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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210303T160000
DTEND;TZID=America/Detroit:20210303T170000
DTSTAMP:20260403T142004
CREATED:20210126T184444Z
LAST-MODIFIED:20210210T165451Z
UID:7825-1614787200-1614790800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Melissa J. Moore - Chief Scientific Officer\, Moderna Therapeutics
DESCRIPTION:This event was rescheduled from February 10\, 4:00 pm.\nTo attend on March 3rd\, please register again. Apologies for the inconvenience.  \nZOOM REGISTRATION REQUIRED \n“A timely confluence: The backstory of Moderna’s COVID-19 vaccine”\n \n\nMelissa Moore\, Ph.D.\,\nChief Scientific Officer\, Moderna Therapeutics \nDr. Moore will address scientists and non-scientists\, and will take live questions.  \nFLYER IN PDF \nIn her role as Chief Scientific Officer\, Platform Research\, Dr. Melissa Moore is responsible for leading mRNA biology\, delivery and computation science research at Moderna. She joined Moderna in 2016 from the University of Massachusetts Medical School\, where she served as Professor of Biochemistry & Molecular Pharmacology\, Eleanor Eustis Farrington Chair in Cancer Research and a long-time Investigator at the Howard Hughes Medical Institute (HHMI).  Dr. Moore was also a founding Co-Director of the RNA Therapeutics Institute (RTI) at UMassMed\, and was instrumental in creating the Massachusetts Therapeutic and Entrepreneurship Realization initiative (MassTERi)\, a faculty-led program intended to facilitate the translation of UMMS discoveries into drugs\, products\, technologies and companies.  Dr. Moore is an elected member of the National Academy of Sciences (2017) and a Fellow of the American Academy of Arts and Sciences (2019). \nDr. Moore holds a B.S. in Chemistry and Biology from the College of William and Mary\, and a Ph.D. in Biological Chemistry from MIT\, where she specialized in enzymology under Prof. Christopher T. Walsh.  She began working on RNA metabolism during her postdoctoral training with Phillip A. Sharp at MIT.  During her 23 years as a faculty member\, first at Brandeis and then at UMassMed\, her research encompassed a broad array of topics related to the roles of RNA and RNA-protein (RNP) complexes in gene expression\, and touched on many human diseases including cancer\, neurodegeneration\, and preeclampsia.
URL:https://rna.umich.edu/events/melissa-moore/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210224T090000
DTEND;TZID=America/Detroit:20210224T100000
DTSTAMP:20260403T142004
CREATED:20201130T144849Z
LAST-MODIFIED:20210127T001234Z
UID:7528-1614157200-1614160800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Helmholtz Institute for RNA-based Infection Research
DESCRIPTION:Presenters:\nNeva Caliskan\, Ph.D.\nMathias Munschauer\, Ph.D.\nFor the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-helmholtz-institute-for-rna-based-infection-research-hosting/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210223T120000
DTEND;TZID=America/Detroit:20210223T130000
DTSTAMP:20260403T142004
CREATED:20210215T191752Z
LAST-MODIFIED:20210215T191857Z
UID:7988-1614081600-1614085200@rna.umich.edu
SUMMARY:BiolChem Seminar: Katrin Karbstein\, Scripps Institute Florida
DESCRIPTION:“Choreographing Ribosome Assembly”\n\nKatrin Karbstein\, Ph.D.\nScripps Institute Florida\n \nDepartment of Biological Chemistry\, Greenberg Lecture \nZoom link: https://umich.zoom.us/j/96151442305
URL:https://rna.umich.edu/events/katrin-karbstein/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210215T160000
DTEND;TZID=America/Detroit:20210215T170000
DTSTAMP:20260403T142004
CREATED:20201007T170749Z
LAST-MODIFIED:20210202T211040Z
UID:7212-1613404800-1613408400@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Karla Neugebauer\, Yale University
DESCRIPTION:“Dynamics of co-transcriptional pre-mRNA processing and assembly of related biomolecular condensates”\nProf. Karla Neugebauer\, Ph.D.\nProfessor of Molecular Biophysics and Biochemistry and of Cell Biology\nDirector of Graduate Studies\, Molecular Biophysics and Biochemistry\nDirector\, Yale Center for RNA Science and Medicine\nYale School of Medicine \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_aZggyZ0yQcSPcJrsHloXjQ \nFLYER IN PDF \nAbstract: My lab is interested in the coordination between transcription\, RNA processing and nuclear organization that governs gene expression. We have established experimental systems in budding yeast\, zebrafish embryos\, and mammalian tissue culture cells to explore transcription and splicing regulation in a variety of biological contexts and with a diversity of tools\, from imaging to genome-wide approaches. Our observations have provided novel insights into transcription and splicing mechanisms as well as principles of cellular organization that facilitate efficient gene expression. In this talk\, I will be discussing rapid co-transcriptional splicing during erythropoiesis and how Cajal bodies assemble to ensure a steady supply of spliceosomal components.
