Center for RNA Biomedicine

LSI Seminar: Blanton S. Tolbert, Ph.D., Case Western Reserve University
2021-02-04 12:00 - 13:00 (America/Detroit)
Structural biophysics of RNA interactions that contribute to viral replication
Blanton S. Tolbert, Ph.D.
Professor of Chemistry
Case Western Reserve University

LSI Seminar Series
Interests: Biochemistry, Biophysical Chemistry, Structural Biology
Blanton S. Tolbert is a professor of chemistry at Case Western Reserve University, where he oversees a diverse research group that endeavors to understand biochemical mechanisms by which human pathogenic RNA viruses replicate within cells, and to leverage this knowledge to identify novel drug targets for therapeutic intervention. Tolbert is the PI of multiple NIH grants, and he has published in top journals including Nature Communications, the Proceedings of the National Academy of Sciences and the Journal of the American Chemical Society. Tolbert also serves on the NIH Office of AIDS Research Advisory Council (OARAC), and he will become the next chair of OARAC in 2021. He is a member of the Burroughs Wellcome Fund Postdoctoral Enrichment Program Advisory Board and an editor for the Journal of Biological Chemistry and Microbiology and Molecular Biology Reviews. Tolbert is the proud father of two boys, and in his spare time he enjoys exploring the outdoors in the Cleveland Metroparks.

RNA Innovation Seminar: Jeff Twiss, University of South Carolina
2021-02-01 16:00 - 17:00 | Virtual
“Regulating the axonal proteome through mRNA transport and translation”

Jeffrey L. Twiss, M.D., Ph.D.
SmartState Chair in Childhood Neurotherapeutics
Professor of Biological Sciences
University of South Carolina

ZOOM
REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_Rss4i-7WTwyf8m8ogCPXEQ

FLYER IN PDF
Abstract: Neurons are extremely polarized cells with axonal and dendritic processes extending 100 to 1000 fold longer or more than the cell body diameter. Our lab has been interested in how axons grow to such great distances and how they respond to injury. mRNAs are transported into axons, with their localized translation providing the axon with autonomy to respond to different stimuli by modifying their local proteome. Transport, translation, and stability of axonal mRNAs is driven by interactions with RNA binding proteins and different signaling cascades. I will focus on recent work that gives insight into how specificity of these mechanisms is driven for different cohorts of axonal mRNAs.
Keywords: Neuron, Axon, RNA transport, Translational regulation

RNA Innovation Seminar: Elena Conti, Max Planck Institute of Biochemistry
2021-01-25 09:00 - 10:00
Talk title: The RNA exosome complex: the Dr Jekyll and Mr Hyde of RNA degradation
Elena Conti, PhD
Director, Max Planck Institute of Biochemistry

ZOOM
REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_IjnWw1UcRkW8zcDeuAM2tQ

Flyer in PDF
Keywords: molecular mechanisms, RNA, ribosome, biochemistry, cryo-EM, X-ray crystallography
Abstract: All RNAs in eukaryotic cells are eventually degraded. The RNA exosome is a conserved macromolecular machine that degrades a vast number and variety of RNAs. Exosome-mediated RNA degradation leads to the complete elimination of nuclear and cytoplasmic transcripts in turnover and quality control pathways, and to the partial trimming of RNA precursors in nuclear processing pathways. How the exosome combines specificity and versatility to either eliminate or process RNAs has been a long-standing question.
Over the years, our group has used biochemical and structural approaches to understand how the exosome core complex channels RNA substrates for degradation and how it associates with its nuclear and cytoplasmic cofactors. Visualizing how the exosome cofactors interact with pre-ribosomes in the nucleus and with mature ribosomes in the cytoplasm has provided insights into the mechanisms with which different exosome-ribosome assemblies underpin opposite outcomes of RNA degradation: a constructive function of the nuclear exosome in the maturation of the large ribosomal subunit and a destructive function of the cytoplasmic exosome in the destruction of ribosome-bound mRNAs. Ongoing work is uncovering the unanticipated levels of regulation intrinsic to this multi-purpose degradation machinery.
Our group has a long-standing interest in RNA metabolism, with a particular focus on the molecular mechanisms of eukaryotic RNA transport and degradation. >more

RNA Collaborative Seminar Series - NCI RNA Biology Initiative hosting
2021-01-13 16:00 - 17:00
For the seminar details, visit: https://www.rnasociety.org/rna-collaborative-seminar-series

