BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Center for RNA Biomedicine - ECPv6.16.2//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Center for RNA Biomedicine X-ORIGINAL-URL:https://rna.umich.edu X-WR-CALDESC:Events for Center for RNA Biomedicine REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/Detroit BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20200308T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20201101T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20210314T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20211107T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20220313T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20221106T060000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211220T160000 DTEND;TZID=America/Detroit:20211220T170000 DTSTAMP:20260526T191738 CREATED:20210827T134635Z LAST-MODIFIED:20211210T212954Z UID:9277-1640016000-1640019600@rna.umich.edu SUMMARY:RNA Faculty Candidate Seminar: Dr. Alisha 'Jonesy' Jones\, Institute of Structural Biology\, Helmholtz Zentrum Munich DESCRIPTION:“Modulation of the MALT1 pre-mRNA structure by hnRNP proteins regulates T cell activation”\nDr. Alisha ‘Jonesy’ Jones\nPostdoctoral Researcher\nInstitute of Structural Biology\nHelmholtz Zentrum Munich \n  \n  \nFlyer in PDF \nCo-Hosts: The Center for RNA Biomedicine\, Department of Biological Chemistry\, and the Program in Biophysics \nHybrid Seminar:\nIn-person: Biomedical Science Research Buliding (BSRB)\, ABC Seminar rooms\nZoom: https://umich.zoom.us/webinar/register/WN_3yrQ47UuTKKuzigbe38Sww \nKeywords: pre-mRNA\, hnRNP\, NMR\, SHAPE\, structure \nAbstract: Alternative splicing is controlled by differential binding of trans-acting RNA binding proteins (RBPs) to cis-regulatory pre-mRNA elements. How pre-mRNA secondary structure affects recognition by RBPs and determines alternative exon usage is poorly understood. The MALT1 paracaspase is a key component of signaling pathways that mediate innate and adaptive immune responses. Alternative splicing of MALT1 exon7 is critical for controlling optimal T cell activation. Here\, we demonstrate that MALT1 pre-mRNA splicing depends on RNA structural elements that shield the splice sites of the alternatively spliced exon7. The RBPs hnRNP U and hnRNP L bind comparably and competitively to identical stem-loop RNA structures flanking the 5’ and 3’ splice sites of MALT1 exon7. While hnRNP U stabilizes RNA stem-loop conformations that maintain exon7 skipping\, hnRNP L destabilizes these RNA elements to facilitate recruitment of the essential splicing factor U2AF2 to promote exon7 inclusion. This work represents a paradigm for the control of splice site selection by differential RBP binding and modulation of pre-mRNA structure. \nIn-person event COVID guidelines URL:https://rna.umich.edu/events/alisha-jonesy-jones/ CATEGORIES:Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211215T160000 DTEND;TZID=America/Detroit:20211215T170000 DTSTAMP:20260526T191738 CREATED:20210901T192352Z LAST-MODIFIED:20210901T192352Z UID:9335-1639584000-1639587600@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: Harvard Medical School Initiative for RNA Medicine DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-harvard-medical-school-initiative-for-rna-medicine/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211213T160000 DTEND;TZID=America/Detroit:20211213T170000 DTSTAMP:20260526T191738 CREATED:20210827T134607Z LAST-MODIFIED:20211210T172017Z UID:9275-1639411200-1639414800@rna.umich.edu SUMMARY:RNA Faculty Candidate Seminar: Paul Donlin-Asp\, Max Planck Institute for Brain Research DESCRIPTION:“Resolving the localisation and dynamics of mRNA and protein synthesis within neurons”\nPaul Donlin-Asp\, Ph.D.