URL:https://rna.umich.edu/events/rna-innovation-seminar-karla-neugebauer/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210204T120000
DTEND;TZID=America/Detroit:20210204T130000
DTSTAMP:20260403T142004
CREATED:20201014T180836Z
LAST-MODIFIED:20210114T205907Z
UID:7290-1612440000-1612443600@rna.umich.edu
SUMMARY:LSI Seminar: Blanton S. Tolbert\, Ph.D.\, Case Western Reserve University
DESCRIPTION:Structural biophysics of RNA interactions that contribute to viral replication\nBlanton S. Tolbert\, Ph.D.\nProfessor of Chemistry\nCase Western Reserve University\n \nLSI Seminar Series \nInterests: Biochemistry\, Biophysical Chemistry\, Structural Biology \nBlanton S. Tolbert is a professor of chemistry at Case Western Reserve University\, where he oversees a diverse research group that endeavors to understand biochemical mechanisms by which human pathogenic RNA viruses replicate within cells\, and to leverage this knowledge to identify novel drug targets for therapeutic intervention. Tolbert is the PI of multiple NIH grants\, and he has published in top journals including Nature Communications\, the Proceedings of the National Academy of Sciences and the Journal of the American Chemical Society. Tolbert also serves on the NIH Office of AIDS Research Advisory Council (OARAC)\, and he will become the next chair of OARAC in 2021. He is a member of the Burroughs Wellcome Fund Postdoctoral Enrichment Program Advisory Board and an editor for the Journal of Biological Chemistry and Microbiology and Molecular Biology Reviews. Tolbert is the proud father of two boys\, and in his spare time he enjoys exploring the outdoors in the Cleveland Metroparks.
URL:https://rna.umich.edu/events/lsi-seminar-blanton-s-tolbert-ph-d-case-western-reserve-university/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210201T160000
DTEND;TZID=America/Detroit:20210201T170000
DTSTAMP:20260403T142004
CREATED:20200521T151621Z
LAST-MODIFIED:20210128T223131Z
UID:5820-1612195200-1612198800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Jeff Twiss\, University of South Carolina
DESCRIPTION:“Regulating the axonal proteome through mRNA transport and translation”\n\nJeffrey L. Twiss\, M.D.\, Ph.D.\nSmartState Chair in Childhood Neurotherapeutics\nProfessor of Biological Sciences\nUniversity of South Carolina\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_Rss4i-7WTwyf8m8ogCPXEQ \n  \n  \nFLYER IN PDF \nAbstract: Neurons are extremely polarized cells with axonal and dendritic processes extending 100 to 1000 fold longer or more than the cell body diameter. Our lab has been interested in how axons grow to such great distances and how they respond to injury. mRNAs are transported into axons\, with their localized translation providing the axon with autonomy to respond to different stimuli by modifying their local proteome. Transport\, translation\, and stability of axonal mRNAs is driven by interactions with RNA binding proteins and different signaling cascades. I will focus on recent work that gives insight into how specificity of these mechanisms is driven for different cohorts of axonal mRNAs. \nKeywords: Neuron\, Axon\, RNA transport\, Translational regulation
URL:https://rna.umich.edu/events/jeff-twiss/
LOCATION:Virtual
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210125T090000
DTEND;TZID=America/Detroit:20210125T100000
DTSTAMP:20260403T142004
CREATED:20200819T124758Z
LAST-MODIFIED:20210104T173802Z
UID:6382-1611565200-1611568800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Elena Conti\, Max Planck Institute of Biochemistry
DESCRIPTION:Talk title: The RNA exosome complex: the Dr Jekyll and Mr Hyde of RNA degradation\nElena Conti\, PhD\nDirector\, Max Planck Institute of Biochemistry\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_IjnWw1UcRkW8zcDeuAM2tQ \n  \nFlyer in PDF \nKeywords: molecular mechanisms\, RNA\, ribosome\, biochemistry\, cryo-EM\, X-ray crystallography \nAbstract: All RNAs in eukaryotic cells are eventually degraded. The RNA exosome is a conserved macromolecular machine that degrades a vast number and variety of RNAs. Exosome-mediated RNA degradation leads to the complete elimination of nuclear and cytoplasmic transcripts in turnover and quality control pathways\, and to the partial trimming of RNA precursors in nuclear processing pathways. How the exosome combines specificity and versatility to either eliminate or process RNAs has been a long-standing question. \nOver the years\, our group has used biochemical and structural approaches to understand how the exosome core complex channels RNA substrates for degradation and how it associates with its nuclear and cytoplasmic cofactors. Visualizing how the exosome cofactors interact with pre-ribosomes in the nucleus and with mature ribosomes in the cytoplasm has provided insights into the mechanisms with which different exosome-ribosome assemblies underpin opposite outcomes of RNA degradation: a constructive function of the nuclear exosome in the maturation of the large ribosomal subunit and a destructive function of the cytoplasmic exosome in the destruction of ribosome-bound mRNAs. Ongoing work is uncovering the unanticipated levels of regulation intrinsic to this multi-purpose degradation machinery. \nOur group has a long-standing interest in RNA metabolism\, with a particular focus on the molecular mechanisms of eukaryotic RNA transport and degradation. >more
