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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210421T090000
DTEND;TZID=America/Detroit:20210421T100000
DTSTAMP:20260403T141521
CREATED:20210104T143404Z
LAST-MODIFIED:20210415T215048Z
UID:7659-1618995600-1618999200@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Shanghai RNA Club
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-tba-host-4/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210419T160000
DTEND;TZID=America/Detroit:20210419T170000
DTSTAMP:20260403T141521
CREATED:20210128T141644Z
LAST-MODIFIED:20210310T212447Z
UID:7864-1618848000-1618851600@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Jailson (Jay) Brito Querido\, MRC Laboratory of Molecular Biology
DESCRIPTION:“Structural insights into mRNA translation initiation in humans”\nJailson (Jay) Brito Querido\, Ph.D.\nPostdoctoral Scientist\nMRC Laboratory of Molecular Biology\nCambridge\, UK \nZOOM \nFLYER IN PDF \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_78YYOhIhTbOBy2_JSdM7Wg \nABSTRACT: A key step in translational initiation is the recruitment of the 43S pre-initiation complex (43S PIC) by the cap-binding complex (eIF4F) at the 5´ end of mRNA. Eukaryotic initiation factors eIF1\, eIF1A\, eIF3\, eIF5\, and the ternary complex (TC) of eIF2–GTP–tRNAiMet bind to the 40S ribosomal subunit to form the 43S PIC. Once assembled\, the 43S PIC is recruited to the cap-binding complex eIF4F at the 5´end of mRNA to form a 48S initiation complex (48S). The 48S then scans along the mRNA to locate a start codon. To understand the mechanisms involved\, we determined the structure of a reconstituted human 48S using cryo-electron microscopy. The structure reveals insights into early events of translation initiation complex assembly. It reveals how eIF4F interacts with subunits of the eIF3 structural core near the mRNA exit channel in the 43S. The location of eIF4F is consistent with a slotting model of mRNA recruitment and suggests a “blind-region” that would preclude recognition of start sites upstream of the location of the P site at the point of recruitment. \nKEYWORDS: mRNA\, ribosome\, eIF4F\, eIF4A\, translation
URL:https://rna.umich.edu/events/jay-querido/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210413T160000
DTEND;TZID=America/Detroit:20210413T170000
DTSTAMP:20260403T141521
CREATED:20210405T150818Z
LAST-MODIFIED:20210407T130407Z
UID:8417-1618329600-1618333200@rna.umich.edu
SUMMARY:Stephanie Moon\, Ph.D.\, "RNA regulation in proteotoxic stress and genetic neurological disorders"
DESCRIPTION:“RNA regulation in proteotoxic stress and genetic neurological disorders” \n\nStephanie Moon\, PhD\nAssistant Professor of Human Genetics\, a Faculty Scholar of the Center for RNA Biomedicine\, and an Affiliate Faculty of Biological Chemistry at the University of Michigan \nFaculty Host: Sundeep Kalantry\, PhD\, Associate Professor of Human Genetics \nZoom link: https://umich-health.zoom.us/j/92442599246 \nFLYER IN PDF \nCenter for Cell Plasticity and Organ Design Seminar
URL:https://rna.umich.edu/events/stephanie-moon/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210407T160000
DTEND;TZID=America/Detroit:20210407T170000
DTSTAMP:20260403T141521
CREATED:20210104T143303Z
LAST-MODIFIED:20210127T001017Z
UID:7657-1617811200-1617814800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Bay Area RNA Club (BARC)
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-host-bay-area-rna-club-barc/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210406T120000
DTEND;TZID=America/Detroit:20210406T130000
DTSTAMP:20260403T141521
CREATED:20200826T131104Z
LAST-MODIFIED:20210405T190959Z
UID:6468-1617710400-1617714000@rna.umich.edu
SUMMARY:Seminar: Eva Nogales\, Ludwig Lecture
DESCRIPTION:“Exploring the Modularity of Large Complexes Involved in Transcription Initiation and Chromatin Modifications” \n\nEva Nogales\, PhD\nHoward Hughes Medical Institute investigator\, Professor of Biochemistry and Molecular Biology\nUniversity of California\, Berkeley \nSenior Faculty Scientist\nLawrence Berkeley National Laboratory\n \nDepartment of Biological Chemistry\, Ludwig Lecture
URL:https://rna.umich.edu/events/seminar-eva-nogales-ludwig-lecture/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210405T160000
DTEND;TZID=America/Detroit:20210405T170000
DTSTAMP:20260403T141521
CREATED:20210126T233354Z
LAST-MODIFIED:20210310T173437Z
UID:7838-1617638400-1617642000@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Natoya Peart\, University of Pennsylvania