\nPostdoctoral Researcher\nDepartment of Synaptic Plasticity\nMax Planck Institute for Brain Research \n  \n  \n  \n  \nFlyer in PDF \nCo-Host: The Department of Molecular\, Cellular\, and Developmental Biology \nHybrid Seminar:\nIn-person: Biomedical Science Research Building (BSRB)\, ABC Seminar rooms\nZoom: https://umich.zoom.us/webinar/register/WN_tZjYxppSQwaDVTYIuC0jkw \nKeywords: mRNA dynamics\, local protein synthesis\, neurons\, neuronal cell biology\, synaptic plasticity\, in vivo imaging \nIn-person event COVID guidelines URL:https://rna.umich.edu/events/donlin-asp/ CATEGORIES:Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211207T120000 DTEND;TZID=America/Detroit:20211207T130000 DTSTAMP:20260526T191738 CREATED:20210901T190413Z LAST-MODIFIED:20210901T190413Z UID:9311-1638878400-1638882000@rna.umich.edu SUMMARY:Chase Beisel\, Helmholtz Center for infection Research DESCRIPTION:“Multiplexable RNA Detection by Cas9 Paves the Way for Novel COVID Testing Method”\nChase Beisel\, Helmholtz Center for infection Research\nDepartment of Biological Chemistry seminar\nLocation: 3330 MS I\nHosts: Yan Zhang and Nils Walter URL:https://rna.umich.edu/events/chase-beisel-helmholtz-center-for-infection-research/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211201T160000 DTEND;TZID=America/Detroit:20211201T170000 DTSTAMP:20260526T191738 CREATED:20210901T192308Z LAST-MODIFIED:20210901T192308Z UID:9333-1638374400-1638378000@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: Penn RNA Group - University of Pennsylvania DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-penn-rna-group-university-of-pennsylvania/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211117T160000 DTEND;TZID=America/Detroit:20211117T170000 DTSTAMP:20260526T191738 CREATED:20210901T192222Z LAST-MODIFIED:20210901T192222Z UID:9331-1637164800-1637168400@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: The RNA Institute\, University At Albany DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-the-rna-institute-university-at-albany/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211109T120000 DTEND;TZID=America/Detroit:20211109T130000 DTSTAMP:20260526T191738 CREATED:20210901T185606Z LAST-MODIFIED:20210908T170232Z UID:9302-1636459200-1636462800@rna.umich.edu SUMMARY:BiolChem Seminar: Ailong Ke\, Cornell University DESCRIPTION:“Structural Basis of Bacterial CRISPR Immunity”\nAilong Ke\, Cornell University\nDepartment of Biological Chemistry seminar\nLocation: 3330 MS I\nHosts: Yan Zhang and Nils Walter URL:https://rna.umich.edu/events/ailong-ke/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211108T160000 DTEND;TZID=America/Detroit:20211108T170000 DTSTAMP:20260526T191738 CREATED:20210827T134511Z LAST-MODIFIED:20211025T164624Z UID:9271-1636387200-1636390800@rna.umich.edu SUMMARY:RNA Innovation Seminar: Zhonggang Hou & Jun Hee Lee DESCRIPTION:“Harnessing diverse compact CRISPR-Cas3 for long-range genome engineering”\nZhonggang Hou\, Ph.D.\nResearch Investigator\nBiological Chemistry \nABSTRACT: Leading CRISPR-Cas technologies employ Cas9 and Cas12 enzymes that generate RNA-guided dsDNA breaks. Yet\, the most abundant microbial adaptive immune systems\, Type I CRISPR\, is under-exploited for eukaryotic application. I will discuss our effort on adopting the first minimal CRISPR-Cas3 from Neisseria Type I-C system\, to create targeted large chromosomal deletions in human cells. RNP delivery of the processive Cas3 nuclease and target recognition complex Cascade\, gave up to 90% editing efficiency. Unexpectedly\, Type I-C Cascade assembly in bacteria requires a previous unknown internal translation product Cas11 from within the cas8 gene. Our data show that expression of a separately encoded Cas11 is the key to enable plasmid- and mRNA- based editing in human cells. We demonstrate that “supplying cas11” is a universal strategy to harness divergent and streamlined Type I-C\, I-D and I-B editors with distinct PAM preferences and guide orthogonality. Our findings expand the CRISPR toolbox for long-range genome engineering. \nKEYWORDS: CRISPR; genome editing; Cascade; Cas3; Cas11; DNA targeting; crRNA; large deletion; Neisseria; genome engineering \n  \n  \n“Microscopic Examination of Spatial Transcriptome through Seq-Scope”\nJun Hee Lee\, Ph.D.\nAssociate Professor\nMolecular & Integrative Physiology \nKEYWORDS: Spatial Transcriptomics\, Seq-Scope \n  \nRegistration: https://umich.zoom.us/webinar/register/WN_qBK6mw7vQa6jOkZuS81_VQ \nFLYER IN PDF URL:https://rna.umich.edu/events/zhonggang-hou-and-jun-hee-lee/ CATEGORIES:Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211103T160000 DTEND;TZID=America/Detroit:20211103T170000 DTSTAMP:20260526T191738 CREATED:20210901T192135Z LAST-MODIFIED:20210901T192135Z UID:9329-1635955200-1635958800@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: UCSC Center for Molecular Biology of RNA DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-ucsc-center-for-molecular-biology-of-rna/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211026T120000 