URL:https://rna.umich.edu/events/elena-conti-max-planck-institute-of-biochemistry/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210113T160000
DTEND;TZID=America/Detroit:20210113T170000
DTSTAMP:20260403T142004
CREATED:20201014T174252Z
LAST-MODIFIED:20201014T174404Z
UID:7287-1610553600-1610557200@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - NCI RNA Biology Initiative hosting
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-nci-rna-biology-initiative-hosting/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201216T090000
DTEND;TZID=America/Detroit:20201216T100000
DTSTAMP:20260403T142004
CREATED:20201014T174059Z
LAST-MODIFIED:20201014T174059Z
UID:7284-1608109200-1608112800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - European Molecular Biology Laboratory (EMBL) hosting
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-european-molecular-biology-laboratory-embl-hosting/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201214T160000
DTEND;TZID=America/Detroit:20201214T170000
DTSTAMP:20260403T142004
CREATED:20200818T125311Z
LAST-MODIFIED:20201202T175346Z
UID:6378-1607961600-1607965200@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Narry Kim\, Seoul National University
DESCRIPTION:“RNA-based regulation of viruses”\nNarry Kim\, PhD\nProfessor\, School of Biological Sciences\nSeoul National University\nFounding Director\, RNA Research Center\nInstitute for Basic Science\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_c9BFJM9dRGKn1WFF4L_wLg \nFLYER IN PDF \nAbstract: Viruses rely heavily on RNA binding proteins for their success as pathogens. In this presentation\, I will first talk about RNA tail modification which impacts viral and cellular gene expression. We found that TENT4 enzymes extend poly(A) tail of mRNAs with ‘mixed tails’ to delay deadenylation and stabilize the RNAs. Hepatitis B virus and human cytomegalovirus hijack this mechanism to efficiently stabilize their own RNAs. In the later part of my presentation\, I will discuss our recent work on SARS-CoV-2. To delineate the viral transcriptomic architecture and provide a high-resolution map of SARS-CoV-2\, we performed deep sequencing of infected cells. Our data define the canonical transcripts and noncanonical transcripts encoding unknown ORFs. More recently\, we have also performed proteomic analyses of the SARS-CoV-2 ribonucleoprotein complex. We identify many proteins that directly interact with viral RNAs and modulate viral growth. Functional investigation of the viral transcripts and host proteins discovered in this study will open new directions to the research efforts to elucidate the life cycle and pathogenicity of SARS-CoV-2. \n  \nBio: Narry Kim is a Professor in the School of Biological Sciences at Seoul National University and a founding director of RNA Research Center at Institute for Basic Science. She received her Ph.D. in 1998 from the University of Oxford where she studied lentiviruses and gene delivery. With keen interest in RNA biology\, she joined the Gideon Dreyfuss lab at the University of Pennsylvania and researched the role of the exon junction complex in mRNA surveillance. Her current research group investigates how genes are regulated at the RNA level\, with particular interests in microRNA\, mRNA\, and viral RNA. She is a recipient of the L’Oreal-UNESCO Women in Science Award\, Hoam Prize\, and Asan Prize\, and a member of KAS\, NAS and EMBO.
URL:https://rna.umich.edu/events/seminar-narry-kim-seoul-national-university/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201207T170000
DTEND;TZID=America/Detroit:20201207T180000
DTSTAMP:20260403T142004
CREATED:20200818T124310Z
LAST-MODIFIED:20201201T223204Z
UID:6372-1607360400-1607364000@rna.umich.edu
SUMMARY:RNA Innovation Seminar: John Mattick\, University of New South Wales\, Sydney\, Australia
DESCRIPTION:RNA at the epicenter of cell and developmental biology\n\nJohn Mattick\, Ph.D.\nProfessor of RNA Biology\nSchool of Biotechnology and Biomolecular Sciences\nUniversity of New South Wales\, Sydney\, Australia\n\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_fCIiMkveTdq3D9-PKFLm6Q \nFLYER IN PDF \nABSTRACT: The genomic programming of the development of complex organisms appears to have been misunderstood. The human genome contains just ~20\,000 protein-coding genes\, similar in number and with largely orthologous functions as those in other animals\, including simple nematodes with only 1\,000 somatic cells. By contrast\, the extent of non-protein-coding DNA increases with increasing developmental complexity\, reaching 98.8% in humans. Moreover\, it is now clear that the majority of the genome is not junk but is differentially and dynamically transcribed to produce not only mRNAs but also tens if not hundreds of thousands of short and long non-protein-coding RNAs that show specific expression patterns and subcellular locations. Many of these noncoding RNAs have evolved rapidly under positive selection for adaptive radiation\, and many have been shown to have important