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X-WR-CALNAME:Center for RNA Biomedicine
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X-WR-CALDESC:Events for Center for RNA Biomedicine
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DTSTART:20200308T070000
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DTSTART:20201101T060000
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210215T160000
DTEND;TZID=America/Detroit:20210215T170000
DTSTAMP:20260404T074227
CREATED:20201007T170749Z
LAST-MODIFIED:20210202T211040Z
UID:7212-1613404800-1613408400@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Karla Neugebauer\, Yale University
DESCRIPTION:“Dynamics of co-transcriptional pre-mRNA processing and assembly of related biomolecular condensates”\nProf. Karla Neugebauer\, Ph.D.\nProfessor of Molecular Biophysics and Biochemistry and of Cell Biology\nDirector of Graduate Studies\, Molecular Biophysics and Biochemistry\nDirector\, Yale Center for RNA Science and Medicine\nYale School of Medicine \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_aZggyZ0yQcSPcJrsHloXjQ \nFLYER IN PDF \nAbstract: My lab is interested in the coordination between transcription\, RNA processing and nuclear organization that governs gene expression. We have established experimental systems in budding yeast\, zebrafish embryos\, and mammalian tissue culture cells to explore transcription and splicing regulation in a variety of biological contexts and with a diversity of tools\, from imaging to genome-wide approaches. Our observations have provided novel insights into transcription and splicing mechanisms as well as principles of cellular organization that facilitate efficient gene expression. In this talk\, I will be discussing rapid co-transcriptional splicing during erythropoiesis and how Cajal bodies assemble to ensure a steady supply of spliceosomal components.
URL:https://rna.umich.edu/events/rna-innovation-seminar-karla-neugebauer/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210223T120000
DTEND;TZID=America/Detroit:20210223T130000
DTSTAMP:20260404T074227
CREATED:20210215T191752Z
LAST-MODIFIED:20210215T191857Z
UID:7988-1614081600-1614085200@rna.umich.edu
SUMMARY:BiolChem Seminar: Katrin Karbstein\, Scripps Institute Florida
DESCRIPTION:“Choreographing Ribosome Assembly”\n\nKatrin Karbstein\, Ph.D.\nScripps Institute Florida\n \nDepartment of Biological Chemistry\, Greenberg Lecture \nZoom link: https://umich.zoom.us/j/96151442305
URL:https://rna.umich.edu/events/katrin-karbstein/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210224T090000
DTEND;TZID=America/Detroit:20210224T100000
DTSTAMP:20260404T074227
CREATED:20201130T144849Z
LAST-MODIFIED:20210127T001234Z
UID:7528-1614157200-1614160800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Helmholtz Institute for RNA-based Infection Research
DESCRIPTION:Presenters:\nNeva Caliskan\, Ph.D.\nMathias Munschauer\, Ph.D.\nFor the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-helmholtz-institute-for-rna-based-infection-research-hosting/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210303T160000
DTEND;TZID=America/Detroit:20210303T170000
DTSTAMP:20260404T074227
CREATED:20210126T184444Z
LAST-MODIFIED:20210210T165451Z
UID:7825-1614787200-1614790800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Melissa J. Moore - Chief Scientific Officer\, Moderna Therapeutics
DESCRIPTION:This event was rescheduled from February 10\, 4:00 pm.\nTo attend on March 3rd\, please register again. Apologies for the inconvenience.  \nZOOM REGISTRATION REQUIRED \n“A timely confluence: The backstory of Moderna’s COVID-19 vaccine”\n \n\nMelissa Moore\, Ph.D.\,\nChief Scientific Officer\, Moderna Therapeutics \nDr. Moore will address scientists and non-scientists\, and will take live questions.  \nFLYER IN PDF \nIn her role as Chief Scientific Officer\, Platform Research\, Dr. Melissa Moore is responsible for leading mRNA biology\, delivery and computation science research at Moderna. She joined Moderna in 2016 from the University of Massachusetts Medical School\, where she served as Professor of Biochemistry & Molecular Pharmacology\, Eleanor Eustis Farrington Chair in Cancer Research and a long-time Investigator at the Howard Hughes Medical Institute (HHMI).  Dr. Moore was also a founding Co-Director of the RNA Therapeutics Institute (RTI) at UMassMed\, and was instrumental in creating the Massachusetts Therapeutic and Entrepreneurship Realization initiative (MassTERi)\, a faculty-led program intended to facilitate the translation of UMMS discoveries into drugs\, products\, technologies and companies.  Dr. Moore is an elected member of the National Academy of Sciences (2017) and a Fellow of the American Academy of Arts and Sciences (2019). \nDr. Moore holds a B.S. in Chemistry and Biology from the College of William and Mary\, and a Ph.D. in Biological Chemistry from MIT\, where she specialized in enzymology under Prof. Christopher T. Walsh.  She began working on RNA metabolism during her postdoctoral training with Phillip A. Sharp at MIT.  During her 23 years as a faculty member\, first at Brandeis and then at UMassMed\, her research encompassed a broad array of topics related to the roles of RNA and RNA-protein (RNP) complexes in gene expression\, and touched on many human diseases including cancer\, neurodegeneration\, and preeclampsia.