DTEND;TZID=America/Detroit:20211026T130000 DTSTAMP:20260526T191738 CREATED:20210901T185327Z LAST-MODIFIED:20210908T170049Z UID:9297-1635249600-1635253200@rna.umich.edu SUMMARY:BiolChem Seminar: Michael Terns\, University of Georgia DESCRIPTION:“Know Thy Enemy: Making CRISPR Memories”\nMichael Terns\, University of Georgia\nDepartment of Biological Chemistry seminar\nLocation: 3330 MS I\nHosts: Yan Zhang and Nils Walter URL:https://rna.umich.edu/events/michael-terns/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211020T090000 DTEND;TZID=America/Detroit:20211020T100000 DTSTAMP:20260526T191738 CREATED:20210901T192024Z LAST-MODIFIED:20210901T192024Z UID:9327-1634720400-1634724000@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: Helmholtz Institute for RNA-based Infection Research DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-helmholtz-institute-for-rna-based-infection-research/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211018T160000 DTEND;TZID=America/Detroit:20211018T170000 DTSTAMP:20260526T191738 CREATED:20210827T134441Z LAST-MODIFIED:20210930T165005Z UID:9269-1634572800-1634576400@rna.umich.edu SUMMARY:RNA Innovation Seminar: Tim Stasevich\, Ph.D. DESCRIPTION:“Imaging single-mRNA translation dynamics in living color”\nTim Stasevich\, Ph.D.\nAssociate Professor\nDean and Pingping Tsao Professor of Biochemistry\nCSU Monfort Professor\nBoettcher Investigator\nColorado State University \nRegistration: https://umich.zoom.us/webinar/register/WN_OzTuwf2zRN-6zCZk1pA_lQ \n  \nFlyer in PDF \nKeywords:\ntranslational regulation\, gene expression\, fluorescence microscopy\, intrabodies\, single-molecule imaging \nAbstract:\nMy lab is creating technology to image mRNA translation in real time and with single-molecule precision in living cells. In this talk\, I will introduce our technology and describe how it can be used to amplify fluorescence from newly synthesized proteins as they are being translated from single mRNAs. I will show how we quantify these signals to determine the size\, shape\, subcellular localization\, and mobilities of mRNA translation sites\, as well as their protein synthesis dynamics. I will then highlight a few recent applications of our technology\, focusing mainly on a new biosensor we have developed to quantify how individual regulatory factors impact single mRNA translation dynamics. Using this biosensor\, we provide evidence that human Argonaute2 (Ago2) shuts down translation by down regulating translation initiation on the minutes timescale and helping usher translationally silent mRNAs into P-bodies on the hours timescale. I will conclude by discussing new fluorescent intrabodies my lab is engineering to light up nascent and mature proteins in multiple colors. As these intrabodies can be encoded on plasmids\, they can easily be adapted by other labs to image gene activity in diverse living systems. \nTimothy J. Stasevich is an Associate Professor in the Department of Biochemistry and Molecular Biology at Colorado State University (CSU). His lab uses a combination of advanced fluorescence microscopy\, genetic engineering\, and computational modeling to study the dynamics of gene regulation in living mammalian cells. His lab helped pioneer the imaging of real-time single-mRNA translation dynamics in living cells1. Dr. Stasevich received his B.S. in Physics and Mathematics from the University of Michigan\, Dearborn\, and his Ph. D. in Physics from the University of Maryland\, College Park. He transitioned into experimental biophysics as a post-doctoral research fellow in the laboratory of Dr. James G. McNally at the National Cancer Institute. During this time\, he developed technology based on fluorescence microscopy to help establish gold-standard measurements of live-cell protein dynamics. Dr. Stasevich next moved to Osaka University\, where he worked with Dr. Hiroshi Kimura as a Japan Society for the Promotion of Science Foreign Postdoctoral Research Fellow. While there\, he helped create technology to image endogenous proteins and their post-translation modifications in vivo. This allowed him to image the live-cell dynamics of epigenetic histone modifications during gene activation for the first time2. Before joining the faculty at CSU\, Dr. Stasevich spent a year as a Visiting Fellow at the HHMI Janelia Research Campus\, where he applied superresolution fluorescence microscopy to improve the spatiotemporal resolution of endogenous protein imaging in live cells. \n1. Morisaki\, T. et al. Real-time quantification of single RNA translation dynamics in living cells. Science 352\, 1425–1429 (2016).