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DTSTART;TZID=America/Detroit:20250616T160000
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SUMMARY:RNA Innovation Seminar: John Lueck\, Ph.D.\, Associate Professor\, Pharmacology and Physiology; Neurology\, University of Rochester Medical Center
DESCRIPTION:“Development of ACE-tRNAs as a platform therapeutic for nonsense-associated diseases”\nJohn D. Lueck\, Ph.D.\nAssociate Professor\nPharmacology and Physiology\nNeurology\nUniversity of Rochester Medical Center\n  \nIn-person: ABC Seminar Rooms\, BSRB | Hybrid link \nCo-hosted by the Cystic Fibrosis at UM Initiative \n\nAbstract:\nWe have generated a library of AntiCodon Edited (ACE) -tRNAs that are capable of suppressing disease-causing nonsense mutations and rescuing WT protein function. However\, to advance ACE-tRNAs as a therapeutic\, we set out to determine how well they function as a platform therapeutic\, where one ACE-tRNA sequence encoding one amino acid can be used to restore significant function of the target protein with nonsense to missense mutations. This maneuver would significantly reduce the burden of advancing several ACE-tRNA sequences through clinical trials and FDA approval. Further\, we are working to determine modalities for viral and non-viral delivery of ACE-tRNAs to different tissues. In doing so\, we have taken advantage of the diminutive size of the ACE-tRNA expression cassette to generate small DNA vectors for efficient cell delivery and nuclear targeting. \nBiography:\nThe focus of my research is to evaluate the therapeutic promise of suppressor tRNA for treatment of cystic fibrosis. In my graduate training I studied myotonia in myotonic dystrophy type 1 (DM1) in Dr. Robert Dirksen’s laboratory and in collaboration with Dr. Charles Thornton. I used both molecular biology/genetics and electrophysiology approaches to determine how the DM1-associated problems with alternative splicing affect function of ClC-1 chloride channel and muscle excitability. I showed that chloride conductance is rapidly rescued if ClC-1 splicing is corrected or if sequestration of splicing factors is released. I also investigated the effects of splicing misregulation on function of RyR1. These studies resulted in 10 publications and cemented my interest in doing translational research. Following my graduate work\, I joined Dr. Kevin Campbell’s laboratory. There I learned membrane protein biochemistry\, antibody generation and testing mouse skeletal muscle physiology testing and gene therapy approaches\, in studies focused on muscular dystrophy. This experience makes me well suited to conduct independent research using a breadth of techniques focused disease pathogenesis. My research took a turn as I became interested in the field of genetic code expansion and its use as a therapeutic for cystic fibrosis (CF) that result from nonsense mutations. I quickly published 5 studies in 3 years with Dr. Chris Ahern that propelled me to my current independent position\, where I have been able to extend my research in determining the therapeutic promise of our suppressor tRNA technologies for CF. In my next steps\, I will use my extensive training in mouse genetics\, molecular biology\, membrane biophysics and protein biochemistry to investigate the impact on cellular and tissue processes following stop codon suppression in vivo and generate new CF therapeutic deliverables that can be translated into other nonsense associated diseases. More broadly\, I’m interested in applying membrane biophysics and molecular and cellular biology approaches to elucidate the molecular underpinning of genetic diseases\, and then using mechanistic insights to develop new treatments. \nResearch interests:\nMy research focuses on the molecular genetics and experimental treatment of diseases resulting from nonsense mutations. I am investigating the use of engineered tRNAs for suppression of nonsense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) transcripts as therapeutic intervention for cystic fibrosis. Additionally\, I am interested in the molecular genetics and experimental treatment of the trinucleotide repeat disorder myotonic dystrophy (DM1). Moving forward\, I intend to study pre-mRNA splicing defects in DM1 to determine the causes of muscle weakness and wasting\, and develop and test new therapeutic strategies to target the genetic misstep and reverse symptoms. More broadly\, I’m interested in applying membrane biophysics\, molecular and cellular biology approaches to understand the molecular underpinning of genetic diseases and develop therapeutic interventions. \nLinks:\nJohn D. Lueck\, Ph.D. | University of Rochester Medical Center Faculty Page\nLueck Lab\nJohn D. Lueck | Google Scholar