URL:https://rna.umich.edu/events/melissa-moore/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210309T120000
DTEND;TZID=America/Detroit:20210309T130000
DTSTAMP:20260404T074227
CREATED:20200826T130623Z
LAST-MODIFIED:20210128T144524Z
UID:6463-1615291200-1615294800@rna.umich.edu
SUMMARY:BiolChem Seminar: Lori Passmore\, MRC Laboratory of Molecular Biology
DESCRIPTION:“Mechanistic Insights into the mRNA Poly(A) Tail Machinery”\n\nLori Passmore\, Ph.D.\nMRC Laboratory of Molecular Biology\n \n  \n  \nDepartment of Biological Chemistry\, Greenberg Lecture
URL:https://rna.umich.edu/events/seminar-lori-passmore-greenberg-lecture/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210310T160000
DTEND;TZID=America/Detroit:20210310T170000
DTSTAMP:20260404T074227
CREATED:20201130T145136Z
LAST-MODIFIED:20210127T000841Z
UID:7534-1615392000-1615395600@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Alberta RNA Research and Training Institute (ARRTI)
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-tba-host-3/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210315T160000
DTEND;TZID=America/Detroit:20210315T170000
DTSTAMP:20260404T074227
CREATED:20210126T231000Z
LAST-MODIFIED:20210209T190231Z
UID:7834-1615824000-1615827600@rna.umich.edu
SUMMARY:RNA Innovation Seminar: James Nuñez\, HHMI Hanna Gray Fellow\, UCSF
DESCRIPTION:“Programmable transcriptional memory by CRISPR-based epigenome editing”\nJames Nuñez\, Ph.D.\nHHMI Hanna Gray Fellow\nUniversity of California\, San Francisco \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_hZw_8jjWQo-7goOvohXOPg \nFLYER IN PDF \n \nABSTRACT: General approaches for heritably altering gene expression would enable many discovery and therapeutic efforts. I will present CRISPRoff— a programmable epigenetic memory writer consisting of a single dead Cas9 fusion protein that establishes DNA methylation and repressive histone modifications to turn off transcription. Transient CRISPRoff expression initiates highly specific DNA methylation and gene repression that is maintained through cell division and differentiation of stem cells to neurons. Pairing CRISPRoff with genome-wide screens and analysis of chromatin marks enabled us to explore the rules for heritable silencing. We identify sgRNAs capable of silencing the large majority of genes including those lacking canonical CpG islands (CGIs) and reveal a wide targeting window extending beyond annotated CGIs. Our finding that targeted DNA methylation outside of CGIs leads to memorized gene silencing expands the canonical model of methylation-based silencing and broadly enables diverse applications including genome-wide screens\, multiplexed cell engineering\, enhancer silencing\, and mechanistic exploration of epigenetic inheritance. \nKEYWORDS: CRISPR\, transcription\, epigenetics \n 
URL:https://rna.umich.edu/events/james-nunez/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210324T160000
DTEND;TZID=America/Detroit:20210324T170000
DTSTAMP:20260404T074227
CREATED:20201130T145224Z
LAST-MODIFIED:20210127T000917Z
UID:7536-1616601600-1616605200@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: UMass Medical School\, RNA Therapeutics Institute
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-umass-medical-school-rna-therapeutics-institute-hosting/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210325T110000
DTEND;TZID=America/Detroit:20210325T143000
DTSTAMP:20260404T074227
CREATED:20210111T150038Z
LAST-MODIFIED:20210127T001326Z
UID:7702-1616670000-1616682600@rna.umich.edu
SUMMARY:5th Annual RNA Symposium: "Processing RNA" - Day 1