DESCRIPTION:“Direct binding of ESRP1 to regulated transcripts is required for position-dependent splicing regulation”\nNatoya Peart\, Ph.D.\nPostdoctoral Researcher – Carstens Lab/Lynch Lab\nDepartment of Medicine/Department of Biochemistry and Molecular Biophysics\nUniversity of Pennsylvania \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_0lUfePb0Qdac-cQZDpeiEQ \nFLYER IN PDF \nKEYWORDS: Alternative splicing\, RNAMap\, Esrp1 \nABSTRACT: Coordinated regulation of alternative splicing is essential to the establishment of cell identity. The Epithelial Splicing Regulatory Proteins (Esrps)\, ESRP1 and ESRP2\, are highly conserved paralogous proteins required for organogenesis of multiple organ systems and compromised function of Esrps contributes to human diseases and pathologies. Esrps are robustly expressed in the epithelial cells of the epidermis\, large and small intestines\, salivary glands\, stomach\, and a variety of other tissues\, where they are vital in promoting an epithelial splicing network. Although ESRP1 and ESRP2 share partial functional redundancy\, ESRP1 appears to play a larger role in regulating gene expression.\nUsing a combination of enhanced immunoprecipitation coupled with high throughput sequencing (eCLIP) in the epithelial cells of mouse epidermis and RNA sequencing analysis of alterations in splicing and total gene expression that result from epidermal ablation of Esrp1 and Esrp2 we generate a map of Esrp1 binding to RNA. We show that ESRP1 regulates splicing primarily through direct binding in a position-dependent manner to either promote exon inclusion or skipping. In particular\, we show that Esrp1 binding upstream of or withing alternatively spliced exons suppresses exon inclusion\, whilst binding downstream of the non-constitutive exon promotes exon inclusion. In addition\, we identified widespread binding of ESRP1 in 3’ and 5’ untranslated regions (UTRs) of genes enriched for epithelial cell function suggesting that it directly regulates post-transcriptional gene expression steps in addition to splicing.
URL:https://rna.umich.edu/events/natoya-peart/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210326T110000
DTEND;TZID=America/Detroit:20210326T143000
DTSTAMP:20260403T141521
CREATED:20210111T150420Z
LAST-MODIFIED:20210127T001342Z
UID:7706-1616756400-1616769000@rna.umich.edu
SUMMARY:5th Annual RNA Symposium: "Processing RNA" - Day 2
DESCRIPTION:Day 2\n11:00–11:05 / Welcome\n11:05–12:00 / Keynote 4: Brenda Bass\, Ph.D.\, University of Utah (RNA editing & silencing)\n12:00–12:10 / Short break\n12:10–1:05 / Keynote 5: Christopher Lima\, Ph.D.\, Memorial Sloan-Kettering (RNA degradation)\n1:05–1:35 / Data Blitz (three finalists from the poster submissions)\n1:35–2:25 / Panel discussion with keynote speakers\n2:25–2:30 / Closing \nREGISTRATION REQUIRED \nView full schedule here
URL:https://rna.umich.edu/events/5th-symposium-processing-rna-day-2/
CATEGORIES:Symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210325T110000
DTEND;TZID=America/Detroit:20210325T143000
DTSTAMP:20260403T141521
CREATED:20210111T150038Z
LAST-MODIFIED:20210127T001326Z
UID:7702-1616670000-1616682600@rna.umich.edu
SUMMARY:5th Annual RNA Symposium: "Processing RNA" - Day 1
DESCRIPTION:Day 1\n11:00–11:05 / Welcome\n11:05–12:00 / Keynote 1: Tracy Johnson\, Ph.D.\, University of California – Los Angeles (RNA splicing)\n12:00–12:10 / Short break\n12:10–1:05 / Keynote 2: Kevin Weeks\, Ph.D.\, University of North Carolina (RNA structure in vivo)\n1:05–1:35 / Data Blitz (three finalists from the poster submissions)\n1:35–2:30 / Keynote 3: Feng Zhang\, Ph.D.\, MIT (CRISPR applications)\n2:30–2:30 / Brief closing \nREGISTRATION REQUIRED \nView full schedule here
URL:https://rna.umich.edu/events/5th-symposium-processing-rna-day-1/
CATEGORIES:Symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210324T160000
DTEND;TZID=America/Detroit:20210324T170000
DTSTAMP:20260403T141521
CREATED:20201130T145224Z
LAST-MODIFIED:20210127T000917Z
UID:7536-1616601600-1616605200@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: UMass Medical School\, RNA Therapeutics Institute
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-umass-medical-school-rna-therapeutics-institute-hosting/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210315T160000
DTEND;TZID=America/Detroit:20210315T170000
DTSTAMP:20260403T141521
CREATED:20210126T231000Z
LAST-MODIFIED:20210209T190231Z
UID:7834-1615824000-1615827600@rna.umich.edu
SUMMARY:RNA Innovation Seminar: James Nuñez\, HHMI Hanna Gray Fellow\, UCSF