RNA Collaborative Seminar Series - European Molecular Biology Laboratory (EMBL) hosting
2020-12-16 09:00 - 10:00

RNA Innovation Seminar: Narry Kim, Seoul National University
2020-12-14 16:00 - 17:00
“RNA-based regulation of viruses”
Narry Kim, PhD
Professor, School of Biological Sciences
Seoul National University
Founding Director, RNA Research Center
Institute for Basic Science

ZOOM
REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_c9BFJM9dRGKn1WFF4L_wLg
FLYER IN PDF
Abstract: Viruses rely heavily on RNA binding proteins for their success as pathogens. In this presentation, I will first talk about RNA tail modification which impacts viral and cellular gene expression. We found that TENT4 enzymes extend poly(A) tail of mRNAs with ‘mixed tails’ to delay deadenylation and stabilize the RNAs. Hepatitis B virus and human cytomegalovirus hijack this mechanism to efficiently stabilize their own RNAs. In the later part of my presentation, I will discuss our recent work on SARS-CoV-2. To delineate the viral transcriptomic architecture and provide a high-resolution map of SARS-CoV-2, we performed deep sequencing of infected cells. Our data define the canonical transcripts and noncanonical transcripts encoding unknown ORFs. More recently, we have also performed proteomic analyses of the SARS-CoV-2 ribonucleoprotein complex. We identify many proteins that directly interact with viral RNAs and modulate viral growth. Functional investigation of the viral transcripts and host proteins discovered in this study will open new directions to the research efforts to elucidate the life cycle and pathogenicity of SARS-CoV-2.

Bio: Narry Kim is a Professor in the School of Biological Sciences at Seoul National University and a founding director of RNA Research Center at Institute for Basic Science. She received her Ph.D. in 1998 from the University of Oxford where she studied lentiviruses and gene delivery. With keen interest in RNA biology, she joined the Gideon Dreyfuss lab at the University of Pennsylvania and researched the role of the exon junction complex in mRNA surveillance. Her current research group investigates how genes are regulated at the RNA level, with particular interests in microRNA, mRNA, and viral RNA. She is a recipient of the L’Oreal-UNESCO Women in Science Award, Hoam Prize, and Asan Prize, and a member of KAS, NAS and EMBO.

RNA Innovation Seminar: John Mattick, University of New South Wales, Sydney, Australia
2020-12-07 17:00 - 18:00
RNA at the epicenter of cell and developmental biology

John Mattick, Ph.D.
Professor of RNA Biology
School of Biotechnology and Biomolecular Sciences
University of New South Wales, Sydney, Australia

ZOOM
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FLYER IN PDF
ABSTRACT: The genomic programming of the development of complex organisms appears to have been misunderstood. The human genome contains just ~20,000 protein-coding genes, similar in number and with largely orthologous functions as those in other animals, including simple nematodes with only 1,000 somatic cells. By contrast, the extent of non-protein-coding DNA increases with increasing developmental complexity, reaching 98.8% in humans. Moreover, it is now clear that the majority of the genome is not junk but is differentially and dynamically transcribed to produce not only mRNAs but also tens if not hundreds of thousands of short and long non-protein-coding RNAs that show specific expression patterns and subcellular locations. Many of these noncoding RNAs have evolved rapidly under positive selection for adaptive radiation, and many have been shown to have important roles in development, brain function, cancer and other diseases. They function at many different levels of gene expression and cell biology, including translational control, formation of subcellular (phase-separated) domains, and guidance of the epigenetic processes and chromatin dynamics that underpin development, brain function and physiological adaptation, with plasticity enabled by RNA editing, RNA modification and retrotransposon mobilization. These discoveries mean that the assumption that combinatorial control by transcription factors and other regulatory proteins is sufficient to account for human ontogeny is incorrect, as are the circular assumptions about the neutral evolution of the genome. The challenge now is to determine the structure-function relationships of these RNAs and their mechanisms of action, as well as their place in the decisional hierarchies that control human development, physiology, learning and susceptibility to disorders

U-M Life Sciences Institute Seminar Series:Astrid D. Haase, M.D., Ph.D., NIH
2020-12-03 12:00 - 13:00
“A small RNA perspective on genomic conflict”
Astrid D. Haase, M.D., Ph.D., Stadtman Tenure-Track Investigator, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Hosted by: Vivian Cheung, M.D.
ZOOM