roles in development\, brain function\, cancer and other diseases. They function at many different levels of gene expression and cell biology\, including translational control\, formation of subcellular (phase-separated) domains\, and guidance of the epigenetic processes and chromatin dynamics that underpin development\, brain function and physiological adaptation\, with plasticity enabled by RNA editing\, RNA modification and retrotransposon mobilization. These discoveries mean that the assumption that combinatorial control by transcription factors and other regulatory proteins is sufficient to account for human ontogeny is incorrect\, as are the circular assumptions about the neutral evolution of the genome. The challenge now is to determine the structure-function relationships of these RNAs and their mechanisms of action\, as well as their place in the decisional hierarchies that control human development\, physiology\, learning and susceptibility to disorders
URL:https://rna.umich.edu/events/seminar-john-mattick/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201203T120000
DTEND;TZID=America/Detroit:20201203T130000
DTSTAMP:20260403T142004
CREATED:20201124T185141Z
LAST-MODIFIED:20201124T185320Z
UID:7518-1606996800-1607000400@rna.umich.edu
SUMMARY:U-M Life Sciences Institute Seminar Series:Astrid D. Haase\, M.D.\, Ph.D.\, NIH
DESCRIPTION:“A small RNA perspective on genomic conflict”\nAstrid D. Haase\, M.D.\, Ph.D.\, Stadtman Tenure-Track Investigator\, National Institute of Diabetes and Digestive and Kidney Diseases\, National Institutes of Health \nHosted by: Vivian Cheung\, M.D. \nZOOM
URL:https://rna.umich.edu/events/u-m-life-sciences-institute-seminar-series/
CATEGORIES:External Talks
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201202T160000
DTEND;TZID=America/Detroit:20201202T170000
DTSTAMP:20260403T142004
CREATED:20201014T173921Z
LAST-MODIFIED:20201014T174011Z
UID:7280-1606924800-1606928400@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - University of California\, Santa Cruz hosting
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-university-of-california-santa-cruz-hosting/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201118T160000
DTEND;TZID=America/Detroit:20201118T170000
DTSTAMP:20260403T142004
CREATED:20201014T173846Z
LAST-MODIFIED:20201014T173846Z
UID:7278-1605715200-1605718800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - Harvard Medical School Initiative for RNA Medicine hosting
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-harvard-medical-school-initiative-for-rna-medicine-hosting-2/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201116T160000
DTEND;TZID=America/Detroit:20201116T170000
DTSTAMP:20260403T142004
CREATED:20200819T182858Z
LAST-MODIFIED:20201105T193634Z
UID:6391-1605542400-1605546000@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Michelle Hastings\, Rosalind Franklin University
DESCRIPTION:“Splice-switching Antisense Oligonucleotides for the Treatment of Disease”\n\nMichelle Hastings\, Ph.D.\nProfessor\, Cell Biology and Anatomy; Director\, Center for Genetic Diseases\nRosalind Franklin University of Medicine and Science\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_VWX5SY6lSiaNyh5Weh8cHw \nSeminar flyer in PDF \n  \nABSTRACT: Antisense oligonucleotides (ASOs) have proven to be an effective therapeutic platform for the treatment of disease. These short\, single-stranded\, modified nucleotides function by base-pairing with the complementary sequence of an RNA and modulating gene expression in a manner that is dependent on the ASO design and targeting site. We have used ASOs to normalize aberrant gene expression associated with a number of diseases of the nervous system including Alzheimer’s and Parkinson’s disease and Usher syndrome. One of our approaches is under development for the treatment of CLN3 Batten disease\, a fatal\, pediatric lysosomal storage disease caused by mutations in a gene encoding the lysosomal membrane protein CLN3. The most common mutation associated with CLN3 Batten is a deletion of exons 7 and 8 (CLN3Δex78)\, which disrupts the mRNA open reading frame by creating a premature termination codon that results in the production of a truncated protein. We devised a therapeutic strategy for treating CLN3 Batten Disease using an ASO that basepairs to CLN3 pre-mRNA and alters splicing to correct the open reading frame of the mutated transcript. Treatment of CLN3Δex78 neonatal mice by intracerebroventricular injection of the ASO resulted in the desired splicing effect throughout the central nervous system\, improved motor deficits associated with the disease in mice\, reduced histopathological features of the disease in the brain and extended life in a severe mouse model of the disease. Our results demonstrate that ASO-mediated reading frame correction is a promising therapeutic approach for CLN3 Batten disease. \nKEYWORDS: pre-mRNA splicing\, Antisense oligonucleotides\, Usher syndrome\, Batten Disease\, lysosomal storage diseases
URL:https://rna.umich.edu/events/seminar-michelle-hastings-rosalind-franklin/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201104T160000
DTEND;TZID=America/Detroit:20201104T170000
DTSTAMP:20260403T142004