DESCRIPTION:“Programmable transcriptional memory by CRISPR-based epigenome editing”\nJames Nuñez\, Ph.D.\nHHMI Hanna Gray Fellow\nUniversity of California\, San Francisco \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_hZw_8jjWQo-7goOvohXOPg \nFLYER IN PDF \n \nABSTRACT: General approaches for heritably altering gene expression would enable many discovery and therapeutic efforts. I will present CRISPRoff— a programmable epigenetic memory writer consisting of a single dead Cas9 fusion protein that establishes DNA methylation and repressive histone modifications to turn off transcription. Transient CRISPRoff expression initiates highly specific DNA methylation and gene repression that is maintained through cell division and differentiation of stem cells to neurons. Pairing CRISPRoff with genome-wide screens and analysis of chromatin marks enabled us to explore the rules for heritable silencing. We identify sgRNAs capable of silencing the large majority of genes including those lacking canonical CpG islands (CGIs) and reveal a wide targeting window extending beyond annotated CGIs. Our finding that targeted DNA methylation outside of CGIs leads to memorized gene silencing expands the canonical model of methylation-based silencing and broadly enables diverse applications including genome-wide screens\, multiplexed cell engineering\, enhancer silencing\, and mechanistic exploration of epigenetic inheritance. \nKEYWORDS: CRISPR\, transcription\, epigenetics \n 
URL:https://rna.umich.edu/events/james-nunez/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210310T160000
DTEND;TZID=America/Detroit:20210310T170000
DTSTAMP:20260403T141521
CREATED:20201130T145136Z
LAST-MODIFIED:20210127T000841Z
UID:7534-1615392000-1615395600@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Alberta RNA Research and Training Institute (ARRTI)
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-tba-host-3/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210309T120000
DTEND;TZID=America/Detroit:20210309T130000
DTSTAMP:20260403T141521
CREATED:20200826T130623Z
LAST-MODIFIED:20210128T144524Z
UID:6463-1615291200-1615294800@rna.umich.edu
SUMMARY:BiolChem Seminar: Lori Passmore\, MRC Laboratory of Molecular Biology
DESCRIPTION:“Mechanistic Insights into the mRNA Poly(A) Tail Machinery”\n\nLori Passmore\, Ph.D.\nMRC Laboratory of Molecular Biology\n \n  \n  \nDepartment of Biological Chemistry\, Greenberg Lecture
URL:https://rna.umich.edu/events/seminar-lori-passmore-greenberg-lecture/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210303T160000
DTEND;TZID=America/Detroit:20210303T170000
DTSTAMP:20260403T141521
CREATED:20210126T184444Z
LAST-MODIFIED:20210210T165451Z
UID:7825-1614787200-1614790800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Melissa J. Moore - Chief Scientific Officer\, Moderna Therapeutics
DESCRIPTION:This event was rescheduled from February 10\, 4:00 pm.\nTo attend on March 3rd\, please register again. Apologies for the inconvenience.  \nZOOM REGISTRATION REQUIRED \n“A timely confluence: The backstory of Moderna’s COVID-19 vaccine”\n \n\nMelissa Moore\, Ph.D.\,\nChief Scientific Officer\, Moderna Therapeutics \nDr. Moore will address scientists and non-scientists\, and will take live questions.  \nFLYER IN PDF \nIn her role as Chief Scientific Officer\, Platform Research\, Dr. Melissa Moore is responsible for leading mRNA biology\, delivery and computation science research at Moderna. She joined Moderna in 2016 from the University of Massachusetts Medical School\, where she served as Professor of Biochemistry & Molecular Pharmacology\, Eleanor Eustis Farrington Chair in Cancer Research and a long-time Investigator at the Howard Hughes Medical Institute (HHMI).  Dr. Moore was also a founding Co-Director of the RNA Therapeutics Institute (RTI) at UMassMed\, and was instrumental in creating the Massachusetts Therapeutic and Entrepreneurship Realization initiative (MassTERi)\, a faculty-led program intended to facilitate the translation of UMMS discoveries into drugs\, products\, technologies and companies.  Dr. Moore is an elected member of the National Academy of Sciences (2017) and a Fellow of the American Academy of Arts and Sciences (2019). \nDr. Moore holds a B.S. in Chemistry and Biology from the College of William and Mary\, and a Ph.D. in Biological Chemistry from MIT\, where she specialized in enzymology under Prof. Christopher T. Walsh.  She began working on RNA metabolism during her postdoctoral training with Phillip A. Sharp at MIT.  During her 23 years as a faculty member\, first at Brandeis and then at UMassMed\, her research encompassed a broad array of topics related to the roles of RNA and RNA-protein (RNP) complexes in gene expression\, and touched on many human diseases including cancer\, neurodegeneration\, and preeclampsia.