\n2. Stasevich\, T. J. et al. Regulation of RNA polymerase II activation by histone acetylation in single living cells. Nature 516\, 272–275 (2014). URL:https://rna.umich.edu/events/tim-stasevich/ CATEGORIES:Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211012T120000 DTEND;TZID=America/Detroit:20211012T130000 DTSTAMP:20260526T191738 CREATED:20210901T185022Z LAST-MODIFIED:20210908T170009Z UID:9294-1634040000-1634043600@rna.umich.edu SUMMARY:BiolChem Seminar: Sam Sternberg\, Columbia University DESCRIPTION:“Functional Interplay Between CRISPR-Cas and Transposable Elements”\nSam Sternberg\, Columbia University\nDepartment of Biological Chemistry seminar\nLocation: 3330 MS I\nHosts: Yan Zhang and Nils Walter URL:https://rna.umich.edu/events/sam-sternberg/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211006T090000 DTEND;TZID=America/Detroit:20211006T100000 DTSTAMP:20260526T191738 CREATED:20210901T191902Z LAST-MODIFIED:20210901T191902Z UID:9325-1633510800-1633514400@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: NUS-CSI Singapore RNA Biology Center DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-nus-csi-singapore-rna-biology-center/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211005T150000 DTEND;TZID=America/Detroit:20211005T160000 DTSTAMP:20260526T191738 CREATED:20210901T193912Z LAST-MODIFIED:20210929T155531Z UID:9346-1633446000-1633449600@rna.umich.edu SUMMARY:Human Genetics Seminar: Rajesh Rao\, Ophthalmology & Visual Science\, U-M Medical School DESCRIPTION:“Genetics through the Lens of an Ophthalmologist and Vision Scientist”\nRajesh C. Rao\, M.D.\nLeonard G. Miller Professor\nAssociate Professor\nDepartment of Ophthalmology & Visual Sciences\nDepartment of Pathology \n  \nDepartment of Human Genetics seminar\nZOOM MEETING ID: 947 5800 7294\nPASSCODE: 900076\nhttps://umich.zoom.us/j/94758007294?pwd=Sk9VMGlnTXRZWWJwbnZCZUx4MlI0QT09 \nFLYER IN PDF URL:https://rna.umich.edu/events/rajesh-rao/ CATEGORIES:Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20211004T160000 DTEND;TZID=America/Detroit:20211004T170000 DTSTAMP:20260526T191738 CREATED:20210827T134403Z LAST-MODIFIED:20210930T134032Z UID:9267-1633363200-1633366800@rna.umich.edu SUMMARY:RNA Innovation Seminar: Byron Purse\, Ph.D. DESCRIPTION:“Fluorescent nucleoside analogues with new properties”\nByron Purse\, Ph.D.\nAssociate Professor\nOrganic Chemistry\nSan Diego State University \n  \n  \n  \n  \nHYBRID SEMINAR:\nIn-person: Forum Hall\, Palmer Commons\nZoom: https://umich.zoom.us/webinar/register/WN__vvE2dtHQi-R3h05JUHBzQ \nFLYER IN PDF \nAbstract:\nFluorescent nucleoside analogues (FNAs) are powerful probes for studying the structure and dynamics of nucleic acids\, which are vital to understanding RNA function\, DNA damage repair\, nucleic acid–protein interactions\, regulatory mechanisms for gene expression\, and other aspects of nucleic acid function. Existing FNAs are prone to quenching by base pairing and stacking\, are clustered at the blue–green end of the visible spectrum\, and have limited brightness as compared with conventional fluorophores. Studies of nucleic acid function would benefit greatly from overcoming these limitations. We have designed\, synthesized\, and studied a series of fluorescent pyrimidine analogues\, aiming to address these limitations and develop a detailed understanding of the relationships between chemical structure and fluorescent responses to local environment in nucleic acids. Included in this series is a tricyclic cytidine analogue DEAtC that is nearly non-fluorescent as a nucleoside\, but responds to matched base pairing and stacking with a fluorescence turn-on. A chlorinated tricyclic cytidine 8-Cl-tCO reports on local environment by changes in the vibrational fine structure of its emission spectra. To address the problem of limited brightness\, we have design and synthesized a new NFA that we call ABN\, which has a conjugated push–pull system similar to those found in bright fluorophores such as rhodamines. ABN is the brightest known FNA when present in duplex nucleic acids\, and it is readily detected in single-molecule fluorescence measurements using both 1-photon and 2-photon excitation. Collectively\, these FNAs offer new capabilities for biophysical studies on nucleic acids. Comparisons of their structure and properties help to reveal mechanisms for fluorescence changes in response to local environment in nucleic acids. URL:https://rna.umich.edu/events/byron-purse/ CATEGORIES:Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210924T100000 DTEND;TZID=America/Detroit:20210924T110000 DTSTAMP:20260526T191738 CREATED:20210901T193132Z LAST-MODIFIED:20210901T193132Z UID:9344-1632477600-1632481200@rna.umich.edu SUMMARY:Jayakrishnan Nandakumar\, MCDB DESCRIPTION:“Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites”\nJayakrishnan Nandakumar\, Ph.D.