DESCRIPTION:Day 1\n11:00–11:05 / Welcome\n11:05–12:00 / Keynote 1: Tracy Johnson\, Ph.D.\, University of California – Los Angeles (RNA splicing)\n12:00–12:10 / Short break\n12:10–1:05 / Keynote 2: Kevin Weeks\, Ph.D.\, University of North Carolina (RNA structure in vivo)\n1:05–1:35 / Data Blitz (three finalists from the poster submissions)\n1:35–2:30 / Keynote 3: Feng Zhang\, Ph.D.\, MIT (CRISPR applications)\n2:30–2:30 / Brief closing \nREGISTRATION REQUIRED \nView full schedule here
URL:https://rna.umich.edu/events/5th-symposium-processing-rna-day-1/
CATEGORIES:Symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210326T110000
DTEND;TZID=America/Detroit:20210326T143000
DTSTAMP:20260404T074227
CREATED:20210111T150420Z
LAST-MODIFIED:20210127T001342Z
UID:7706-1616756400-1616769000@rna.umich.edu
SUMMARY:5th Annual RNA Symposium: "Processing RNA" - Day 2
DESCRIPTION:Day 2\n11:00–11:05 / Welcome\n11:05–12:00 / Keynote 4: Brenda Bass\, Ph.D.\, University of Utah (RNA editing & silencing)\n12:00–12:10 / Short break\n12:10–1:05 / Keynote 5: Christopher Lima\, Ph.D.\, Memorial Sloan-Kettering (RNA degradation)\n1:05–1:35 / Data Blitz (three finalists from the poster submissions)\n1:35–2:25 / Panel discussion with keynote speakers\n2:25–2:30 / Closing \nREGISTRATION REQUIRED \nView full schedule here
URL:https://rna.umich.edu/events/5th-symposium-processing-rna-day-2/
CATEGORIES:Symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210405T160000
DTEND;TZID=America/Detroit:20210405T170000
DTSTAMP:20260404T074227
CREATED:20210126T233354Z
LAST-MODIFIED:20210310T173437Z
UID:7838-1617638400-1617642000@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Natoya Peart\, University of Pennsylvania
DESCRIPTION:“Direct binding of ESRP1 to regulated transcripts is required for position-dependent splicing regulation”\nNatoya Peart\, Ph.D.\nPostdoctoral Researcher – Carstens Lab/Lynch Lab\nDepartment of Medicine/Department of Biochemistry and Molecular Biophysics\nUniversity of Pennsylvania \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_0lUfePb0Qdac-cQZDpeiEQ \nFLYER IN PDF \nKEYWORDS: Alternative splicing\, RNAMap\, Esrp1 \nABSTRACT: Coordinated regulation of alternative splicing is essential to the establishment of cell identity. The Epithelial Splicing Regulatory Proteins (Esrps)\, ESRP1 and ESRP2\, are highly conserved paralogous proteins required for organogenesis of multiple organ systems and compromised function of Esrps contributes to human diseases and pathologies. Esrps are robustly expressed in the epithelial cells of the epidermis\, large and small intestines\, salivary glands\, stomach\, and a variety of other tissues\, where they are vital in promoting an epithelial splicing network. Although ESRP1 and ESRP2 share partial functional redundancy\, ESRP1 appears to play a larger role in regulating gene expression.\nUsing a combination of enhanced immunoprecipitation coupled with high throughput sequencing (eCLIP) in the epithelial cells of mouse epidermis and RNA sequencing analysis of alterations in splicing and total gene expression that result from epidermal ablation of Esrp1 and Esrp2 we generate a map of Esrp1 binding to RNA. We show that ESRP1 regulates splicing primarily through direct binding in a position-dependent manner to either promote exon inclusion or skipping. In particular\, we show that Esrp1 binding upstream of or withing alternatively spliced exons suppresses exon inclusion\, whilst binding downstream of the non-constitutive exon promotes exon inclusion. In addition\, we identified widespread binding of ESRP1 in 3’ and 5’ untranslated regions (UTRs) of genes enriched for epithelial cell function suggesting that it directly regulates post-transcriptional gene expression steps in addition to splicing.