URL:https://rna.umich.edu/events/melissa-moore/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210224T090000
DTEND;TZID=America/Detroit:20210224T100000
DTSTAMP:20260403T141521
CREATED:20201130T144849Z
LAST-MODIFIED:20210127T001234Z
UID:7528-1614157200-1614160800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Helmholtz Institute for RNA-based Infection Research
DESCRIPTION:Presenters:\nNeva Caliskan\, Ph.D.\nMathias Munschauer\, Ph.D.\nFor the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-helmholtz-institute-for-rna-based-infection-research-hosting/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210223T120000
DTEND;TZID=America/Detroit:20210223T130000
DTSTAMP:20260403T141521
CREATED:20210215T191752Z
LAST-MODIFIED:20210215T191857Z
UID:7988-1614081600-1614085200@rna.umich.edu
SUMMARY:BiolChem Seminar: Katrin Karbstein\, Scripps Institute Florida
DESCRIPTION:“Choreographing Ribosome Assembly”\n\nKatrin Karbstein\, Ph.D.\nScripps Institute Florida\n \nDepartment of Biological Chemistry\, Greenberg Lecture \nZoom link: https://umich.zoom.us/j/96151442305
URL:https://rna.umich.edu/events/katrin-karbstein/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210215T160000
DTEND;TZID=America/Detroit:20210215T170000
DTSTAMP:20260403T141521
CREATED:20201007T170749Z
LAST-MODIFIED:20210202T211040Z
UID:7212-1613404800-1613408400@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Karla Neugebauer\, Yale University
DESCRIPTION:“Dynamics of co-transcriptional pre-mRNA processing and assembly of related biomolecular condensates”\nProf. Karla Neugebauer\, Ph.D.\nProfessor of Molecular Biophysics and Biochemistry and of Cell Biology\nDirector of Graduate Studies\, Molecular Biophysics and Biochemistry\nDirector\, Yale Center for RNA Science and Medicine\nYale School of Medicine \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_aZggyZ0yQcSPcJrsHloXjQ \nFLYER IN PDF \nAbstract: My lab is interested in the coordination between transcription\, RNA processing and nuclear organization that governs gene expression. We have established experimental systems in budding yeast\, zebrafish embryos\, and mammalian tissue culture cells to explore transcription and splicing regulation in a variety of biological contexts and with a diversity of tools\, from imaging to genome-wide approaches. Our observations have provided novel insights into transcription and splicing mechanisms as well as principles of cellular organization that facilitate efficient gene expression. In this talk\, I will be discussing rapid co-transcriptional splicing during erythropoiesis and how Cajal bodies assemble to ensure a steady supply of spliceosomal components.