RNA Collaborative Seminar Series - University of California, Santa Cruz hosting
2020-12-02 16:00 - 17:00

RNA Collaborative Seminar Series - Harvard Medical School Initiative for RNA Medicine hosting
2020-11-18 16:00 - 17:00

RNA Innovation Seminar: Michelle Hastings, Rosalind Franklin University
2020-11-16 16:00 - 17:00
“Splice-switching Antisense Oligonucleotides for the Treatment of Disease”

Michelle Hastings, Ph.D.
Professor, Cell Biology and Anatomy; Director, Center for Genetic Diseases
Rosalind Franklin University of Medicine and Science

ZOOM
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Seminar flyer in PDF

ABSTRACT: Antisense oligonucleotides (ASOs) have proven to be an effective therapeutic platform for the treatment of disease. These short, single-stranded, modified nucleotides function by base-pairing with the complementary sequence of an RNA and modulating gene expression in a manner that is dependent on the ASO design and targeting site. We have used ASOs to normalize aberrant gene expression associated with a number of diseases of the nervous system including Alzheimer’s and Parkinson’s disease and Usher syndrome. One of our approaches is under development for the treatment of CLN3 Batten disease, a fatal, pediatric lysosomal storage disease caused by mutations in a gene encoding the lysosomal membrane protein CLN3. The most common mutation associated with CLN3 Batten is a deletion of exons 7 and 8 (CLN3Δex78), which disrupts the mRNA open reading frame by creating a premature termination codon that results in the production of a truncated protein. We devised a therapeutic strategy for treating CLN3 Batten Disease using an ASO that basepairs to CLN3 pre-mRNA and alters splicing to correct the open reading frame of the mutated transcript. Treatment of CLN3Δex78 neonatal mice by intracerebroventricular injection of the ASO resulted in the desired splicing effect throughout the central nervous system, improved motor deficits associated with the disease in mice, reduced histopathological features of the disease in the brain and extended life in a severe mouse model of the disease. Our results demonstrate that ASO-mediated reading frame correction is a promising therapeutic approach for CLN3 Batten disease.
KEYWORDS: pre-mRNA splicing, Antisense oligonucleotides, Usher syndrome, Batten Disease, lysosomal storage diseases

RNA Collaborative Seminar Series - University of Rochester Center for RNA Biology hosting
2020-11-04 16:00 - 17:00

RNA Innovation Seminar: Aleksandra Filipovska, University of Western Australia
2020-10-26 09:00 - 10:00
Regulation of the mitochondrial transcriptome in health and disease
Aleksandra Filipovska, Ph.D.
Professor
The University of Western Australia Centre for Medical Research

ZOOM
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FLYER IN PDF
Abstract:
Mitochondria produce more than 90% of the energy required by our bodies and thereby have a fundamental role in cell and energy metabolism. Mitochondria are composed of proteins encoded by both the nuclear and mitochondrial genomes and the coordinated expression of both genomes is essential for energy production. Impaired energy production leads to mitochondrial dysfunction that causes or contributes significantly to a variety of diseases including metabolic disorders and cardiovascular diseases. Mitochondrial dysfunction is caused by mutations in nuclear or mitochondrial genes that encode proteins or regulatory RNAs essential for mitochondrial biogenesis. How uncoordinated gene expression causes mitochondrial dysfunction and compromised energy production in heart and metabolic diseases is poorly understood, making it difficult to develop effective treatments. To unravel how mitochondrial function fails and to identify therapeutic targets it is necessary (i) to understand how gene expression is regulated between mitochondria and the nucleus and (ii) how this regulation is disrupted in disease. We have created new and unique models of metabolic and cardiovascular diseases caused by mutations or loss of nuclear encoded RNA-binding proteins (RBPs) that regulate mitochondrial RNA metabolism and protein synthesis. These new models have identified that energy dysfunction can differentially affect specific organs such as the heart or liver, or multiple organs leading to heart failure or metabolic diseases that can be devastating, such as mitochondrial diseases, or may be as common as insulin resistance and obesity. I will discuss the mechanisms behind these diverse pathologies caused by impaired gene expression and energy dysfunction in heart and metabolic disease.
Keywords: mitochondria, RNA, ribosomes, translation

RNA Collaborative Seminar Series - University of Pennsylvania RNA Group hosting
2020-10-21 16:00 - 17:00
Hosted by: University of Pennsylvania RNA Group
Kathy Fange Liu, Ph.D.
“RNA species dance to the beat of modifications”
Yoseph Barash, Ph.D.
“Splicing quantification from RNASeq – How to get the signal out of the noise?”

