivary glands\, stomach\, and a variety of other tissues\, where they are vital in promoting an epithelial splicing network. Although ESRP1 and ESRP2 share partial functional redundancy\, ESRP1 appears to play a larger role in regulating gene expression.\nUsing a combination of enhanced immunoprecipitation coupled with high throughput sequencing (eCLIP) in the epithelial cells of mouse epidermis and RNA sequencing analysis of alterations in splicing and total gene expression that result from epidermal ablation of Esrp1 and Esrp2 we generate a map of Esrp1 binding to RNA. We show that ESRP1 regulates splicing primarily through direct binding in a position-dependent manner to either promote exon inclusion or skipping. In particular\, we show that Esrp1 binding upstream of or withing alternatively spliced exons suppresses exon inclusion\, whilst binding downstream of the non-constitutive exon promotes exon inclusion. In addition\, we identified widespread binding of ESRP1 in 3’ and 5’ untranslated regions (UTRs) of genes enriched for epithelial cell function suggesting that it directly regulates post-transcriptional gene expression steps in addition to splicing.
URL:https://rna.umich.edu/events/natoya-peart/
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DTSTART;TZID=America/Detroit:20210406T120000
DTEND;TZID=America/Detroit:20210406T130000
DTSTAMP:20260427T044547
CREATED:20200826T131104Z
LAST-MODIFIED:20210405T190959Z
UID:6468-1617710400-1617714000@rna.umich.edu
SUMMARY:Seminar: Eva Nogales\, Ludwig Lecture
DESCRIPTION:“Exploring the Modularity of Large Complexes Involved in Transcription Initiation and Chromatin Modifications” \n\nEva Nogales\, PhD\nHoward Hughes Medical Institute investigator\, Professor of Biochemistry and Molecular Biology\nUniversity of California\, Berkeley \nSenior Faculty Scientist\nLawrence Berkeley National Laboratory\n \nDepartment of Biological Chemistry\, Ludwig Lecture
URL:https://rna.umich.edu/events/seminar-eva-nogales-ludwig-lecture/
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DTSTART;TZID=America/Detroit:20210407T160000
DTEND;TZID=America/Detroit:20210407T170000
DTSTAMP:20260427T044547
CREATED:20210104T143303Z
LAST-MODIFIED:20210127T001017Z
UID:7657-1617811200-1617814800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Bay Area RNA Club (BARC)
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-bay-area-rna-club-barc/
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210413T160000
DTEND;TZID=America/Detroit:20210413T170000
DTSTAMP:20260427T044547
CREATED:20210405T150818Z
LAST-MODIFIED:20210407T130407Z
UID:8417-1618329600-1618333200@rna.umich.edu
SUMMARY:Stephanie Moon\, Ph.D.\, "RNA regulation in proteotoxic stress and genetic neurological disorders"
DESCRIPTION:“RNA regulation in proteotoxic stress and genetic neurological disorders” \n\nStephanie Moon\, PhD\nAssistant Professor of Human Genetics\, a Faculty Scholar of the Center for RNA Biomedicine\, and an Affiliate Faculty of Biological Chemistry at the University of Michigan \nFaculty Host: Sundeep Kalantry\, PhD\, Associate Professor of Human Genetics \nZoom link: https://umich-health.zoom.us/j/92442599246 \nFLYER IN PDF \nCenter for Cell Plasticity and Organ Design Seminar
URL:https://rna.umich.edu/events/stephanie-moon/
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210419T160000
DTEND;TZID=America/Detroit:20210419T170000
DTSTAMP:20260427T044547
CREATED:20210128T141644Z
LAST-MODIFIED:20210310T212447Z
UID:7864-1618848000-1618851600@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Jailson (Jay) Brito Querido\, MRC Laboratory of Molecular Biology
DESCRIPTION:“Structural insights into mRNA translation initiation in humans”\nJailson (Jay) Brito Querido\, Ph.D.\nPostdoctoral Scientist\nMRC Laboratory of Molecular Biology\nCambridge\, UK \nZOOM \nFLYER IN PDF \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_78YYOhIhTbOBy2_JSdM7Wg \nABSTRACT: A key step in translational initiation is the recruitment of the 43S pre-initiation complex (43S PIC) by the cap-binding complex (eIF4F) at the 5´ end of mRNA. Eukaryotic initiation factors eIF1\, eIF1A\, eIF3\, eIF5\, and the ternary complex (TC) of eIF2–GTP–tRNAiMet bind to the 40S ribosomal subunit to form the 43S PIC. Once assembled\, the 43S PIC is recruited to the cap-binding complex eIF4F at the 5´end of mRNA to form a 48S initiation complex (48S). The 48S then scans along the mRNA to locate a start codon. To understand the mechanisms involved\, we determined the structure of a reconstituted human 48S using cryo-electron microscopy. The structure reveals insights into early events of translation initiation complex assembly. It reveals how eIF4F interacts with subunits of the eIF3 structural core near the mRNA exit channel in the 43S. The location of eIF4F is consistent with a slotting model of mRNA recruitment and suggests a “blind-region” that would preclude recognition of start sites upstream of the location of the P site at the point of recruitment. \nKEYWORDS: mRNA\, ribosome\, eIF4F\, eIF4A\, translation
URL:https://rna.umich.edu/events/jay-querido/
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210421T090000
DTEND;TZID=America/Detroit:20210421T100000
DTSTAMP:20260427T044547
CREATED:20210104T143404Z
LAST-MODIFIED:20210415T215048Z
UID:7659-1618995600-1618999200@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Shanghai RNA Club
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-tba-host-4/
CATEGORIES:Seminar
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