URL:https://rna.umich.edu/events/rna-innovation-seminar-karla-neugebauer/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210204T120000
DTEND;TZID=America/Detroit:20210204T130000
DTSTAMP:20260403T141521
CREATED:20201014T180836Z
LAST-MODIFIED:20210114T205907Z
UID:7290-1612440000-1612443600@rna.umich.edu
SUMMARY:LSI Seminar: Blanton S. Tolbert\, Ph.D.\, Case Western Reserve University
DESCRIPTION:Structural biophysics of RNA interactions that contribute to viral replication\nBlanton S. Tolbert\, Ph.D.\nProfessor of Chemistry\nCase Western Reserve University\n \nLSI Seminar Series \nInterests: Biochemistry\, Biophysical Chemistry\, Structural Biology \nBlanton S. Tolbert is a professor of chemistry at Case Western Reserve University\, where he oversees a diverse research group that endeavors to understand biochemical mechanisms by which human pathogenic RNA viruses replicate within cells\, and to leverage this knowledge to identify novel drug targets for therapeutic intervention. Tolbert is the PI of multiple NIH grants\, and he has published in top journals including Nature Communications\, the Proceedings of the National Academy of Sciences and the Journal of the American Chemical Society. Tolbert also serves on the NIH Office of AIDS Research Advisory Council (OARAC)\, and he will become the next chair of OARAC in 2021. He is a member of the Burroughs Wellcome Fund Postdoctoral Enrichment Program Advisory Board and an editor for the Journal of Biological Chemistry and Microbiology and Molecular Biology Reviews. Tolbert is the proud father of two boys\, and in his spare time he enjoys exploring the outdoors in the Cleveland Metroparks.
URL:https://rna.umich.edu/events/lsi-seminar-blanton-s-tolbert-ph-d-case-western-reserve-university/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210201T160000
DTEND;TZID=America/Detroit:20210201T170000
DTSTAMP:20260403T141521
CREATED:20200521T151621Z
LAST-MODIFIED:20210128T223131Z
UID:5820-1612195200-1612198800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Jeff Twiss\, University of South Carolina
DESCRIPTION:“Regulating the axonal proteome through mRNA transport and translation”\n\nJeffrey L. Twiss\, M.D.\, Ph.D.\nSmartState Chair in Childhood Neurotherapeutics\nProfessor of Biological Sciences\nUniversity of South Carolina\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_Rss4i-7WTwyf8m8ogCPXEQ \n  \n  \nFLYER IN PDF \nAbstract: Neurons are extremely polarized cells with axonal and dendritic processes extending 100 to 1000 fold longer or more than the cell body diameter. Our lab has been interested in how axons grow to such great distances and how they respond to injury. mRNAs are transported into axons\, with their localized translation providing the axon with autonomy to respond to different stimuli by modifying their local proteome. Transport\, translation\, and stability of axonal mRNAs is driven by interactions with RNA binding proteins and different signaling cascades. I will focus on recent work that gives insight into how specificity of these mechanisms is driven for different cohorts of axonal mRNAs. \nKeywords: Neuron\, Axon\, RNA transport\, Translational regulation
URL:https://rna.umich.edu/events/jeff-twiss/
LOCATION:Virtual
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210125T090000
DTEND;TZID=America/Detroit:20210125T100000
DTSTAMP:20260403T141521
CREATED:20200819T124758Z
LAST-MODIFIED:20210104T173802Z
UID:6382-1611565200-1611568800@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Elena Conti\, Max Planck Institute of Biochemistry
DESCRIPTION:Talk title: The RNA exosome complex: the Dr Jekyll and Mr Hyde of RNA degradation\nElena Conti\, PhD\nDirector\, Max Planck Institute of Biochemistry\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_IjnWw1UcRkW8zcDeuAM2tQ \n  \nFlyer in PDF \nKeywords: molecular mechanisms\, RNA\, ribosome\, biochemistry\, cryo-EM\, X-ray crystallography \nAbstract: All RNAs in eukaryotic cells are eventually degraded. The RNA exosome is a conserved macromolecular machine that degrades a vast number and variety of RNAs. Exosome-mediated RNA degradation leads to the complete elimination of nuclear and cytoplasmic transcripts in turnover and quality control pathways\, and to the partial trimming of RNA precursors in nuclear processing pathways. How the exosome combines specificity and versatility to either eliminate or process RNAs has been