CREATED:20201014T173702Z
LAST-MODIFIED:20201014T173859Z
UID:7273-1604505600-1604509200@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - University of Rochester Center for RNA Biology hosting
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-university-of-rochester-center-for-rna-biology-hosting-2/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201026T090000
DTEND;TZID=America/Detroit:20201026T100000
DTSTAMP:20260403T142004
CREATED:20200818T122652Z
LAST-MODIFIED:20201022T131405Z
UID:6363-1603702800-1603706400@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Aleksandra Filipovska\, University of Western Australia
DESCRIPTION:Regulation of the mitochondrial transcriptome in health and disease\nAleksandra Filipovska\, Ph.D.\nProfessor\nThe University of Western Australia Centre for Medical Research\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_f8wC8rrJQzuhYzTEXoW69Q \nFLYER IN PDF \nAbstract:\nMitochondria produce more than 90% of the energy required by our bodies and thereby have a fundamental role in cell and energy metabolism. Mitochondria are composed of proteins encoded by both the nuclear and mitochondrial genomes and the coordinated expression of both genomes is essential for energy production. Impaired energy production leads to mitochondrial dysfunction that causes or contributes significantly to a variety of diseases including metabolic disorders and cardiovascular diseases. Mitochondrial dysfunction is caused by mutations in nuclear or mitochondrial genes that encode proteins or regulatory RNAs essential for mitochondrial biogenesis. How uncoordinated gene expression causes mitochondrial dysfunction and compromised energy production in heart and metabolic diseases is poorly understood\, making it difficult to develop effective treatments. To unravel how mitochondrial function fails and to identify therapeutic targets it is necessary (i) to understand how gene expression is regulated between mitochondria and the nucleus and (ii) how this regulation is disrupted in disease. We have created new and unique models of metabolic and cardiovascular diseases caused by mutations or loss of nuclear encoded RNA-binding proteins (RBPs) that regulate mitochondrial RNA metabolism and protein synthesis. These new models have identified that energy dysfunction can differentially affect specific organs such as the heart or liver\, or multiple organs leading to heart failure or metabolic diseases that can be devastating\, such as mitochondrial diseases\, or may be as common as insulin resistance and obesity. I will discuss the mechanisms behind these diverse pathologies caused by impaired gene expression and energy dysfunction in heart and metabolic disease. \nKeywords: mitochondria\, RNA\, ribosomes\, translation
URL:https://rna.umich.edu/events/seminar-aleksandra-filipovska-ph-d/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201021T160000
DTEND;TZID=America/Detroit:20201021T170000
DTSTAMP:20260403T142004
CREATED:20201007T175206Z
LAST-MODIFIED:20201014T173856Z
UID:7221-1603296000-1603299600@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - University of Pennsylvania RNA Group hosting
DESCRIPTION:Hosted by: University of Pennsylvania RNA Group \nKathy Fange Liu\, Ph.D.\n“RNA species dance to the beat of modifications” \nYoseph Barash\, Ph.D.\n“Splicing quantification from RNASeq – How to get the signal out of the noise?”\n \nModerator: Jeremy E Wilusz\, Ph.D. \nRecording of the session \nFor more information\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-university-of-pennsylvania-rna-group-hosting/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201019T160000
DTEND;TZID=America/Detroit:20201019T170000
DTSTAMP:20260403T142004
CREATED:20200818T123349Z
LAST-MODIFIED:20201005T115301Z
UID:6367-1603123200-1603126800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Gene Yeo\, University of California\, San Diego
DESCRIPTION:Systematic discovery of molecular and cellular functions of RNA binding proteins\nGene Yeo\, PhD\nProfessor\, Dept of Cellular and Molecular Medicine\, UCSD\nCo-Director\, UCSD Bioinformatics and Systems Biology Graduate Program\nUniversity of California\, San Diego\nInstitute for Genomic Medicine\nUCSD Stem Cell Program \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_CcI2trSATJy47aGtwrzhew \nFLYER IN PDF \nAbstract: The life-cycle of RNA from transcription to translational regulation is mediated by a diverse (>2000) set of proteins called RNA binding proteins. My lab studies the many roles that RNA binding proteins have in affecting RNA expression\, splicing\, transport and translation. Through our studies on RNA processing\, we have introduced therapeutic strategies to treat neurodegenerative and muscular diseases\, built cellular models of neurodevelopmental and neurodegenerative diseases and developed experimental and computational tools that enable the community to probe RNA binding protein-RNA interactions at scale. I will discuss (1) our established and new technologies to identify RNA targets of human RBPs at scale\, (2) systematic assays to assign molecular roles to RBPs and (2) functional screens to identify RBPs implicated in cancer / RNA granule formation.