Moderator: Jeremy E Wilusz, Ph.D.
Recording of the session
For more information, visit: https://www.rnasociety.org/rna-collaborative-seminar-series

RNA Innovation Seminar: Gene Yeo, University of California, San Diego
2020-10-19 16:00 - 17:00
Systematic discovery of molecular and cellular functions of RNA binding proteins
Gene Yeo, PhD
Professor, Dept of Cellular and Molecular Medicine, UCSD
Co-Director, UCSD Bioinformatics and Systems Biology Graduate Program
University of California, San Diego
Institute for Genomic Medicine
UCSD Stem Cell Program
ZOOM
REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_CcI2trSATJy47aGtwrzhew
FLYER IN PDF
Abstract: The life-cycle of RNA from transcription to translational regulation is mediated by a diverse (>2000) set of proteins called RNA binding proteins. My lab studies the many roles that RNA binding proteins have in affecting RNA expression, splicing, transport and translation. Through our studies on RNA processing, we have introduced therapeutic strategies to treat neurodegenerative and muscular diseases, built cellular models of neurodevelopmental and neurodegenerative diseases and developed experimental and computational tools that enable the community to probe RNA binding protein-RNA interactions at scale. I will discuss (1) our established and new technologies to identify RNA targets of human RBPs at scale, (2) systematic assays to assign molecular roles to RBPs and (2) functional screens to identify RBPs implicated in cancer / RNA granule formation.

RNA Collaborative Seminar Series - The RNA Institute, University at Albany hosting
2020-10-07 16:00 - 17:00
Hosted by: The RNA Institute, University at Albany
Joseph Wade, Ph.D. “Pervasive translation in Mycobacterium tuberculosis”
Scott Tenenbaum, Ph.D., “sxRNA: The Engineering of trans-Acting 3-Way Junctions for Function”
Moderator: Thomas Begely, Ph.D.

Link: https://albany.zoom.us/j/92165416119?pwd=[REDACTED]
Recording of the session
For more information, visit: https://www.rnasociety.org/rna-collaborative-seminar-series

RNA Innovation Seminar: Chase Weidmann, Washington University School of Medicine in St. Louis
2020-10-05 16:00 - 17:00
“Defining functional hubs in RNA-protein interaction networks”

Chase Weidmann, Ph.D.
Postdoctoral Research Scholar in the laboratory of Ben Major
Department of Cell Biology & Physiology, Washington University School of Medicine in St. Louis

ZOOM
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FLYER
Keywords: mRNA regulation, noncoding RNA, RNA Structure, RNP granules
Abstract:
Chase Weidmann, Ph.D. has contributed broadly to the field of RNA Biology during his career, studying mechanisms of codon bias during translation, post-transcriptional regulation of mRNAs by RNA-binding proteins, the folding of long non-coding RNAs, and how RNA-protein interaction networks contribute to the function and assembly of functional RNP particles. Chase developed a chemical probing strategy and next-gen sequencing technology, called RNP-MaP, that maps the location of and cooperation between multi-protein networks on RNAs in live cells. Going forward, Chase is interested in understanding how alterations in RNA-binding protein profiles, a cell’s “RBPome”, confer deleterious activities onto noncoding RNAs in human disease, especially in cancer. To further empower this work and his future research program, Chase is now generating and integrating protein mass spectrometry data into his RBPome projects.