URL:https://rna.umich.edu/events/natoya-peart/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210406T120000
DTEND;TZID=America/Detroit:20210406T130000
DTSTAMP:20260404T074227
CREATED:20200826T131104Z
LAST-MODIFIED:20210405T190959Z
UID:6468-1617710400-1617714000@rna.umich.edu
SUMMARY:Seminar: Eva Nogales\, Ludwig Lecture
DESCRIPTION:“Exploring the Modularity of Large Complexes Involved in Transcription Initiation and Chromatin Modifications” \n\nEva Nogales\, PhD\nHoward Hughes Medical Institute investigator\, Professor of Biochemistry and Molecular Biology\nUniversity of California\, Berkeley \nSenior Faculty Scientist\nLawrence Berkeley National Laboratory\n \nDepartment of Biological Chemistry\, Ludwig Lecture
URL:https://rna.umich.edu/events/seminar-eva-nogales-ludwig-lecture/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210407T160000
DTEND;TZID=America/Detroit:20210407T170000
DTSTAMP:20260404T074227
CREATED:20210104T143303Z
LAST-MODIFIED:20210127T001017Z
UID:7657-1617811200-1617814800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Bay Area RNA Club (BARC)
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-bay-area-rna-club-barc/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210413T160000
DTEND;TZID=America/Detroit:20210413T170000
DTSTAMP:20260404T074227
CREATED:20210405T150818Z
LAST-MODIFIED:20210407T130407Z
UID:8417-1618329600-1618333200@rna.umich.edu
SUMMARY:Stephanie Moon\, Ph.D.\, "RNA regulation in proteotoxic stress and genetic neurological disorders"
DESCRIPTION:“RNA regulation in proteotoxic stress and genetic neurological disorders” \n\nStephanie Moon\, PhD\nAssistant Professor of Human Genetics\, a Faculty Scholar of the Center for RNA Biomedicine\, and an Affiliate Faculty of Biological Chemistry at the University of Michigan \nFaculty Host: Sundeep Kalantry\, PhD\, Associate Professor of Human Genetics \nZoom link: https://umich-health.zoom.us/j/92442599246 \nFLYER IN PDF \nCenter for Cell Plasticity and Organ Design Seminar
URL:https://rna.umich.edu/events/stephanie-moon/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210419T160000
DTEND;TZID=America/Detroit:20210419T170000
DTSTAMP:20260404T074227
CREATED:20210128T141644Z
LAST-MODIFIED:20210310T212447Z
UID:7864-1618848000-1618851600@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Jailson (Jay) Brito Querido\, MRC Laboratory of Molecular Biology
DESCRIPTION:“Structural insights into mRNA translation initiation in humans”\nJailson (Jay) Brito Querido\, Ph.D.\nPostdoctoral Scientist\nMRC Laboratory of Molecular Biology\nCambridge\, UK \nZOOM \nFLYER IN PDF \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_78YYOhIhTbOBy2_JSdM7Wg \nABSTRACT: A key step in translational initiation is the recruitment of the 43S pre-initiation complex (43S PIC) by the cap-binding complex (eIF4F) at the 5´ end of mRNA. Eukaryotic initiation factors eIF1\, eIF1A\, eIF3\, eIF5\, and the ternary complex (TC) of eIF2–GTP–tRNAiMet bind to the 40S ribosomal subunit to form the 43S PIC. Once assembled\, the 43S PIC is recruited to the cap-binding complex eIF4F at the 5´end of mRNA to form a 48S initiation complex (48S). The 48S then scans along the mRNA to locate a start codon. To understand the mechanisms involved\, we determined the structure of a reconstituted human 48S using cryo-electron microscopy. The structure reveals insights into early events of translation initiation complex assembly. It reveals how eIF4F interacts with subunits of the eIF3 structural core near the mRNA exit channel in the 43S. The location of eIF4F is consistent with a slotting model of mRNA recruitment and suggests a “blind-region” that would preclude recognition of start sites upstream of the location of the P site at the point of recruitment. \nKEYWORDS: mRNA\, ribosome\, eIF4F\, eIF4A\, translation
URL:https://rna.umich.edu/events/jay-querido/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210421T090000
DTEND;TZID=America/Detroit:20210421T100000