URL:https://rna.umich.edu/events/rna-innovation-seminar-john-lueck-ph-d-associate-professor-pharmacology-and-physiology-neurology-university-of-rochester-medical-center/
LOCATION:BSRB – ABC Seminar rooms\, 109 Zina Pitcher Pl\, Ann Arbor\, MI\, 48109\, United States
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DTSTART;TZID=America/Detroit:20251023T190000
DTEND;TZID=America/Detroit:20251023T213000
DTSTAMP:20260416T225702
CREATED:20250911T191442Z
LAST-MODIFIED:20251017T184609Z
UID:17585-1761246000-1761255000@rna.umich.edu
SUMMARY:Cracking the Code: Phil Sharp and the Biotech Revolution - Film Screening and Post-Film Panel Discussion
DESCRIPTION: \n\nThursday\, October 23 at 7:00 PM\nMichigan Theater\n603 E Liberty St\nAnn Arbor\, MI 48104. \nTo purchase tickets\, please visit the Marquee Arts Website\nSpecial offer for current U-M students!\nUse the promo code UMRNA to unlock the Complimentary Ticket option. Good for one ticket\, while supplies last. Must show current U-M Student ID for entry.\n  \nFilm | Documentary | NR | 1h 36m | 2025 \n\nCracking the Code\, narrated by Mark Ruffalo\, is an inspiring story of vision\, perseverance\, and the power of science to change the world. Phil Sharp’s journey from a Kentucky farm boy to Nobel laureate embodies the American Dream and the triumph of entrepreneurial spirit. His 1977 groundbreaking discovery of RNA splicing rewrote the rules of molecular biology and ignited a life-saving scientific revolution\, laying the foundation for an industry that has become a cornerstone of global innovation and economic growth – and transformed the health of billions of patients worldwide. \n\nFeaturing a post-film Q&A with a panel co-presented by the University of Michigan Center for RNA Biomedicine and U-M Innovation Partnerships. Panelists include (subject to change): \nDr. Amanda Garner – Charles Walgreen Jr Professor\, Professor of Medicinal Chemistry and Director\, Interdepartmental Program in Medicinal Chemistry\, College of Pharmacy \nDr. Muneesh Tewari – Ray and Ruth Anderson-Laurence M Sprague Memorial Research Professor\, Professor of Internal Medicine\, Associate Division Chief\, Basic Research\, Medical School and Professor of Biomedical Engineering\, Medical School and College of Engineering \nDr. Nils Walter – Director\, U-M Center for RNA Biomedicine\, Francis S Collins Collegiate Professor of Chemistry\, Biophysics and Biological Chemistry\, Professor of Chemistry\, Professor of Biophysics\, College of Literature\, Science\, and the Arts\, Program Associate\, Office of Graduate and Postdoctoral Studies and Professor of Biological Chemistry\, Medical School \nKate Remus\, Senior Associate Director & Business Development Group Lead\, University of Michigan Innovation Partnerships \nAdditional panelists TBD \n  \n\n \nDownload the official flyer HERE. \nTo purchase tickets\, please visit the Marquee Arts Website \nSpecial offer for current U-M students! Use the promo code UMRNA to unlock the Complimentary Ticket option. Good for one ticket\, while supplies last. Must show current U-M Student ID for entry.
URL:https://rna.umich.edu/events/cracking-the-code-phil-sharp-and-the-biotech-revolution-film-screening-and-panel-discussion/
LOCATION:Michigan Theater\, 603 E Liberty St\, Ann Arbor\, MI\, 48104\, United States
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DTSTART;VALUE=DATE:20260306
DTEND;VALUE=DATE:20260308
DTSTAMP:20260416T225702
CREATED:20250715T195922Z
LAST-MODIFIED:20251104T220320Z
UID:17393-1772755200-1772927999@rna.umich.edu
SUMMARY:2026 RNA Symposium
DESCRIPTION:RNA Frontiers: From Mechanisms to Medicine\nThis year’s symposium explores the dynamic world of RNA\, highlighting how fundamental mechanisms and molecular machines are shaping both our understanding of cellular processes and the development of next-generation medical innovations. Through cutting-edge scientific talks and a patient advocacy panel discussion\, we will explore a wide range of topics spanning epigenetics\, genome editing\, RNA structure\, and translational research\, and discover together how RNA is propelling biological discovery from molecular intricacy to real-world impact in medicine and beyond. \n\n\n\n\nEarly bird registration is now open!\n\n\n\n\n\n\n\n\nClick here to register!\n\n\n\n\n\nThe Center for RNA Biomedicine at the University of Michigan proudly invites you to the 2026 RNA Symposium. Taking place from Friday\, March 6 to Saturday\, March 7\, 2026\, this premier event will convene thought leaders and pioneering researchers in the field of RNA science and biomedicine. \nScheduled Speakers: \nShelley Berger\, Ph.D.\nUniversity of Pennsylvania \nKarla Neugebauer\, Ph.D.\nYale School of Medicine \nMadeleine Oudin\, Ph.D.\nTufts University \nErik Sontheimer\, Ph.D.\nUMass Chan Medical School \nNils Walter\, Ph.D.\nUniversity of Michigan \nSarah Woodson\, Ph.D.\nJohns Hopkins University \n  \nDates: March 6 – 7\, 2026 \nKahn Auditorium\nBIOMEDICAL SCIENCE RESEARCH BUILDING\n109 ZINA PITCHER PLACE\nANN ARBOR\, MICHIGAN 48109\nUniversity of Michigan Ann Arbor Campus