William EM Lands lecture featuring Jean Schaffer, MD, PhD, Joslin Diabetes Center, Harvard Medical School
2020-09-29 12:00 - 13:00
snoRNAs: Novel Links to Metabolism

Jean Schaffer, MD, PhD
Associate Research Director
Joslin Diabetes Center, Harvard Medical School
flyer

Department of Biological Chemistry, William EM Lands lecture

RNA Innovation Seminar: Hiroaki Suga, University of Tokyo
2020-09-28 09:00 - 10:00
“Genetic code reprogramming that Revolutionizes the discovery processes of peptide drug leads”

Hiroaki Suga, PhD
Professor, Department of Chemistry, Graduate School of Science
The University of Tokyo, Japan

ZOOM
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ABSTRACT: Macrocyclic peptides possess a number of pharmacological characteristics distinct from other well-established therapeutic molecular classes, resulting in a versatile drug modality with a unique profile of advantages. Macrocyclic peptides are accessible by not only chemical synthesis but also ribosomal synthesis. Particularly, recent inventions of the genetic code reprogramming integrated with an in vitro display format, referred to as RaPID (Random non-standard Peptides Integrated Discovery) system, have enabled us to screen mass libraries (>1 trillion members) of non-standard peptides containing multiple non-proteinogenic amino acids, giving unique properties of peptides distinct from conventional peptides, e.g. greater proteolytic stability, higher affinity (low nM to sub nM dissociation constants similar to antibodies), and superior pharmacokinetics. The field is rapidly growing evidenced by increasing interests from industrial sectors, including small start-ups as well as mega-pharmas, toward drug development efforts on macrocyclic peptides, which has led to several de novo discovered peptides entering clinical trials. This lecture discusses the aforementioned screening technology involving the method of “genetic code reprogramming” powered by flexizymes, and several showcases of therapeutic potentials of macrocyclic peptides
Join us for a Journal club to prepare for Dr Suga’s seminar
September 24 @ 4:00 pm – 5:00 pm
ZOOM LINK: https://umich.zoom.us/j/93910966695
Publication to review:“Ribosomal Formation of Thioamide Bonds in Polypeptide Synthesis” Rumit Maini, Hiroyuki Kimura, Ryo Takatsuji, Takayuki Katoh, Yuki Goto, and Hiroaki Suga https://pubs.acs.org/doi/pdf/10.1021/jacs.9b11097
RESEARCH INTERESTS: In the Suga lab, our aim is to utilize organic chemistry techniques in combination with biology to tackle yet unresolved questions. In our inclusive research, we procure scientific knowledge leading to new concepts and develop novel technologies with broad applicability, which can extend to drug discovery. We provide a diligent and cooperative research environment with a goal of nurturing individuals so they are brimming with innovation and global-mindedness.

RiboClub Forum
2020-09-23 08:00 - 2020-09-25 17:00 | Virtual
RiboClub FORUM
RNA Biology and Technology – The Current Pandemic and Beyond

Over 35 RNA scientists from Canada, the US and Europe, come together in this two-day forum.
Abstract submission deadline: August 1st
Registration deadline: September 1st

MORE INFO

RNA Innovation Seminar: Andrey S. Krasilnikov, PhD, Penn State University
2020-09-21 16:00 - 17:00 | Virtual
“Structures of eukaryotic RNases MRP/P RNPs reveal RNA-driven protein remodeling”
Andrey Krasilnikov, Associate Professor of Biochemistry and Molecular Biology, Center for RNA Biology, Pennsylvania State University

Keywords: Ribozymes, RNase P, RNase MRP, ribonucleoprotein complexes, RNA-driven protein remodelling
ZOOM
REGISTRATION REQUIRED:
https://umich.zoom.us/webinar/register/WN_obckKUCLT4mXI7kPskzc-Q

Abstract: Ribonuclease (RNase) P is a ribozyme-based catalytic ribonucleoprotein complex involved primarily in the maturation of tRNA in all three domains of life. In the course of evolution, the size and complexity of RNase P grew as the catalytic RNA moiety recruited additional protein components. In eukaryotes, the RNase P lineage has split, giving rise to a related RNP enzyme called RNase MRP, which shares multiple structural features (including most of the protein components) with the eukaryotic RNase P, but has a distinct and non-overlapping specificity.
We report the recently solved cryo-EM structure of the 450 kDa yeast RNase MRP holoenzyme and compare it with the structure of its progenitor RNP, RNase P. We show that, surprisingly, several of the proteins shared by RNase MRP and RNase P undergo RNA-driven structural remodeling, allowing the same proteins to function in distinct structural contexts. This remodeling, combined with altered peripheral RNA elements, results in the functional diversification of the two closely related RNPs, in spite of the structural conservation of the nearly identical catalytic cores, demonstrating structural underpinnings of the acquisition of new functions by catalytic RNPs.