DTSTAMP:20260404T074227
CREATED:20210104T143404Z
LAST-MODIFIED:20210415T215048Z
UID:7659-1618995600-1618999200@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Shanghai RNA Club
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-tba-host-4/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210503T160000
DTEND;TZID=America/Detroit:20210503T170000
DTSTAMP:20260404T074227
CREATED:20210126T234652Z
LAST-MODIFIED:20210413T174229Z
UID:7841-1620057600-1620061200@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Olivia Rissland\, University of Colorado School of Medicine
DESCRIPTION:“Regulating the Regulators: Control of RNA Binding Proteins during Embryogenesis”\nOlivia Rissland\, Ph.D.\nAssistant Professor\nRNA Bioscience Initiative | Department of Biochemistry & Molecular Genetics\nUniversity of Colorado School of Medicine \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_vA9zYS5nSEenf8Zmt1f-qA \nFLYER IN PDF \n  \nABSTRACT: The maternal-to-zygotic transition (MZT) is a conserved step in animal development\, where control is passed from the maternal to the zygotic genome. Although the MZT is typically considered from its impact on the transcriptome\, we previously found that three maternally deposited Drosophila RNA binding proteins (ME31B\, Trailer Hitch [TRAL]\, and Cup) are also cleared during the MZT by unknown mechanisms. Here\, we show that these proteins are degraded by the ubiquitin-proteasome system. Marie Kondo\, an E2 conjugating enzyme\, and the E3 CTLH ligase are required for the destruction of ME31B\, TRAL\, and Cup. Structure modeling of the Drosophila CTLH complex suggests that substrate recognition is different than orthologous complexes. Despite occurring hours earlier\, egg activation mediates clearance of these proteins through the Pan Gu kinase\, which stimulates translation of Kondo mRNA. Clearance of the maternal protein dowry thus appears to be a coordinated\, but as-yet underappreciated\, aspect of the MZT.
URL:https://rna.umich.edu/events/olivia-rissland/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210504T150000
DTEND;TZID=America/Detroit:20210504T160000
DTSTAMP:20260404T074227
CREATED:20210416T182959Z
LAST-MODIFIED:20210416T182959Z
UID:8551-1620140400-1620144000@rna.umich.edu
SUMMARY:Seminar: Tatjana Trcek\, Johns Hopkins University
DESCRIPTION:Zoom link \n“RNA Granules: A View from the RNA Perspective”\nTatjana Trcek\, PhD\nAssistant Professor\nDepartment of Biology\nJohns Hopkins University\n  \nHosted by:\nStephanie Moon\, Ph.D.\nAssistant Professor of Human Genetics\nFaculty Scholar of the Center for RNA Biomedicine\nAffiliate Faculty\, Biological Chemistry\nFLYER IN PDF \nDepartment of Human Genetics Seminar \n  \n 
URL:https://rna.umich.edu/events/seminar-tatjana-trcek-johns-hopkins-university/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210505T090000
DTEND;TZID=America/Detroit:20210505T100000
DTSTAMP:20260404T074227
CREATED:20210104T143436Z
LAST-MODIFIED:20210426T152958Z
UID:7661-1620205200-1620208800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Cambridge RNA Club
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-tba-host-5/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210517T160000
DTEND;TZID=America/Detroit:20210517T170000
DTSTAMP:20260404T074227
CREATED:20210126T235922Z
LAST-MODIFIED:20210512T200602Z
UID:7845-1621267200-1621270800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Thomas Martinez\, Salk Institute for Biological Studies
