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X-WR-CALDESC:Events for Center for RNA Biomedicine
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201202T160000
DTEND;TZID=America/Detroit:20201202T170000
DTSTAMP:20260420T111256
CREATED:20201014T173921Z
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SUMMARY:RNA Collaborative Seminar Series - University of California\, Santa Cruz hosting
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-university-of-california-santa-cruz-hosting/
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201203T120000
DTEND;TZID=America/Detroit:20201203T130000
DTSTAMP:20260420T111256
CREATED:20201124T185141Z
LAST-MODIFIED:20201124T185320Z
UID:7518-1606996800-1607000400@rna.umich.edu
SUMMARY:U-M Life Sciences Institute Seminar Series:Astrid D. Haase\, M.D.\, Ph.D.\, NIH
DESCRIPTION:“A small RNA perspective on genomic conflict”\nAstrid D. Haase\, M.D.\, Ph.D.\, Stadtman Tenure-Track Investigator\, National Institute of Diabetes and Digestive and Kidney Diseases\, National Institutes of Health \nHosted by: Vivian Cheung\, M.D. \nZOOM
URL:https://rna.umich.edu/events/u-m-life-sciences-institute-seminar-series/
CATEGORIES:External Talks
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201207T170000
DTEND;TZID=America/Detroit:20201207T180000
DTSTAMP:20260420T111256
CREATED:20200818T124310Z
LAST-MODIFIED:20201201T223204Z
UID:6372-1607360400-1607364000@rna.umich.edu
SUMMARY:RNA Innovation Seminar: John Mattick\, University of New South Wales\, Sydney\, Australia
DESCRIPTION:RNA at the epicenter of cell and developmental biology\n\nJohn Mattick\, Ph.D.\nProfessor of RNA Biology\nSchool of Biotechnology and Biomolecular Sciences\nUniversity of New South Wales\, Sydney\, Australia\n\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_fCIiMkveTdq3D9-PKFLm6Q \nFLYER IN PDF \nABSTRACT: The genomic programming of the development of complex organisms appears to have been misunderstood. The human genome contains just ~20\,000 protein-coding genes\, similar in number and with largely orthologous functions as those in other animals\, including simple nematodes with only 1\,000 somatic cells. By contrast\, the extent of non-protein-coding DNA increases with increasing developmental complexity\, reaching 98.8% in humans. Moreover\, it is now clear that the majority of the genome is not junk but is differentially and dynamically transcribed to produce not only mRNAs but also tens if not hundreds of thousands of short and long non-protein-coding RNAs that show specific expression patterns and subcellular locations. Many of these noncoding RNAs have evolved rapidly under positive selection for adaptive radiation\, and many have been shown to have important roles in development\, brain function\, cancer and other diseases. They function at many different levels of gene expression and cell biology\, including translational control\, formation of subcellular (phase-separated) domains\, and guidance of the epigenetic processes and chromatin dynamics that underpin development\, brain function and physiological adaptation\, with plasticity enabled by RNA editing\, RNA modification and retrotransposon mobilization. These discoveries mean that the assumption that combinatorial control by transcription factors and other regulatory proteins is sufficient to account for human ontogeny is incorrect\, as are the circular assumptions about the neutral evolution of the genome. The challenge now is to determine the structure-function relationships of these RNAs and their mechanisms of action\, as well as their place in the decisional hierarchies that control human development\, physiology\, learning and susceptibility to disorders
URL:https://rna.umich.edu/events/seminar-john-mattick/
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201214T160000
DTEND;TZID=America/Detroit:20201214T170000
DTSTAMP:20260420T111256
CREATED:20200818T125311Z
LAST-MODIFIED:20201202T175346Z
UID:6378-1607961600-1607965200@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Narry Kim\, Seoul National University
DESCRIPTION:“RNA-based regulation of viruses”\nNarry Kim\, PhD\nProfessor\, School of Biological Sciences\nSeoul National University\nFounding Director\, RNA Research Center\nInstitute for Basic Science\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_c9BFJM9dRGKn1WFF4L_wLg \nFLYER IN PDF \nAbstract: Viruses rely heavily on RNA binding proteins for their success as pathogens. In this presentation\, I will first talk about RNA tail modification which impacts viral and cellular gene expression. We found that TENT4 enzymes extend poly(A) tail of mRNAs with ‘mixed tails’ to delay deadenylation and stabilize the RNAs. Hepatitis B virus and human cytomegalovirus hijack this mechanism to efficiently stabilize their own RNAs. In the later part of my presentation\, I will discuss our recent work on SARS-CoV-2. To delineate the viral transcriptomic architecture and provide a high-resolution map of SARS-CoV-2\, we performed deep sequencing of infected cells. Our data define the canonical transcripts and noncanonical transcripts encoding unknown ORFs. More recently\, we have also performed proteomic analyses of the SARS-CoV-2 ribonucleoprotein complex. We identify many proteins that directly interact with viral RNAs and modulate viral growth. Functional investigation of the viral transcripts and host proteins discovered in this study will open new directions to the research efforts to elucidate the life cycle and pathogenicity of SARS-CoV-2. \n  \nBio: Narry Kim is a Professor in the School of Biological Sciences at Seoul National University and a founding director of RNA Research Center at Institute for Basic Science. She received her Ph.D. in 1998 from the University of Oxford where she studied lentiviruses and gene delivery. With keen interest in RNA biology\, she joined the Gideon Dreyfuss lab at the University of Pennsylvania and researched the role of the exon junction complex in mRNA surveillance. Her current research group investigates how genes are regulated at the RNA level\, with particular interests in microRNA\, mRNA\, and viral RNA. She is a recipient of the L’Oreal-UNESCO Women in Science Award\, Hoam Prize\, and Asan Prize\, and a member of KAS\, NAS and EMBO.
URL:https://rna.umich.edu/events/seminar-narry-kim-seoul-national-university/
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201216T090000
DTEND;TZID=America/Detroit:20201216T100000
DTSTAMP:20260420T111256
CREATED:20201014T174059Z
LAST-MODIFIED:20201014T174059Z
UID:7284-1608109200-1608112800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - European Molecular Biology Laboratory (EMBL) hosting
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-european-molecular-biology-laboratory-embl-hosting/
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