URL:https://rna.umich.edu/events/2026-rna-symposium/
LOCATION:BSRB – Kahn Auditorium
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DTSTART;TZID=America/Detroit:20260408T100000
DTEND;TZID=America/Detroit:20260408T110000
DTSTAMP:20260416T225702
CREATED:20260408T162304Z
LAST-MODIFIED:20260413T174008Z
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SUMMARY:RNA Collaborative Seminar: April 8\, 10:00 a.m. EDT:  University of Michigan Center for RNA Biomedicine and Regensburg Center for Biochemistry
DESCRIPTION:UPDATE 4.13.2026\nThe video recording of the seminar is now available to view on our YouTube channel. Visit https://youtu.be/n7zQtI8tfMw?si=EzVmsIyAIag8QHqc\nThe next RNA Collaborative Seminar to be held virtually Wednesday\, April 8 at 10:00 a.m. EDT (Eastern\, US/Canada). \nThis seminar will be presented virtually and hosted by the University of Michigan Center for RNA Biomedicine and Regensburg Center for Biochemistry (RCB). \nZoom Registration: https://us02web.zoom.us/webinar/register/WN_eBYbfEgRTjS27HtF-HXjwQ \nWednesday\, April 8th at 10 am ET (Eastern\, US/Canada)Hosted by: University of Michigan Center for RNA Biomedicine and Regensburg Center for Biochemistry (RCB) \nFor more information about the RNA Society and the RNA Collaborative Seminar Series\, visit https://www.rnasociety.org/rna-collaborative-seminar-series/
URL:https://rna.umich.edu/events/rna-collaborative-seminar-april-8-1000-a-m-edt-university-of-michigan-center-for-rna-biomedicine-and-regensburg-center-for-biochemistry/
LOCATION:Virtual
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20260420T160000
DTEND;TZID=America/Detroit:20260420T170000
DTSTAMP:20260416T225702
CREATED:20260413T153502Z
LAST-MODIFIED:20260413T154123Z
UID:18551-1776700800-1776704400@rna.umich.edu
SUMMARY:2026 Trainee RNA Seminar - Student-Postdoc Council
DESCRIPTION:We’re excited to invite you to the next 2026 Trainee RNA Seminar on Monday\, April 20 at 4:00 p.m. EDT. \n \nThis session will feature a chalk talk workshop presented by Dr. Rachel Niederer\, Assistant Professor of Biological Chemistry\, Medical School\, Biological Chemistry Dept.\, Faculty Scholar\, Center for RNA Biomedicine. \nDr. Niederer will present her chalk talk\, discuss approaches to developing effective and engaging chalk talks\, and conclude with time for audience questions. \n\nDate. Time. Location.\nMonday\, April 20th at 4:00 PM\nABC Seminar Rooms at BSRB. \nA Zoom option will also be available. (Link will be posted here – please check back!) \nTrainees are especially encouraged to participate. We look forward to seeing you there! \nCRB Student–Postdoc Council
URL:https://rna.umich.edu/events/2026-trainee-rna-seminar-student-postdoc-council/
LOCATION:BSRB – ABC Seminar rooms\, 109 Zina Pitcher Pl\, Ann Arbor\, MI\, 48109\, United States
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20260427T160000
DTEND;TZID=America/Detroit:20260427T170000
DTSTAMP:20260416T225702
CREATED:20260413T160318Z
LAST-MODIFIED:20260413T173558Z
UID:18561-1777305600-1777309200@rna.umich.edu
SUMMARY:Student-Postdoc Council Webinar with Eclipsebio
DESCRIPTION:The Center for RNA Biomedicine Student and Postdoc Council will be hosting a webinar featuring Dr. Wayne Doyle\, Director\, Platforms and Strategy\, Eclipsebio.\n\n\n\n\n\nSpeaker: Wayne Doyle\, Ph.D. Head of Scientific Platforms and Strategy\n \nTitle of the talk: “Sequencing-first solutions for RNA therapeutic development”\n\nTime: Apr 27\, 2026 04:00 PM Eastern Time \nJoin Zoom Meeting–\nhttps://umich.zoom.us/j/93314315337 \nMeeting ID: 933 1431 5337 \n\n\nAbstract:\n \n“Despite rapid advances in RNA medicine\, many programs fail due to poorly suboptimal designs and quality issues that conventional assays fail to detect. Addressing these challenges requires both effective design algorithms and advanced analytics that provide mechanistic insight into RNA therapeutic activity and safety.\n \nIn this seminar\, Dr. Wayne Doyle (Eclipsebio) will discuss how sequencing-based approaches reveal key insights for the development of siRNA and mRNA therapeutics. Key topics include multidimensional profiling of target RNAs\, AI-powered drug design\, and sequencing-based characterization of mRNA medicines.”\n\nJoin us!\n\nStudent-Postdoc Council
URL:https://rna.umich.edu/events/student-postdoc-council-webinar-with-eclipsebio/
CATEGORIES:Seminar
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