DESCRIPTION:“Annotation and Characterization of Human Protein-coding Small Open Reading Frames”\nThomas Martinez\, Ph.D.\nPostdoctoral Fellow\nSalk Institute for Biological Studies \nZOOM \nREGISTRATION REQUIRED:\nhttps://umich.zoom.us/webinar/register/WN_90RkcQTGQZa7ifQ8kbSdNQ \nFLYER IN PDF \nKEYWORDS: microprotein\, smORF\, ribosome profiling \nABSTRACT: Functional protein-coding small open reading frames (smORFs) are emerging as an important class of genes. Several smORF-encoded microproteins have been characterized and implicated in a variety of critical processes\, including regulation of mRNA decay\, DNA repair\, and muscle formation. Thus\, rigorous and comprehensive annotation of protein-coding smORFs is critical to our understanding of basic biology and physiology\, as well as disease. We recently developed an improved workflow that integrates de novo transcriptome assembly and ribosome profiling to overcome obstacles with previous methods to more confidently annotate thousands of novel smORFs across multiple human cell lines\, including hundreds encoded on putative non-coding RNAs. Over 1\,500 smORFs are found in two or more cell lines\, and ~40% lack a canonical AUG start codon. Evolutionary conservation analyses suggest that hundreds of smORF-encoded microproteins are likely functional. We also find that smORF-derived peptides are detectable on human leukocyte antigen complexes\, positioning smORFs as a source of novel antigens. The annotation of protein-coding smORFs radically alters the current view of the human genome’s coding capacity and will provide a rich pool of unexplored\, functional human genes. \nBIOGRAPHY: Thomas received his B.S. in Biological Engineering from MIT and trained in Prof. JoAnne Stubbe’s laboratory\, where he studied the mechanism of ribonucleotide reductase. He then received his Ph.D. in Biochemistry & Molecular Biophysics from Caltech as an NIH NRSA predoctoral fellow under the mentorship of Prof. Peter Dervan. His thesis work focused primarily on characterizing the effects of DNA binding pyrrole-imidazole polyamides on DNA replication in prostate cancer cells. Thomas is currently an NIH NRSA postdoctoral fellow in Prof. Alan Saghatelian’s laboratory\, where he has developed an integrative platform combining ribosome profiling and de novo transcriptome assembly to discover functional smORF encoded microproteins in the human genome.
URL:https://rna.umich.edu/events/thomas-martinez/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210518T160000
DTEND;TZID=America/Detroit:20210518T170000
DTSTAMP:20260404T074227
CREATED:20210517T161112Z
LAST-MODIFIED:20210517T163536Z
UID:8681-1621353600-1621357200@rna.umich.edu
SUMMARY:Seminar: Nick Ingolia\, UC Berkeley
DESCRIPTION:ZOOM LINK \n“Dissecting gene regulatory networks with CiBER-Seq”\nNicholas Ingolia\, PhD\nAssistant Professor\nDepartment of Molecular & Cell Biology\nUniversity of California\, Berkeley\nFaculty host:\nKristin Koutmou\, Ph.D.\nSeyhan N. Ege Assistant Professor of Chemistry\nDepartment of Chemistry\nDepartment of Chemistry Seminar \nABSTRACT: Cells integrate environmental signals and internal physiology to dynamically control gene expression. We have developed a technique to dissect this regulatory logic by linking targeted\, genome-wide genetic perturbations with a deep-sequencing readout that quantitatively measures the expression phenotype induced by each perturbation. Our approach combines CRISPR interference (CRISPRi) with barcoded expression reporters (CiBER-seq) to profile transcriptional\, translational\, and posttranslational regulatory responses\, connecting each guide in a genome-scale library with its individual phenotypic consequences. Applying CiBER-Seq to the well-studied integrated stress response (ISR) pathway recapitulated the known biology of this pathway and uncovered further triggers for ISR activation that were not previously appreciated. The quantitative phenotypic measurements from CiBER-Seq are well suited to epistasis analysis\, and we measure dual-perturbation phenotypes and compare patterns of genetic interaction to gain further insight into regulatory pathways. CiBER-Seq is an incisive tool for dissecting genetic networks\, and can be applied to study a wide range of biological processes\, using gene expression regulation as a sensitive and specific readout of the state of the cell. \n 
URL:https://rna.umich.edu/events/nick-ingolia-uc-berkeley/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210519T090000