\nU-M LSI Structure Series\nLocation: LSI Library URL:https://rna.umich.edu/events/jk-nandakumar/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210922T160000 DTEND;TZID=America/Detroit:20210922T170000 DTSTAMP:20260526T191738 CREATED:20210901T191748Z LAST-MODIFIED:20210901T191748Z UID:9322-1632326400-1632330000@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: NCI RNA Biology Initiative DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-nci-rna-biology-initiative/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210921T120000 DTEND;TZID=America/Detroit:20210921T130000 DTSTAMP:20260526T191738 CREATED:20210901T190819Z LAST-MODIFIED:20210908T165943Z UID:9313-1632225600-1632229200@rna.umich.edu SUMMARY:BiolChem Seminar: Alexis Komor\, UCSD DESCRIPTION:“Base Editing-Performing Chemistry on the Genome”\nAlexis Komor\, UCSD\nDepartment of Biological Chemistry seminar\nLocation: Zoom Webinar https://umich.zoom.us/j/91821866007\nHosts: Yan Zhang and Nils Walter URL:https://rna.umich.edu/events/alexis-komor/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210914T120000 DTEND;TZID=America/Detroit:20210914T130000 DTSTAMP:20260526T191738 CREATED:20210901T191030Z LAST-MODIFIED:20210907T132755Z UID:9316-1631620800-1631624400@rna.umich.edu SUMMARY:BiolChem Seminar: Jason McLellan\, University of Texas at Austin DESCRIPTION:“Structure-Function Studies of the SARS-CoV-2 Spike and Development of COVID-19 Interventions”\nJason McLellan\, University of Texas at Austin\nDepartment of Biological Chemistry seminar\nLocation: 3330 MS I\nHost: Janet Smith URL:https://rna.umich.edu/events/jason-mclellan-university-of-texas-at-austin/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210913T160000 DTEND;TZID=America/Detroit:20210913T170000 DTSTAMP:20260526T191738 CREATED:20210827T134151Z LAST-MODIFIED:20210907T135538Z UID:9263-1631548800-1631552400@rna.umich.edu SUMMARY:RNA Innovation Seminar\, Rhiju Das\, Ph.D. DESCRIPTION:“Recent improvements in modeling and design of RNA-only structures”\nRhiju Das\, Ph.D.\nAssociate Professor\nDepartments of Biochemistry and (by courtesy) Physics\nStanford University \nRegistration: https://umich.zoom.us/webinar/register/WN_i7vWSsxDQfSVbQP1C7HGSQ \n  \nAbstract:\nThe discovery and design of biologically important RNA molecules is outpacing three-structural characterization. I’ll describe results from my and Wah Chiu’s groups that demonstrate that cryo-electron microscopy can resolve maps of several kinds of RNA-only systems. These maps enable subnanometer-resolution 3D coordinate estimation when complemented with multidimensional chemical mapping and Rosetta DRRAFTER computational modeling. If time allows\, I’ll describe work from the Eterna project to stabilize mRNA molecules to help accelerate worldwide COVID immunization. URL:https://rna.umich.edu/events/rhiju-das/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210910T160000 DTEND;TZID=America/Detroit:20210910T170000 DTSTAMP:20260526T191738 CREATED:20210901T192746Z LAST-MODIFIED:20210901T192746Z UID:9337-1631289600-1631293200@rna.umich.edu SUMMARY:Bioinnitiatives in Brain Cancer (BIBC) | Castro & Lowenstien DESCRIPTION:BIBC Hybrid Seminar Series: Dr. Pedro Lowenstein and Dr. Maria G. Castro\nDATE: Friday\, September 10\, 2021\nTIME: 4:00 pm—5:00 pm\nLOCATION: NCRC\, B10 Research Auditorium\nDr. Maria G. Castro and Dr. Pedro Lowenstein\, Richard C. Schneider Collegiate Professors of Neurosurgery will be presenting their novel work studying glioma invasion\, migration\, growth\, and the immune tumor microenvironment. \nThe BIBC seminars will showcase the multidisciplinary research of faculty studying brain cancer biology and novel technologies that can be used for brain cancer diagnosis and treatment. The