URL:https://rna.umich.edu/events/seminar-gene-yeo-university-of-california-san-diego/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201007T160000
DTEND;TZID=America/Detroit:20201007T170000
DTSTAMP:20260403T142004
CREATED:20201007T174627Z
LAST-MODIFIED:20201007T174627Z
UID:7216-1602086400-1602090000@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - The RNA Institute\, University at Albany hosting
DESCRIPTION:Hosted by: The RNA Institute\, University at Albany \nJoseph Wade\, Ph.D. “Pervasive translation in Mycobacterium tuberculosis”\nScott Tenenbaum\, Ph.D.\, “sxRNA: The Engineering of trans-Acting 3-Way Junctions for Function” \nModerator: Thomas Begely\, Ph.D. \n \nLink: https://albany.zoom.us/j/92165416119?pwd=WWFaa3c3TmVIaDlEM0pVcEs2bmxmZz09  \nRecording of the session\nFor more information\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-the-rna-institute-university-at-albany-hosting/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201005T160000
DTEND;TZID=America/Detroit:20201005T170000
DTSTAMP:20260403T142004
CREATED:20200825T212746Z
LAST-MODIFIED:20201005T113331Z
UID:6459-1601913600-1601917200@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Chase Weidmann\, Washington University School of Medicine in St. Louis
DESCRIPTION:“Defining functional hubs in RNA-protein interaction networks”\n\nChase Weidmann\, Ph.D.\nPostdoctoral Research Scholar in the laboratory of Ben Major\nDepartment of Cell Biology & Physiology\, Washington University School of Medicine in St. Louis\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_y9HTFl5RSOSJTJ5qtlhVcw \nFLYER \nKeywords: mRNA regulation\, noncoding RNA\, RNA Structure\, RNP granules \nAbstract:\nChase Weidmann\, Ph.D. has contributed broadly to the field of RNA Biology during his career\, studying mechanisms of codon bias during translation\, post-transcriptional regulation of mRNAs by RNA-binding proteins\, the folding of long non-coding RNAs\, and how RNA-protein interaction networks contribute to the function and assembly of functional RNP particles. Chase developed a chemical probing strategy and next-gen sequencing technology\, called RNP-MaP\, that maps the location of and cooperation between multi-protein networks on RNAs in live cells. Going forward\, Chase is interested in understanding how alterations in RNA-binding protein profiles\, a cell’s “RBPome”\, confer deleterious activities onto noncoding RNAs in human disease\, especially in cancer. To further empower this work and his future research program\, Chase is now generating and integrating protein mass spectrometry data into his RBPome projects.
URL:https://rna.umich.edu/events/seminar-chase-weidmann-washington-university-school-of-medicine-in-st-louis/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20200929T120000
DTEND;TZID=America/Detroit:20200929T130000
DTSTAMP:20260403T142004
CREATED:20200922T164643Z
LAST-MODIFIED:20200922T165047Z
UID:6705-1601380800-1601384400@rna.umich.edu
SUMMARY:William EM Lands lecture featuring Jean Schaffer\, MD\, PhD\, Joslin Diabetes Center\, Harvard Medical School
DESCRIPTION:snoRNAs: Novel Links to Metabolism\n\nJean Schaffer\, MD\, PhD\nAssociate Research Director\nJoslin Diabetes Center\, Harvard Medical School\nflyer\n\n  \nDepartment of Biological Chemistry\, William EM Lands lecture
URL:https://rna.umich.edu/events/jean-schaffer/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20200928T090000
DTEND;TZID=America/Detroit:20200928T100000
DTSTAMP:20260403T142004
CREATED:20200817T170308Z
LAST-MODIFIED:20200922T163039Z
UID:6352-1601283600-1601287200@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Hiroaki Suga\, University of Tokyo
DESCRIPTION:“Genetic code reprogramming that Revolutionizes the discovery processes of peptide drug leads”\n\nHiroaki Suga\, PhD\nProfessor\, Department of Chemistry\, Graduate School of Science\nThe University of Tokyo\, Japan\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_PBHPayAvR8WobaSf3z0AUA \nABSTRACT: Macrocyclic peptides possess a number of pharmacological characteristics distinct from other well-established therapeutic molecular classes\, resulting in a versatile drug modality with a unique profile of advantages. Macrocyclic peptides are accessible by not only chemical synthesis but also ribosomal synthesis. Particularly\, recent inventions of the genetic code reprogramming integrated with an in vitro display format\, referred to as RaPID (Random non-standard Peptides Integrated Discovery) system\, have enabled us to screen mass libraries (>1 trillion members) of non-standard peptides containing multiple non-proteinogenic amino acids\, giving unique properties of peptides distinct from conventional peptides\, e.g. greater proteolytic stability\, higher affinity (low nM to sub nM dissociation constants similar to antibodies)\, and superior pharmacokinetics. The field is rapidly growing evidenced by increasing interests from industrial sectors\, including small start-ups as well as mega-pharmas\, toward drug development efforts on macrocyclic peptides\, which has led to several de novo discovered peptides entering clinical trials. This lecture discusses the aforementioned screening technology involving the method of “genetic code reprogramming” powered by flexizymes\, and several showcases of therapeutic potentials of macrocyclic peptides \nJoin us for a Journal club to prepare for Dr Suga’s seminar\nSeptember 24 @ 4:00 pm – 5:00 pm\nZOOM LINK: https://umich.zoom.us/j/93910966695\nPublication to review:“Ribosomal Formation of Thioamide Bonds in Polypeptide Synthesis” Rumit Maini\, Hiroyuki Kimura\, Ryo Takatsuji\, Takayuki Katoh\, Yuki Goto\, and Hiroaki Suga https://pubs.acs.org/doi/pdf/10.1021/jacs.9b11097 \nRESEARCH INTERESTS: In the Suga lab\, our aim is to utilize organic chemistry techniques in combination with biology to tackle yet unresolved questions. In our inclusive research\, we procure scientific knowledge leading to new concepts and develop novel technologies with broad applicability\, which can extend to drug discovery. We provide a diligent and cooperative research environment with a goal of nurturing individuals so they are brimming with innovation and global-mindedness. \n  \n  \n 
