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X-WR-CALDESC:Events for Center for RNA Biomedicine
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DTSTART;TZID=America/Detroit:20201005T160000
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CREATED:20200825T212746Z
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SUMMARY:RNA Innovation Seminar: Chase Weidmann\, Washington University School of Medicine in St. Louis
DESCRIPTION:“Defining functional hubs in RNA-protein interaction networks”\n\nChase Weidmann\, Ph.D.\nPostdoctoral Research Scholar in the laboratory of Ben Major\nDepartment of Cell Biology & Physiology\, Washington University School of Medicine in St. Louis\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_y9HTFl5RSOSJTJ5qtlhVcw \nFLYER \nKeywords: mRNA regulation\, noncoding RNA\, RNA Structure\, RNP granules \nAbstract:\nChase Weidmann\, Ph.D. has contributed broadly to the field of RNA Biology during his career\, studying mechanisms of codon bias during translation\, post-transcriptional regulation of mRNAs by RNA-binding proteins\, the folding of long non-coding RNAs\, and how RNA-protein interaction networks contribute to the function and assembly of functional RNP particles. Chase developed a chemical probing strategy and next-gen sequencing technology\, called RNP-MaP\, that maps the location of and cooperation between multi-protein networks on RNAs in live cells. Going forward\, Chase is interested in understanding how alterations in RNA-binding protein profiles\, a cell’s “RBPome”\, confer deleterious activities onto noncoding RNAs in human disease\, especially in cancer. To further empower this work and his future research program\, Chase is now generating and integrating protein mass spectrometry data into his RBPome projects.
URL:https://rna.umich.edu/events/seminar-chase-weidmann-washington-university-school-of-medicine-in-st-louis/
LOCATION:MI
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201007T160000
DTEND;TZID=America/Detroit:20201007T170000
DTSTAMP:20260529T180416
CREATED:20201007T174627Z
LAST-MODIFIED:20201007T174627Z
UID:7216-1602086400-1602090000@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - The RNA Institute\, University at Albany hosting
DESCRIPTION:Hosted by: The RNA Institute\, University at Albany \nJoseph Wade\, Ph.D. “Pervasive translation in Mycobacterium tuberculosis”\nScott Tenenbaum\, Ph.D.\, “sxRNA: The Engineering of trans-Acting 3-Way Junctions for Function” \nModerator: Thomas Begely\, Ph.D. \n \nLink: https://albany.zoom.us/j/92165416119?pwd=WWFaa3c3TmVIaDlEM0pVcEs2bmxmZz09  \nRecording of the session\nFor more information\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-the-rna-institute-university-at-albany-hosting/
LOCATION:MI
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201019T160000
DTEND;TZID=America/Detroit:20201019T170000
DTSTAMP:20260529T180416
CREATED:20200818T123349Z
LAST-MODIFIED:20201005T115301Z
UID:6367-1603123200-1603126800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Gene Yeo\, University of California\, San Diego
DESCRIPTION:Systematic discovery of molecular and cellular functions of RNA binding proteins\nGene Yeo\, PhD\nProfessor\, Dept of Cellular and Molecular Medicine\, UCSD\nCo-Director\, UCSD Bioinformatics and Systems Biology Graduate Program\nUniversity of California\, San Diego\nInstitute for Genomic Medicine\nUCSD Stem Cell Program \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_CcI2trSATJy47aGtwrzhew \nFLYER IN PDF \nAbstract: The life-cycle of RNA from transcription to translational regulation is mediated by a diverse (>2000) set of proteins called RNA binding proteins. My lab studies the many roles that RNA binding proteins have in affecting RNA expression\, splicing\, transport and translation. Through our studies on RNA processing\, we have introduced therapeutic strategies to treat neurodegenerative and muscular diseases\, built cellular models of neurodevelopmental and neurodegenerative diseases and developed experimental and computational tools that enable the community to probe RNA binding protein-RNA interactions at scale. I will discuss (1) our established and new technologies to identify RNA targets of human RBPs at scale\, (2) systematic assays to assign molecular roles to RBPs and (2) functional screens to identify RBPs implicated in cancer / RNA granule formation.
URL:https://rna.umich.edu/events/seminar-gene-yeo-university-of-california-san-diego/
LOCATION:MI
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201021T160000
DTEND;TZID=America/Detroit:20201021T170000
DTSTAMP:20260529T180416
CREATED:20201007T175206Z
LAST-MODIFIED:20201014T173856Z
UID:7221-1603296000-1603299600@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - University of Pennsylvania RNA Group hosting
DESCRIPTION:Hosted by: University of Pennsylvania RNA Group \nKathy Fange Liu\, Ph.D.\n“RNA species dance to the beat of modifications” \nYoseph Barash\, Ph.D.\n“Splicing quantification from RNASeq – How to get the signal out of the noise?”\n \nModerator: Jeremy E Wilusz\, Ph.D. \nRecording of the session \nFor more information\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-university-of-pennsylvania-rna-group-hosting/
LOCATION:MI
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201026T090000
DTEND;TZID=America/Detroit:20201026T100000
DTSTAMP:20260529T180416
CREATED:20200818T122652Z
LAST-MODIFIED:20201022T131405Z
UID:6363-1603702800-1603706400@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Aleksandra Filipovska\, University of Western Australia
DESCRIPTION:Regulation of the mitochondrial transcriptome in health and disease\nAleksandra Filipovska\, Ph.D.\nProfessor\nThe University of Western Australia Centre for Medical Research\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_f8wC8rrJQzuhYzTEXoW69Q \nFLYER IN PDF \nAbstract:\nMitochondria produce more than 90% of the energy required by our bodies and thereby have a fundamental role in cell and energy metabolism. Mitochondria are composed of proteins encoded by both the nuclear and mitochondrial genomes and the coordinated expression of both genomes is essential for energy production. Impaired energy production leads to mitochondrial dysfunction that causes or contributes significantly to a variety of diseases including metabolic disorders and cardiovascular diseases. Mitochondrial dysfunction is caused by mutations in nuclear or mitochondrial genes that encode proteins or regulatory RNAs essential for mitochondrial biogenesis. How uncoordinated gene expression causes mitochondrial dysfunction and compromised energy production in heart and metabolic diseases is poorly understood\, making it difficult to develop effective treatments. To unravel how mitochondrial function fails and to identify therapeutic targets it is necessary (i) to understand how gene expression is regulated between mitochondria and the nucleus and (ii) how this regulation is disrupted in disease. We have created new and unique models of metabolic and cardiovascular diseases caused by mutations or loss of nuclear encoded RNA-binding proteins (RBPs) that regulate mitochondrial RNA metabolism and protein synthesis. These new models have identified that energy dysfunction can differentially affect specific organs such as the heart or liver\, or multiple organs leading to heart failure or metabolic diseases that can be devastating\, such as mitochondrial diseases\, or may be as common as insulin resistance and obesity. I will discuss the mechanisms behind these diverse pathologies caused by impaired gene expression and energy dysfunction in heart and metabolic disease. \nKeywords: mitochondria\, RNA\, ribosomes\, translation
URL:https://rna.umich.edu/events/seminar-aleksandra-filipovska-ph-d/
LOCATION:MI
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