seminars will be held on campus with a hybrid option. If you have not already received building access for NCRC\, enter through the Building 10 front entrance. \nAnyone attending the seminar in person must complete the ResponsiBLUE questionnaire and show the screening check when entering the research auditorium. At this time\, masks are required for all individuals regardless of vaccination status. We will update this event if University policy changes with regards to in-person events. URL:https://rna.umich.edu/events/bioinnitiatives-in-brain-cancer-bibc-castro-lowenstien/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210908T160000 DTEND;TZID=America/Detroit:20210908T170000 DTSTAMP:20260526T191738 CREATED:20210901T191545Z LAST-MODIFIED:20210901T191545Z UID:9320-1631116800-1631120400@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: Rochester DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-rochester/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210907T120000 DTEND;TZID=America/Detroit:20210907T130000 DTSTAMP:20260526T191738 CREATED:20210901T191230Z LAST-MODIFIED:20210901T191230Z UID:9318-1631016000-1631019600@rna.umich.edu SUMMARY:Dipali Sashital\, Iowa State University DESCRIPTION:“Achieving and Balancing Specificity in the CRISPR-Cas Systems”\nDipali Sashital\, Iowa State University\nDepartment of Biological Chemistry seminar\nZoom link: https://umich.zoom.us/j/91821866007\nHosts: Yan Zhang and Nils Walter URL:https://rna.umich.edu/events/dipali-sashital-iowa-state-university/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210825T090000 DTEND;TZID=America/Detroit:20210825T100000 DTSTAMP:20260526T191738 CREATED:20210415T215751Z LAST-MODIFIED:20210426T152519Z UID:8546-1629882000-1629885600@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: Institute of Molecular Biology (IMB) DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host/ CATEGORIES:Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210811T160000 DTEND;TZID=America/Detroit:20210811T170000 DTSTAMP:20260526T191738 CREATED:20210415T215644Z LAST-MODIFIED:20210517T161927Z UID:8544-1628697600-1628701200@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: RiboClub Sherbrooke DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-tba-3/ CATEGORIES:Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210728T090000 DTEND;TZID=America/Detroit:20210728T100000 DTSTAMP:20260526T191738 CREATED:20210415T215545Z LAST-MODIFIED:20210426T152555Z UID:8542-1627462800-1627466400@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: MD Anderson Center for RNA Interference and Non-Coding RNAs DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-md-anderson-center-for-rna-interference-and-non-coding-rnas/ CATEGORIES:Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210714T090000 DTEND;TZID=America/Detroit:20210714T100000 DTSTAMP:20260526T191738 CREATED:20210415T215433Z LAST-MODIFIED:20210415T215433Z UID:8540-1626253200-1626256800@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: iRNA @ Istituto Italiano di Tecnologia (IIT) DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-irna-istituto-italiano-di-tecnologia-iit/ CATEGORIES:Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210630T160000 DTEND;TZID=America/Detroit:20210630T170000 DTSTAMP:20260526T191738 CREATED:20210415T215318Z LAST-MODIFIED:20210609T182833Z UID:8538-1625068800-1625072400@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: University of Michigan DESCRIPTION:REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_6OEQ6sDAQ0-21GHm6d7VEQ\n\n“Dynamic multivalent interactions drive mammalian RNA regulation”\n \nSethu Pitchiaya\, Ph.D.\nDepartment of Urology \n\n  \n  \n  \n  \n  \n  \n  \n\n\n\n“Characterizing cellular RNA-protein interaction networks with chemical probes”\nChase Weidmann\, Ph.D.\nDepartment of Biological Chemistry \n  \n  \n  \n  \n  \n  \n  \n\nFor the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-pitchiaya-weidmann/ CATEGORIES:Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Detroit:20210616T160000 DTEND;TZID=America/Detroit:20210616T170000 DTSTAMP:20260526T191738 CREATED:20210415T215236Z LAST-MODIFIED:20210517T161849Z UID:8536-1623859200-1623862800@rna.umich.edu SUMMARY:RNA Collaborative Seminar Series // Host: Yale Center for RNA Science and Medicine DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-tba-2/ CATEGORIES:Seminar END:VEVENT END:VCALENDAR