URL:https://rna.umich.edu/events/seminar-hiroaki-suga-university-of-tokyo/
CATEGORIES:Journal Club,Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20200923T080000
DTEND;TZID=America/Detroit:20200925T170000
DTSTAMP:20260403T142004
CREATED:20200717T112423Z
LAST-MODIFIED:20200717T134505Z
UID:6195-1600848000-1601053200@rna.umich.edu
SUMMARY:RiboClub Forum
DESCRIPTION:RiboClub FORUM\nRNA Biology and Technology –  The Current Pandemic and Beyond\n\nOver 35 RNA scientists from Canada\, the US and Europe\, come together in this two-day forum.\nAbstract submission deadline: August 1st\nRegistration deadline: September 1st\n\nMORE INFO
URL:https://rna.umich.edu/events/riboclub-forum/
LOCATION:Virtual
CATEGORIES:External Talks
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20200921T160000
DTEND;TZID=America/Detroit:20200921T170000
DTSTAMP:20260403T142004
CREATED:20200406T125600Z
LAST-MODIFIED:20200922T162702Z
UID:5139-1600704000-1600707600@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Andrey S. Krasilnikov\, PhD\, Penn State University
DESCRIPTION:“Structures of eukaryotic RNases MRP/P RNPs reveal RNA-driven protein remodeling”\nAndrey Krasilnikov\, Associate Professor of Biochemistry and Molecular Biology\, Center for RNA Biology\, Pennsylvania State University\n \nKeywords: Ribozymes\, RNase P\, RNase MRP\, ribonucleoprotein complexes\, RNA-driven protein remodelling \nZOOM \nREGISTRATION REQUIRED: \nhttps://umich.zoom.us/webinar/register/WN_obckKUCLT4mXI7kPskzc-Q \n  \n \nAbstract: Ribonuclease (RNase) P is a ribozyme-based catalytic ribonucleoprotein complex involved primarily in the maturation of tRNA in all three domains of life. In the course of evolution\, the size and complexity of RNase P grew as the catalytic RNA moiety recruited additional protein components. In eukaryotes\, the RNase P lineage has split\, giving rise to a related RNP enzyme called RNase MRP\, which shares multiple structural features (including most of the protein components) with the eukaryotic RNase P\, but has a distinct and non-overlapping specificity. \nWe report the recently solved cryo-EM structure of the 450 kDa yeast RNase MRP holoenzyme and compare it with the structure of its progenitor RNP\, RNase P. We show that\, surprisingly\, several of the proteins shared by RNase MRP and RNase P undergo RNA-driven structural remodeling\, allowing the same proteins to function in distinct structural contexts. This remodeling\, combined with altered peripheral RNA elements\, results in the functional diversification of the two closely related RNPs\, in spite of the structural conservation of the nearly identical catalytic cores\, demonstrating structural underpinnings of the acquisition of new functions by catalytic RNPs.
URL:https://rna.umich.edu/events/andrey-krasilnikov-penn-state/
LOCATION:Virtual
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20200909T160000
DTEND;TZID=America/Detroit:20200909T170000
DTSTAMP:20260403T142004
CREATED:20200824T133947Z
LAST-MODIFIED:20200831T144245Z
UID:6452-1599667200-1599670800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - U-M Center for RNA Biomedicine hosting
DESCRIPTION:Wednesday\, September 9\, 2020\, 4:00–5:00 pm ET\n\n\nHosted by: U-MCenter for RNA Biomedicine \n\n\nWe will hear from: \n\n\n\nSue Hammoud\, Ph.D. \nAssistant Professor of Human Genetics\n“Same Same Different: Single cell RNAseq identifies conserved and divergent features of mammalian spermatogenesis” \n\n~and~ \n\n\n\n\n\n\n\nJustin Colacino\, Ph.D.\nAssistant Professor of Environmental Health Sciences\n“Single cell transcriptomic profiling to understand breast stem cell heterogeneity in development and cancer disparities” \n\n  \nZOOM registration link \n\nRecording of the session\n\n\nThe RNA Collaborative seminar series goal is to cross-promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; NCI RNA Biology Initiative; RiboClub Sherbrooke; The RNA Institute\, University At Albany; UMass Medical School\, RNA Therapeutics Institute; University of Michigan Center for RNA Biomedicine; University of Rochester Center for RNA Biology; Yale Center for RNA Science and Medicine\, European Molecular Biology Laboratory (EMBL)\, Shanghai RNA Club\, The Bay Area RNA Club (BARC)\, UCSC Center for Molecular Biology of RNA\, and NUS-CSI Singapore RNA Biology Center\, Penn RNA Group\, University of Pennsylvania\, and Helmholtz Institute for RNA-based Infection Research. \n\n \n  \nRNA Collaborative
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-u-m-center-for-rna-biomedicine-hosting/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20200826T160000
DTEND;TZID=America/Detroit:20200826T170000
DTSTAMP:20260403T142004
CREATED:20200817T171111Z
LAST-MODIFIED:20200817T171141Z
UID:6358-1598457600-1598461200@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - Yale Center for RNA Science and Medicine hosting
DESCRIPTION:Wednesday\, August 26\, 2020\, 4:00–5:00 pm\n\n\nHosted by Yale Center for RNA Science and Medicine \n\n\nSiyuan (Steven) Wang\, Ph.D.  “Image-based spatial genomics and transcriptomics”\nJunjie Guo\, Ph.D. “RNA decay deficits cause neurodegeneration in ALS/FTD”\n\nZOOM link\n\nRecording of the session \n\nThe RNA Collaborative seminar series goal is to cross promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; NCI RNA Biology Initiative; RiboClub Sherbrooke; The RNA Institute\, University At Albany; UMass Medical School\, RNA Therapeutics Institute; University of Michigan Center for RNA Biomedicine; University of Rochester Center for RNA Biology; Yale Center for RNA Science and Medicine\, European Molecular Biology Laboratory (EMBL)\, Shanghai RNA Club\, The Bay Area RNA Club (BARC)\, UCSC Center for Molecular Biology of RNA\, and NUS-CSI Singapore RNA Biology Center.