a long-standing question. \nOver the years\, our group has used biochemical and structural approaches to understand how the exosome core complex channels RNA substrates for degradation and how it associates with its nuclear and cytoplasmic cofactors. Visualizing how the exosome cofactors interact with pre-ribosomes in the nucleus and with mature ribosomes in the cytoplasm has provided insights into the mechanisms with which different exosome-ribosome assemblies underpin opposite outcomes of RNA degradation: a constructive function of the nuclear exosome in the maturation of the large ribosomal subunit and a destructive function of the cytoplasmic exosome in the destruction of ribosome-bound mRNAs. Ongoing work is uncovering the unanticipated levels of regulation intrinsic to this multi-purpose degradation machinery. \nOur group has a long-standing interest in RNA metabolism\, with a particular focus on the molecular mechanisms of eukaryotic RNA transport and degradation. >more
URL:https://rna.umich.edu/events/elena-conti-max-planck-institute-of-biochemistry/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210113T160000
DTEND;TZID=America/Detroit:20210113T170000
DTSTAMP:20260403T141521
CREATED:20201014T174252Z
LAST-MODIFIED:20201014T174404Z
UID:7287-1610553600-1610557200@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - NCI RNA Biology Initiative hosting
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-nci-rna-biology-initiative-hosting/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201216T090000
DTEND;TZID=America/Detroit:20201216T100000
DTSTAMP:20260403T141521
CREATED:20201014T174059Z
LAST-MODIFIED:20201014T174059Z
UID:7284-1608109200-1608112800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - European Molecular Biology Laboratory (EMBL) hosting
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-european-molecular-biology-laboratory-embl-hosting/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201214T160000
DTEND;TZID=America/Detroit:20201214T170000
DTSTAMP:20260403T141521
CREATED:20200818T125311Z
LAST-MODIFIED:20201202T175346Z
UID:6378-1607961600-1607965200@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Narry Kim\, Seoul National University
DESCRIPTION:“RNA-based regulation of viruses”\nNarry Kim\, PhD\nProfessor\, School of Biological Sciences\nSeoul National University\nFounding Director\, RNA Research Center\nInstitute for Basic Science\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_c9BFJM9dRGKn1WFF4L_wLg \nFLYER IN PDF \nAbstract: Viruses rely heavily on RNA binding proteins for their success as pathogens. In this presentation\, I will first talk about RNA tail modification which impacts viral and cellular gene expression. We found that TENT4 enzymes extend poly(A) tail of mRNAs with ‘mixed tails’ to delay deadenylation and stabilize the RNAs. Hepatitis B virus and human cytomegalovirus hijack this mechanism to efficiently stabilize their own RNAs. In the later part of my presentation\, I will discuss our recent work on SARS-CoV-2. To delineate the viral transcriptomic architecture and provide a high-resolution map of SARS-CoV-2\, we performed deep sequencing of infected cells. Our data define the canonical transcripts and noncanonical transcripts encoding unknown ORFs. More recently\, we have also performed proteomic analyses of the SARS-CoV-2 ribonucleoprotein complex. We identify many proteins that directly interact with viral RNAs and modulate viral growth. Functional investigation of the viral transcripts and host proteins discovered in this study will open new directions to the research efforts to elucidate the life cycle and pathogenicity of SARS-CoV-2. \n  \nBio: Narry Kim is a Professor in the School of Biological Sciences at Seoul National University and a founding director of RNA Research Center at Institute for Basic Science. She received her Ph.D. in 1998 from the University of Oxford where she studied lentiviruses and gene delivery. With keen interest in RNA biology\, she joined the Gideon Dreyfuss lab at the University of Pennsylvania and researched the role of the exon junction complex in mRNA surveillance. Her current research group investigates how genes are regulated at the RNA level\, with particular interests in microRNA\, mRNA\, and viral RNA. She is a recipient of the L’Oreal-UNESCO Women in Science Award\, Hoam Prize\, and Asan Prize\, and a member of KAS\, NAS and EMBO.
