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SUMMARY:RNA Innovation Seminar: Connie Wu\, Ph.D.\, Research Assistant Professor\, Life Sciences Institute; Assistant Professor\, Biomedical Engineering and Pharmaceutical Sciences\, University of Michigan
DESCRIPTION:“Programming and probing the body: from RNA therapeutics to single-molecule detection”\nConnie Wu\, Ph.D.\nResearch Assistant Professor\,\nLife Sciences Institute\,\nAssistant Professor\,\nBiomedical Engineering and Pharmaceutical Sciences\,\nUniversity of Michigan\, U-M Medical School \nIn-person: ABC Seminar Rooms\, BSRB | Hybrid link \nAbstract:\nOur lab integrates biomolecular engineering and bioanalytical chemistry approaches to develop next-generation diagnostic and therapeutic platforms. I will first discuss our work in developing multifunctional RNA systems for cancer immunotherapy applications. Leveraging RNA as a programmable scaffold\, we engineer RNA nanostructures to activate multiple innate immune pathways and present additional immunomodulators. In parallel\, we develop ultrasensitive single-molecule detection platforms for diagnostic applications. While ultrasensitive digital ELISA methods have unlocked a broader spectrum of disease biomarkers\, achieving attomolar (10 -18 M) detection limits\, the simultaneous detection of many proteins and biomolecule types with high analytical sensitivities and throughput remains a critical challenge in biomarker signature discovery. Our ongoing efforts aim to expand the ultrasensitive single-molecule detection toolkit to enable accurate high-order multiplexing and multiparametric profiling of diverse biomarker types. \nBio:\nConnie Wu obtained her B.S. in chemical engineering from Yale University\, where she worked with Paul Van Tassel\, Ph.D.\, in designing porous layer-by-layer polymer films for tissue engineering applications. She pursued her Ph.D. in chemical engineering at MIT in the lab of Paula Hammond\, Ph.D.\, where she engineered a highly potent small interfering RNA (siRNA) nanoparticle delivery system via nucleic acid engineering and polymer chemistry approaches. \nFollowing her graduate studies\, Wu transitioned to the diagnostics field for her postdoctoral research in the lab of David Walt\, Ph.D.\, at Brigham and Women’s Hospital and the Wyss Institute at Harvard University\, where she pioneered ultrasensitive single-molecule detection methods that can measure attomolar protein concentrations with versatile multiplexing capabilities. In parallel\, she developed ultrasensitive digital assays for detecting the long interspersed element-1 (LINE-1) retrotransposon-encoded protein ORF1p in blood as a highly specific multi-cancer biomarker. \nWu was the recipient of multiple fellowships during her graduate and postdoctoral training\, including a National Science Foundation Graduate Research Fellowship\, MIT Presidential Fellowship and NIH Ruth L. Kirschstein F32 Postdoctoral Fellowship. \nAs part of the U-M Life Sciences Institute and the Department of Biomedical Engineering at the University of Michigan\, Wu’s lab develops technologies for biomarker signature discovery and RNA therapeutic delivery\, with applications across cancer and other diseases. \nLinks:\nConnie Wu Lab – Life Sciences Institute\nBiomedical Engineering\nCollege of Pharmacy\nUniversity of Michigan Medical School\n\nRNA Translated 2025 Feature Article
URL:https://rna.umich.edu/events/rna-innovation-seminar-connie-wu-ph-d-research-assistant-professor-life-sciences-institute-and-assistant-professor-departments-of-biomedical-engineering-and-pharmaceutical-sciences-university-o/
LOCATION:BSRB – ABC Seminar rooms\, 109 Zina Pitcher Pl\, Ann Arbor\, MI\, 48109\, United States
CATEGORIES:Seminar
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DTSTART;TZID=America/Detroit:20260420T160000
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DTSTAMP:20260502T052626
CREATED:20260413T153502Z
LAST-MODIFIED:20260420T153549Z
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SUMMARY:2026 Trainee RNA Seminar - Student-Postdoc Council
DESCRIPTION:We’re excited to invite you to the next 2026 Trainee RNA Seminar on Monday\, April 20 at 4:00 p.m. EDT. \n \nThis session will feature a chalk talk workshop presented by Dr. Rachel Niederer\, Assistant Professor of Biological Chemistry\, Medical School\, Biological Chemistry Dept.\, Faculty Scholar\, Center for RNA Biomedicine. \nDr. Niederer will present her chalk talk\, discuss approaches to developing effective and engaging chalk talks\, and conclude with time for audience questions. \n\nDate. Time. Location.\nMonday\, April 20th at 4:00 PM\nABC Seminar Rooms at BSRB. \nA Zoom option is also available. To join on Zoom\, please visit this link: https://umich.zoom.us/j/92875982672 \nTrainees are especially encouraged to participate. We look forward to seeing you there! \nCRB Student–Postdoc Council
URL:https://rna.umich.edu/events/2026-trainee-rna-seminar-student-postdoc-council/
LOCATION:BSRB – ABC Seminar rooms\, 109 Zina Pitcher Pl\, Ann Arbor\, MI\, 48109\, United States
CATEGORIES:Seminar
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DTSTART;TZID=America/Detroit:20260427T160000
DTEND;TZID=America/Detroit:20260427T170000
DTSTAMP:20260502T052626
CREATED:20260413T160318Z
LAST-MODIFIED:20260424T191100Z
UID:18561-1777305600-1777309200@rna.umich.edu
SUMMARY:Student-Postdoc Council Webinar with Eclipsebio
DESCRIPTION:The Center for RNA Biomedicine Student and Postdoc Council will be hosting a webinar featuring Dr. Wayne Doyle\, Director\, Platforms and Strategy\, Eclipsebio.\n\n\n\n\n\nSpeaker: Wayne Doyle\, Ph.D. Head of Scientific Platforms and Strategy\n \nTitle of the talk: “Sequencing-first solutions for RNA therapeutic development”\n\nTime: Apr 27\, 2026 04:00 PM Eastern Time \nJoin Zoom Meeting–\nhttps://umich.zoom.us/j/93314315337 \nMeeting ID: 933 1431 5337 \n\n\nAbstract:\n \n“Despite rapid advances in RNA medicine\, many programs fail due to poorly suboptimal designs and quality issues that conventional assays fail to detect. Addressing these challenges requires both effective design algorithms and advanced analytics that provide mechanistic insight into RNA therapeutic activity and safety.\n \nIn this seminar\, Dr. Wayne Doyle (Eclipsebio) will discuss how sequencing-based approaches reveal key insights for the development of siRNA and mRNA therapeutics. Key topics include multidimensional profiling of target RNAs\, AI-powered drug design\, and sequencing-based characterization of mRNA medicines.”\n\nJoin us!\n\nStudent-Postdoc Council
URL:https://rna.umich.edu/events/student-postdoc-council-webinar-with-eclipsebio/
CATEGORIES:Seminar
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