DTEND;TZID=America/Detroit:20210519T100000
DTSTAMP:20260404T074227
CREATED:20210415T215014Z
LAST-MODIFIED:20210426T152937Z
UID:8528-1621414800-1621418400@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Groupe de Recherche RNA (GDR)
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-groupe-de-recherche-rna-gdr/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20210525
DTEND;VALUE=DATE:20210606
DTSTAMP:20260404T074227
CREATED:20210126T220010Z
LAST-MODIFIED:20210126T230016Z
UID:7829-1621900800-1622937599@rna.umich.edu
SUMMARY:26th Annual RNA Society Virtual meeting
DESCRIPTION:For more details\, visit: https://www2.rnasociety.org/conferences/rna-2021/ \n2021 ORGANIZERS: \nGene Yeo – University of California San Diego\, USA \nJörg Vogel – University of Würzburg\, Germany\nKatrin Karbstein – Scripps Research Institute\, Florida\, USA\nXavier Roca – Nanyang Technological University\, Singapore\nV. Narry Kim – Seoul National University\, South Korea\nAnna Marie Pyle – Yale University\, USA
URL:https://rna.umich.edu/events/26th-annual-rna-society-virtual-meeting/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210602T160000
DTEND;TZID=America/Detroit:20210602T170000
DTSTAMP:20260404T074227
CREATED:20210415T215152Z
LAST-MODIFIED:20210517T161826Z
UID:8534-1622649600-1622653200@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: European Molecular Biology Laboratory (EMBL)
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-tba/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210614T160000
DTEND;TZID=America/Detroit:20210614T170000
DTSTAMP:20260404T074227
CREATED:20210428T133100Z
LAST-MODIFIED:20210518T173059Z
UID:8623-1623686400-1623690000@rna.umich.edu
SUMMARY:RNA Innovation Seminar featuring Rising Scholars: Khan & McMillan
DESCRIPTION:Registration: https://umich.zoom.us/webinar/register/WN_uLz-ONHVQPuRINMYUNvBJQ \nFlyer: Khan & McMillan Seminar flyer \n\n“CCR5 as a model to examine reporter assays in evaluating translational phenomena”\nYousuf Khan\nKnight-Hennessy Scholar\nNSF fellow\nStanford University \n  \n  \n  \n  \nKeywords: dual luciferase\, frameshifting\, recoding\, CCR5 \nAbstract: During the decoding of a subset of mRNAs\, a proportion of ribosomes productively shift to the −1 reading frame at specific slippage-prone sites in a phenomenon known as programmed −1 ribosomal frameshifting (−1 PRF) to generate a frameshifted\, C-terminally unique protein. The first experimentally verified occurrence of functionally utilized non-retroelement derived −1 PRF in humans has been reported in the mRNA encoding the immune-functioning C-C chemokine receptor 5 (CCR5). Here\, we show that frameshifting does not occur during CCR5 decoding. Apart from its importance in understanding expression of a gene relevant to cancer\, an HIV-1 receptor (and the associated claimed rationale for generating the first humans derived from genetically modified embryos)\, the findings imply that caution is appropriate in assessing results from translational reporter assays. \n~and~\n“Intersection between RNA methylation and TDP43-mediated toxicity in ALS”\n \n  \nMike McMillan\nPh.D. candidate\nCellular and Molecular Biology\nUniversity of Michigan \n  \n  \n  \nKeywords: TDP43\, m6A\, ALS\, RNA stability \nAbstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease resulting in the death of upper and lower motor neurons. ALS has no known cure and limited therapeutic options\, and the underlying pathological mechanisms remain unclear. Despite considerable variability in clinical presentation\, over 95% of ALS cases exhibit cytoplasmic inclusions of the RNA binding protein TDP43. Emerging evidence suggests that TDP43 is crucial for RNA stability\, and that dysregulation of RNA homeostasis may contribute to ALS pathogenesis.