URL:https://rna.umich.edu/events/seminar-narry-kim-seoul-national-university/
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201207T170000
DTEND;TZID=America/Detroit:20201207T180000
DTSTAMP:20260403T141521
CREATED:20200818T124310Z
LAST-MODIFIED:20201201T223204Z
UID:6372-1607360400-1607364000@rna.umich.edu
SUMMARY:RNA Innovation Seminar: John Mattick\, University of New South Wales\, Sydney\, Australia
DESCRIPTION:RNA at the epicenter of cell and developmental biology\n\nJohn Mattick\, Ph.D.\nProfessor of RNA Biology\nSchool of Biotechnology and Biomolecular Sciences\nUniversity of New South Wales\, Sydney\, Australia\n\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_fCIiMkveTdq3D9-PKFLm6Q \nFLYER IN PDF \nABSTRACT: The genomic programming of the development of complex organisms appears to have been misunderstood. The human genome contains just ~20\,000 protein-coding genes\, similar in number and with largely orthologous functions as those in other animals\, including simple nematodes with only 1\,000 somatic cells. By contrast\, the extent of non-protein-coding DNA increases with increasing developmental complexity\, reaching 98.8% in humans. Moreover\, it is now clear that the majority of the genome is not junk but is differentially and dynamically transcribed to produce not only mRNAs but also tens if not hundreds of thousands of short and long non-protein-coding RNAs that show specific expression patterns and subcellular locations. Many of these noncoding RNAs have evolved rapidly under positive selection for adaptive radiation\, and many have been shown to have important roles in development\, brain function\, cancer and other diseases. They function at many different levels of gene expression and cell biology\, including translational control\, formation of subcellular (phase-separated) domains\, and guidance of the epigenetic processes and chromatin dynamics that underpin development\, brain function and physiological adaptation\, with plasticity enabled by RNA editing\, RNA modification and retrotransposon mobilization. These discoveries mean that the assumption that combinatorial control by transcription factors and other regulatory proteins is sufficient to account for human ontogeny is incorrect\, as are the circular assumptions about the neutral evolution of the genome. The challenge now is to determine the structure-function relationships of these RNAs and their mechanisms of action\, as well as their place in the decisional hierarchies that control human development\, physiology\, learning and susceptibility to disorders
URL:https://rna.umich.edu/events/seminar-john-mattick/
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201203T120000
DTEND;TZID=America/Detroit:20201203T130000
DTSTAMP:20260403T141521
CREATED:20201124T185141Z
LAST-MODIFIED:20201124T185320Z
UID:7518-1606996800-1607000400@rna.umich.edu
SUMMARY:U-M Life Sciences Institute Seminar Series:Astrid D. Haase\, M.D.\, Ph.D.\, NIH
DESCRIPTION:“A small RNA perspective on genomic conflict”\nAstrid D. Haase\, M.D.\, Ph.D.\, Stadtman Tenure-Track Investigator\, National Institute of Diabetes and Digestive and Kidney Diseases\, National Institutes of Health \nHosted by: Vivian Cheung\, M.D. \nZOOM
URL:https://rna.umich.edu/events/u-m-life-sciences-institute-seminar-series/
CATEGORIES:External Talks
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201202T160000
DTEND;TZID=America/Detroit:20201202T170000
DTSTAMP:20260403T141521
CREATED:20201014T173921Z
LAST-MODIFIED:20201014T174011Z
UID:7280-1606924800-1606928400@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - University of California\, Santa Cruz hosting
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-university-of-california-santa-cruz-hosting/
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201118T160000
DTEND;TZID=America/Detroit:20201118T170000
DTSTAMP:20260403T141521
CREATED:20201014T173846Z
LAST-MODIFIED:20201014T173846Z
UID:7278-1605715200-1605718800@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - Harvard Medical School Initiative for RNA Medicine hosting
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-harvard-medical-school-initiative-for-rna-medicine-hosting-2/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201116T160000
DTEND;TZID=America/Detroit:20201116T170000
DTSTAMP:20260403T141521
CREATED:20200819T182858Z
LAST-MODIFIED:20201105T193634Z
UID:6391-1605542400-1605546000@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Michelle Hastings\, Rosalind Franklin University