URL:https://rna.umich.edu/events/6358/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20200812T160000
DTEND;TZID=America/Detroit:20200812T170000
DTSTAMP:20260403T142004
CREATED:20200521T150730Z
LAST-MODIFIED:20200720T145205Z
UID:5818-1597248000-1597251600@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - NIH NCI RNA Biology Initiative hosting
DESCRIPTION:Wednesday\, August 12\, 2020\, 4:00–5:00 pm\n\n\nHosted by NCI RNA Biology Initiative \n\n\nShuo Gu\, Ph.D.  “A tale of tails: How 3’ uridylation alters miRNA function”\nVoula Mili\, Ph.D. “Local co-translational interactions control protein function”\n\n\nRecording of the session \n\nThe RNA Collaborative seminar series goal is to cross promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; NCI RNA Biology Initiative; RiboClub Sherbrooke\, Québec; The RNA Institute\, University At Albany; UMass Medical School\, RNA Therapeutics Institute; University of Michigan Center for RNA Biomedicine;University of Rochester Center for RNA Biology; Yale Center for RNA Science and Medicine
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-nih-national-cancer-institute-hosting/
CATEGORIES:External Talks
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20200729T170000
DTEND;TZID=America/Detroit:20200729T170000
DTSTAMP:20260403T142004
CREATED:20200521T150553Z
LAST-MODIFIED:20200708T145959Z
UID:5816-1596042000-1596042000@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - Harvard Medical School Initiative for RNA Medicine hosting
DESCRIPTION:Wednesday\, July 29\, 2020\, 4:00–5:00 pm\n\n\nHosted by Harvard Medical School Initiative for RNA Medicine \n\nTim Yu\, MD\, PhD. “Prospects for hyper-individualized RNA medicines”\nShobha Vasudevan\, Ph.D. “A specialized post-transcriptional program in chemoresistant\, quiescent cancer cells”\nModerator: Frank Slack\, Ph.D.\n\nRecording of the session \nUpcoming seminars are available on the RNA Society’s new page: RNA Collaborative \n\nThe RNA Collaborative seminar series goal is to cross promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; RiboClub Sherbrooke\, Québec;The RNA Institute\, University At Albany;UMass Medical School\, RNA Therapeutics Institute;University of Michigan Center for RNA Biomedicine;University of Rochester Center for RNA Biology;Yale Center for RNA Science and Medicine
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-harvard-medical-school-initiative-for-rna-medicine-hosting/
CATEGORIES:External Talks
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20200715T160000
DTEND;TZID=America/Detroit:20200715T170000
DTSTAMP:20260403T142004
CREATED:20200521T150349Z
LAST-MODIFIED:20200708T145922Z
UID:5814-1594828800-1594832400@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - University of Rochester Center for RNA Biology
DESCRIPTION:Wednesday\, July 15\, 2020\, 4:00–5:00 pm\n\n\nHosted by University of Rochester Center for RNA Biology \n“Programmable RNA-targeting by CRISPR-Cas enzymes”\nMitch O’Connell\, Ph.D.\, Assistant Professor\, Department of Biochemistry & Biophysics; Member\, Center for RNA Biology \n“Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs”\nXin Li\, Ph.D.\, Associate Professor\, Departments of Biochemistry & Biophysics\, and Urology; Member\, Center for RNA Biology \n\n\nModerator: Lynne Maquat\, PhD \n\n\nRecording of the session \nUpcoming seminars are available on the RNA Society’s new page: RNA Collaborative \n\nThe RNA Collaborative seminar series goal is to cross promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; NCI RNA Biology Initiative; RiboClub Sherbrooke\, Québec; The RNA Institute\, University At Albany; UMass Medical School\, RNA Therapeutics Institute; University of Michigan Center for RNA Biomedicine;University of Rochester Center for RNA Biology; Yale Center for RNA Science and Medicine
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-university-of-rochester-center-for-rna-biology/
CATEGORIES:External Talks
END:VEVENT
END:VCALENDAR