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SUMMARY:RNA Collaborative Seminar Series - NCI RNA Biology Initiative hosting
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-nci-rna-biology-initiative-hosting/
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UID:6382-1611565200-1611568800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Elena Conti\, Max Planck Institute of Biochemistry
DESCRIPTION:Talk title: The RNA exosome complex: the Dr Jekyll and Mr Hyde of RNA degradation\nElena Conti\, PhD\nDirector\, Max Planck Institute of Biochemistry\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_IjnWw1UcRkW8zcDeuAM2tQ \n  \nFlyer in PDF \nKeywords: molecular mechanisms\, RNA\, ribosome\, biochemistry\, cryo-EM\, X-ray crystallography \nAbstract: All RNAs in eukaryotic cells are eventually degraded. The RNA exosome is a conserved macromolecular machine that degrades a vast number and variety of RNAs. Exosome-mediated RNA degradation leads to the complete elimination of nuclear and cytoplasmic transcripts in turnover and quality control pathways\, and to the partial trimming of RNA precursors in nuclear processing pathways. How the exosome combines specificity and versatility to either eliminate or process RNAs has been a long-standing question. \nOver the years\, our group has used biochemical and structural approaches to understand how the exosome core complex channels RNA substrates for degradation and how it associates with its nuclear and cytoplasmic cofactors. Visualizing how the exosome cofactors interact with pre-ribosomes in the nucleus and with mature ribosomes in the cytoplasm has provided insights into the mechanisms with which different exosome-ribosome assemblies underpin opposite outcomes of RNA degradation: a constructive function of the nuclear exosome in the maturation of the large ribosomal subunit and a destructive function of the cytoplasmic exosome in the destruction of ribosome-bound mRNAs. Ongoing work is uncovering the unanticipated levels of regulation intrinsic to this multi-purpose degradation machinery. \nOur group has a long-standing interest in RNA metabolism\, with a particular focus on the molecular mechanisms of eukaryotic RNA transport and degradation. >more
URL:https://rna.umich.edu/events/elena-conti-max-planck-institute-of-biochemistry/
CATEGORIES:Seminar
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