DESCRIPTION:“Splice-switching Antisense Oligonucleotides for the Treatment of Disease”\n\nMichelle Hastings\, Ph.D.\nProfessor\, Cell Biology and Anatomy; Director\, Center for Genetic Diseases\nRosalind Franklin University of Medicine and Science\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_VWX5SY6lSiaNyh5Weh8cHw \nSeminar flyer in PDF \n  \nABSTRACT: Antisense oligonucleotides (ASOs) have proven to be an effective therapeutic platform for the treatment of disease. These short\, single-stranded\, modified nucleotides function by base-pairing with the complementary sequence of an RNA and modulating gene expression in a manner that is dependent on the ASO design and targeting site. We have used ASOs to normalize aberrant gene expression associated with a number of diseases of the nervous system including Alzheimer’s and Parkinson’s disease and Usher syndrome. One of our approaches is under development for the treatment of CLN3 Batten disease\, a fatal\, pediatric lysosomal storage disease caused by mutations in a gene encoding the lysosomal membrane protein CLN3. The most common mutation associated with CLN3 Batten is a deletion of exons 7 and 8 (CLN3Δex78)\, which disrupts the mRNA open reading frame by creating a premature termination codon that results in the production of a truncated protein. We devised a therapeutic strategy for treating CLN3 Batten Disease using an ASO that basepairs to CLN3 pre-mRNA and alters splicing to correct the open reading frame of the mutated transcript. Treatment of CLN3Δex78 neonatal mice by intracerebroventricular injection of the ASO resulted in the desired splicing effect throughout the central nervous system\, improved motor deficits associated with the disease in mice\, reduced histopathological features of the disease in the brain and extended life in a severe mouse model of the disease. Our results demonstrate that ASO-mediated reading frame correction is a promising therapeutic approach for CLN3 Batten disease. \nKEYWORDS: pre-mRNA splicing\, Antisense oligonucleotides\, Usher syndrome\, Batten Disease\, lysosomal storage diseases
URL:https://rna.umich.edu/events/seminar-michelle-hastings-rosalind-franklin/
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201104T160000
DTEND;TZID=America/Detroit:20201104T170000
DTSTAMP:20260403T141521
CREATED:20201014T173702Z
LAST-MODIFIED:20201014T173859Z
UID:7273-1604505600-1604509200@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - University of Rochester Center for RNA Biology hosting
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-university-of-rochester-center-for-rna-biology-hosting-2/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201026T090000
DTEND;TZID=America/Detroit:20201026T100000
DTSTAMP:20260403T141521
CREATED:20200818T122652Z
LAST-MODIFIED:20201022T131405Z
UID:6363-1603702800-1603706400@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Aleksandra Filipovska\, University of Western Australia
DESCRIPTION:Regulation of the mitochondrial transcriptome in health and disease\nAleksandra Filipovska\, Ph.D.\nProfessor\nThe University of Western Australia Centre for Medical Research\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_f8wC8rrJQzuhYzTEXoW69Q \nFLYER IN PDF \nAbstract:\nMitochondria produce more than 90% of the energy required by our bodies and thereby have a fundamental role in cell and energy metabolism. Mitochondria are composed of proteins encoded by both the nuclear and mitochondrial genomes and the coordinated expression of both genomes is essential for energy production. Impaired energy production leads to mitochondrial dysfunction that causes or contributes significantly to a variety of diseases including metabolic disorders and cardiovascular diseases. Mitochondrial dysfunction is caused by mutations in nuclear or mitochondrial genes that encode proteins or regulatory RNAs essential for mitochondrial biogenesis. How uncoordinated gene expression causes mitochondrial dysfunction and compromised energy production in heart and metabolic diseases is poorly understood\, making it difficult to develop effective treatments. To unravel how mitochondrial function fails and to identify therapeutic targets it is necessary (i) to understand how gene expression is regulated between mitochondria and the nucleus and (ii) how this regulation is disrupted in disease. We have created new and unique models of metabolic and cardiovascular diseases caused by mutations or loss of nuclear encoded RNA-binding proteins (RBPs) that regulate mitochondrial RNA metabolism and protein synthesis. These new models have identified that energy dysfunction can differentially affect specific organs such as the heart or liver\, or multiple organs leading to heart failure or metabolic diseases that can be devastating\, such as mitochondrial diseases\, or may be as common as insulin resistance and obesity. I will discuss the mechanisms behind these diverse pathologies caused by impaired gene expression and energy dysfunction in heart and metabolic disease. \nKeywords: mitochondria\, RNA\, ribosomes\, translation
URL:https://rna.umich.edu/events/seminar-aleksandra-filipovska-ph-d/
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201021T160000
DTEND;TZID=America/Detroit:20201021T170000
DTSTAMP:20260403T141521
CREATED:20201007T175206Z
LAST-MODIFIED:20201014T173856Z
UID:7221-1603296000-1603299600@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series - University of Pennsylvania RNA Group hosting
DESCRIPTION:Hosted by: University of Pennsylvania RNA Group \nKathy Fange Liu\, Ph.D.\n“RNA species dance to the beat of modifications” \nYoseph Barash\, Ph.D.\n“Splicing quantification from RNASeq – How to get the signal out of the noise?”\n \nModerator: Jeremy E Wilusz\, Ph.D. \nRecording of the session \nFor more information\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-university-of-pennsylvania-rna-group-hosting/
CATEGORIES:Seminar
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