RNA Collaborative Seminar Series - U-M Center for RNA Biomedicine hosting
2020-09-09 16:00 - 17:00
Wednesday, September 9, 2020, 4:00–5:00 pm ET

Hosted by: U-MCenter for RNA Biomedicine

We will hear from:

Sue Hammoud, Ph.D.
Assistant Professor of Human Genetics
“Same Same Different: Single cell RNAseq identifies conserved and divergent features of mammalian spermatogenesis”

~and~

Justin Colacino, Ph.D.
Assistant Professor of Environmental Health Sciences
“Single cell transcriptomic profiling to understand breast stem cell heterogeneity in development and cancer disparities”

ZOOM registration link

Recording of the session

The RNA Collaborative seminar series goal is to cross-promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; NCI RNA Biology Initiative; RiboClub Sherbrooke; The RNA Institute, University At Albany; UMass Medical School, RNA Therapeutics Institute; University of Michigan Center for RNA Biomedicine; University of Rochester Center for RNA Biology; Yale Center for RNA Science and Medicine, European Molecular Biology Laboratory (EMBL), Shanghai RNA Club, The Bay Area RNA Club (BARC), UCSC Center for Molecular Biology of RNA, and NUS-CSI Singapore RNA Biology Center, Penn RNA Group, University of Pennsylvania, and Helmholtz Institute for RNA-based Infection Research.

RNA Collaborative

RNA Collaborative Seminar Series - Yale Center for RNA Science and Medicine hosting
2020-08-26 16:00 - 17:00
Wednesday, August 26, 2020, 4:00–5:00 pm

Hosted by Yale Center for RNA Science and Medicine

Siyuan (Steven) Wang, Ph.D. “Image-based spatial genomics and transcriptomics”
Junjie Guo, Ph.D. “RNA decay deficits cause neurodegeneration in ALS/FTD”

ZOOM link

Recording of the session

The RNA Collaborative seminar series goal is to cross promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; NCI RNA Biology Initiative; RiboClub Sherbrooke; The RNA Institute, University At Albany; UMass Medical School, RNA Therapeutics Institute; University of Michigan Center for RNA Biomedicine; University of Rochester Center for RNA Biology; Yale Center for RNA Science and Medicine, European Molecular Biology Laboratory (EMBL), Shanghai RNA Club, The Bay Area RNA Club (BARC), UCSC Center for Molecular Biology of RNA, and NUS-CSI Singapore RNA Biology Center.

RNA Collaborative Seminar Series - NIH NCI RNA Biology Initiative hosting
2020-08-12 16:00 - 17:00
Wednesday, August 12, 2020, 4:00–5:00 pm

Hosted by NCI RNA Biology Initiative

Shuo Gu, Ph.D. “A tale of tails: How 3’ uridylation alters miRNA function”
Voula Mili, Ph.D. “Local co-translational interactions control protein function”

Recording of the session

The RNA Collaborative seminar series goal is to cross promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; NCI RNA Biology Initiative; RiboClub Sherbrooke, Québec; The RNA Institute, University At Albany; UMass Medical School, RNA Therapeutics Institute; University of Michigan Center for RNA Biomedicine;University of Rochester Center for RNA Biology; Yale Center for RNA Science and Medicine

RNA Collaborative Seminar Series - Harvard Medical School Initiative for RNA Medicine hosting
2020-07-29 17:00
Wednesday, July 29, 2020, 4:00–5:00 pm

Hosted by Harvard Medical School Initiative for RNA Medicine

Tim Yu, MD, PhD. “Prospects for hyper-individualized RNA medicines”
Shobha Vasudevan, Ph.D. “A specialized post-transcriptional program in chemoresistant, quiescent cancer cells”
Moderator: Frank Slack, Ph.D.

Recording of the session
Upcoming seminars are available on the RNA Society’s new page: RNA Collaborative

The RNA Collaborative seminar series goal is to cross promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; RiboClub Sherbrooke, Québec;The RNA Institute, University At Albany;UMass Medical School, RNA Therapeutics Institute;University of Michigan Center for RNA Biomedicine;University of Rochester Center for RNA Biology;Yale Center for RNA Science and Medicine

RNA Collaborative Seminar Series - University of Rochester Center for RNA Biology
2020-07-15 16:00 - 17:00
Wednesday, July 15, 2020, 4:00–5:00 pm