\nMethylation of RNA at the 6th position nitrogen (N6-methyladenosine methylation\, or m6A) by methyltransferases (writers) or removal of methyl groups by demethylases (erasers) has dramatic effects on RNA stability and translation mediated by a family of RNA biding proteins that recognize methylated RNA (readers). m6A writers and erasers specifically localize to nuclear speckles\, membraneless nuclear organelles rich in RNA binding proteins and splicing factors\, including TDP43. Together with our data showing that TDP43 regulates RNA stability\, these observations suggest that TDP43 may destabilize m6A modified RNA. Here\, we show that methylated RNA co-purified with TDP43 from cultured cells via RNA immunoprecipitation\, and abrogation of methylation sites disrupted TDP43 binding\, suggesting that TDP43 recognizes m6A modified RNA in cellulo. We also noted profound and widespread hypermethylation of coding and non-coding transcripts in ALS spinal cord\, many overlapping with confirmed TDP43 target transcripts. Consistent with a central role for m6A modification in TDP43-mediated toxicity\, we identified several factors operating within the m6A pathway that enhance or suppress the toxicity of TDP43 in rodent primary cortical neurons via a single-cell CRISPR/Cas9 candidate-based screen. Genetic knockout of the established m6A reader YTHDF2 rescued TDP43 toxicity in primary neurons\, and YTHDF2 was also upregulated in ALS postmortem sections. Together\, these data imply a fundamental link between m6A RNA modifications and ALS pathogenesis\, potentially mediated by TDP43-dependent RNA destabilization. \n 
URL:https://rna.umich.edu/events/rising-scholars-khan-mcmillan/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210616T160000
DTEND;TZID=America/Detroit:20210616T170000
DTSTAMP:20260404T074227
CREATED:20210415T215236Z
LAST-MODIFIED:20210517T161849Z
UID:8536-1623859200-1623862800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Yale Center for RNA Science and Medicine
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-tba-2/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210630T160000
DTEND;TZID=America/Detroit:20210630T170000
DTSTAMP:20260404T074227
CREATED:20210415T215318Z
LAST-MODIFIED:20210609T182833Z
UID:8538-1625068800-1625072400@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: University of Michigan
DESCRIPTION:REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_6OEQ6sDAQ0-21GHm6d7VEQ\n\n“Dynamic multivalent interactions drive mammalian RNA regulation”\n \nSethu Pitchiaya\, Ph.D.\nDepartment of Urology \n\n  \n  \n  \n  \n  \n  \n  \n\n\n\n“Characterizing cellular RNA-protein interaction networks with chemical probes”\nChase Weidmann\, Ph.D.\nDepartment of Biological Chemistry \n  \n  \n  \n  \n  \n  \n  \n\nFor the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-pitchiaya-weidmann/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210714T090000
DTEND;TZID=America/Detroit:20210714T100000
DTSTAMP:20260404T074227
CREATED:20210415T215433Z
LAST-MODIFIED:20210415T215433Z
UID:8540-1626253200-1626256800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: iRNA @ Istituto Italiano di Tecnologia (IIT)
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-irna-istituto-italiano-di-tecnologia-iit/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210728T090000
DTEND;TZID=America/Detroit:20210728T100000
DTSTAMP:20260404T074227
CREATED:20210415T215545Z
LAST-MODIFIED:20210426T152555Z
UID:8542-1627462800-1627466400@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: MD Anderson Center for RNA Interference and Non-Coding RNAs
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-md-anderson-center-for-rna-interference-and-non-coding-rnas/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210811T160000
DTEND;TZID=America/Detroit:20210811T170000
DTSTAMP:20260404T074227
CREATED:20210415T215644Z
LAST-MODIFIED:20210517T161927Z
UID:8544-1628697600-1628701200@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: RiboClub Sherbrooke
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-tba-3/
CATEGORIES:Seminar
END:VEVENT
END:VCALENDAR