Hosted by University of Rochester Center for RNA Biology
“Programmable RNA-targeting by CRISPR-Cas enzymes”
Mitch O’Connell, Ph.D., Assistant Professor, Department of Biochemistry & Biophysics; Member, Center for RNA Biology
“Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs”
Xin Li, Ph.D., Associate Professor, Departments of Biochemistry & Biophysics, and Urology; Member, Center for RNA Biology

Moderator: Lynne Maquat, PhD

Recording of the session
Upcoming seminars are available on the RNA Society’s new page: RNA Collaborative

The RNA Collaborative seminar series goal is to cross promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; NCI RNA Biology Initiative; RiboClub Sherbrooke, Québec; The RNA Institute, University At Albany; UMass Medical School, RNA Therapeutics Institute; University of Michigan Center for RNA Biomedicine;University of Rochester Center for RNA Biology; Yale Center for RNA Science and Medicine

Seminar: Kate A. Fitzgerald, UMass Medical School - lnc’ing RNA to Innate Immunity
2020-07-13 16:00 - 17:00 | Virtual
lnc’ing RNA to Innate Immunity
Kate A. Fitzgerald, Professor of Medicine
Vice Chair, Research, Department of Medicine,
Director, Program in Innate Immunity
Worcester Foundation Chair in Biomedical Sciences
Department of Medicine
University of Massachusetts Medical School
Keywords: lncRNA, Innate Immunity, Interferon, Antiviral
ZOOM REGISTRATION REQUIRED

RNA Collaborative Seminar Series - MD Anderson Center for RNA Interference and Non-Coding RNAs hosting
2020-07-01 16:00 - 17:00
Wednesday, July 1, 2020, 4:00–5:00 pm

Hosted by MD Anderson Center for RNA Interference and Non-Coding RNAs

“ncRNAs: ‘inside out’ cancer regulomers”
Simone Anfossi, Instructor and Fellow of the MDACC ncRNA Center

“Therapeutic Targeting of ncRNAs in Cancer”
Cristian Rodriguez-Aguayo, Instructor and Fellow of the MDACC ncRNA Center

Moderator: George Calin

Recording of the session
The RNA Collaborative seminar series goal is to cross promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; NCI RNA Biology Initiative; RiboClub Sherbrooke, Québec; The RNA Institute, University At Albany; UMass Medical School, RNA Therapeutics Institute; University of Michigan Center for RNA Biomedicine;University of Rochester Center for RNA Biology; Yale Center for RNA Science and Medicine

RNA Collaborative Seminar Series - UMass Medical School, RNA Therapeutics Institute
2020-06-17 16:00 - 17:00
Wednesday, June 17, 2020, 4:00–5:00 pm

Hosted by UMass Medical School, RNA Therapeutics Institute
Athma Pai
“How efficiently do cells create mRNA? Balancing speed and accuracy in gene regulation”

Jonathan Watts
“Fighting fire with fire (or RNA with RNA) in the treatment of COVID-19”

Moderator: Phil Zamore, PhD

Registration

Recording of the session

The RNA Collaborative seminar series goal is to cross promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; NCI RNA Biology Initiative; RiboClub Sherbrooke, Québec; The RNA Institute, University At Albany; UMass Medical School, RNA Therapeutics Institute; University of Michigan Center for RNA Biomedicine;University of Rochester Center for RNA Biology; Yale Center for RNA Science and Medicine

RNA Collaborative Seminar Series - Sherbrooke, Québec hosting
2020-06-03 16:00 - 17:00
Wednesday, June 3, 2020, 4:00–5:00 pm

Hosted by the Riboclub, Sherbrooke, Québec

Nutrient-dependent control of RNA polymerase II elongation rate regulates gene expression programs by alternative polyadenylation
Francois Bachand, Sherbrooke

Spliceosome Structure: Can the Blind Men Now Describe the Elephant?
Andrew McMillan, University of Alberta

Moderator: Sherif Abou Elela

For the ZOOM link, please email leandro.fequino@usherbrooke.ca

Recording of the session

The RNA Collaborative seminar series goal is to cross promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; NCI RNA Biology Initiative; RiboClub Sherbrooke, Québec; The RNA Institute, University At Albany; UMass Medical School, RNA Therapeutics Institute; University of Michigan Center for RNA Biomedicine;University of Rochester Center for RNA Biology; Yale Center for RNA Science and Medicine
