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DTSTAMP:20260502T065420
CREATED:20241223T181800Z
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SUMMARY:RNA Innovation Seminar: Sundeep Kalantry\, Ph.D.\, Professor of Human Genetics\, U-M Medical School
DESCRIPTION:“Evolution of Mammalian Dosage Compensation”\nSundeep Kalantry\, Ph.D.\nProfessor\,\nHuman Genetics\,\nUniversity of Michigan Medical School \n  \n  \nIn-person: Kahn Auditorium\, BSRB | Hybrid link \nAbstract:\nThe sex chromosomes pose an inequality between XX females and XY males. In therian mammals\, the Y chromosome contains few unique genes\, whereas the X chromosome harbors ~1000 protein-coding genes and many more noncoding loci. Excessive expression of X-linked genes in females can cause abnormal development and lethality. To equalize X-linked gene expression to that of males\, females evolved X-chromosome inactivation as a dosage compensation mechanism. X-inactivation results in the silencing of most genes on one of the two Xs in females. In eutherian (‘placental’) mammals\, X-inactivation requires the Xist long noncoding RNA that is expressed from and accumulates on the inactive X chromosome. Xist RNA recruits proteins that silence genes on the inactive-X. That dosage compensation requires X-inactivation and that X-inactivation requires the Xist RNA are tenets of mammalian sex chromosome biology. \nDespite much work\, however\, whether dosage compensation requires Xist RNA and X-inactivation remains unclear. Dosage compensation is believed to have originated in therian mammals when the Y chromosome differentiated from the X chromosome. To prevent loss of genes that favored male sexual differentiation\, discrete segments of the Y chromosome are thought to have undergone a series of inversions to suppress recombination with the X chromosome. Suppression of recombination is believed to have led to degeneration of genes on the Y chromosome. Due to the loss of Y-linked genes in males\, females are believed to have ultimately evolved X-inactivation as a dosage compensation mechanism. Since the Y chromosome lost its gene content gradually\, the need to dosage compensate X-linked genes is likely to also have arisen in a piecemeal manner. The step-wise differentiation of the X and Y chromosomes\, therefore\, is incompatible with chromosome-wide dosage compensation by Xist RNA and X-inactivation. \nHow dosage compensation can occur in the absence of Xist and X-inactivation is not known. The first Y chromosome segment to undergo differentiation from the X chromosome preceded the divergence of eutherian from metatherian mammals. Yet\, Xist evolved later and only in eutherians and not in metatherians. Dosage compensation of genes in this ancestral segment of the X chromosome\, therefore\, is likely to have occurred prior to the advent of Xist. The ancestral form of dosage compensation is unknown but we hypothesize is still functional. We further hypothesize that this ancestral mechanism of dosage compensation was subsequently co-opted to regulate Xist when Xist arose for chromosome-wide dosage compensation through X-inactivation. \nIn testing the above hypotheses\, we find that dosage compensation can occur in the absence of Xist and X- inactivation. We further identify an ancestral X-linked gene in the Xist- and X inactivation-independent dosage compensation mechanism. Together\, our data provide insights into the origins of sex differences\, mechanistically define the evolution of mammalian dosage compensation\, and broadly inform how cells balance gene expression despite changes in chromosome copy number.\n \nBio:\nOur long-standing focus is to understand mechanisms that underlie mammalian X chromosome dosage compensation\, including X chromosome inactivation. X-inactivation ensures similar levels of X-linked gene expression between female and male mammals by silencing genes on one of the two X chromosomes in females. Notably\, X-inactivation is also a model of sexually dimorphic epigenetic regulation\, since two identical X chromosomes in female cells become transcriptionally divergent.  The study of dosage compensation promises to elucidate the origins of sex differences and inform how cells balance gene expression despite changes in chromosome copy number \nLinks:\nKalantry Lab
URL:https://rna.umich.edu/events/rna-innovation-seminar-sundeep-kalantry-ph-d-professor-of-human-genetics-u-m-medical-school/
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20250409T160000
DTEND;TZID=America/Detroit:20250409T170000
DTSTAMP:20260502T065420
CREATED:20250403T182211Z
LAST-MODIFIED:20250407T192033Z
UID:16808-1744214400-1744218000@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series
DESCRIPTION:The next RNA Collaborative Seminar will be held virtually on Wednesday\, April 9th at 4 pm ET (Eastern\, US/Canada)\, hosted by the University of Rochester Center for RNA Biology & University of Michigan Center for RNA Biomedicine. Please see below for more details and the Zoom webinar registration link\, and share widely with your communities and networks. \nWednesday\, April 9th at 4 pm ET \nHosted by: University of Rochester Center for RNA Biology & University of Michigan Center for RNA Biomedicine\nZoom Registration: https://us02web.zoom.us/webinar/register/WN_QYg_EA_uSkK2CB987gltVA \n“Discovery and Therapeutic Applications of RNA ‘Stitching’” \nDoug Anderson\, PhD \nAssistant Professor of Medicine\, Cardiovascular Research Institute (CVRI)\nMember\, University of Rochester Center for RNA Biology: From Genome to Therapeutics \n“High-Throughput Identification of Small Molecule Inhibitors Targeting OncoMiR-181a for Cancer Therapy” \nGrace McIntyre\, PhD Student \nPhD Candidate\, Department of Pathology\, University of Michigan \n “Real-time Monitoring of Ligand Recognition by a Riboswitch during Transcription” \nAdrien Chauvier\, PhD. Research Lab Specialist \nNils Walter Laboratory – Department of Chemistry\, University of Michigan\nRNA Center for Biomedicine \nModerators: \nEric J. Wagner\, Ph.D.\nProfessor\, Department of Biochemistry and Biophysics\nAssociate Director\, Center for RNA Biology\nWilmot Cancer Institute\nUniversity of Rochester School of Medicine and Dentistry \nand \nNils G. Walter\, Ph.D.\nDirector\, Center for RNA Biomedicine; Francis S. Collins Collegiate Professor of Chemistry\, Biophysics\, and Biological Chemistry\, University of Michigan \nRNA Collaborative Seminars are sponsored by the RNA Society (@RNASociety) \nFor more information on the RNA CSS\, please visit: https://www.rnasociety.org/rna-collaborative-seminar-series \nRNA Collaborative YouTube: https://www.youtube.com/channel/UC7QawzQsUqhgIqjKGTny41A
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series/
LOCATION:Virtual
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/png:https://rna.umich.edu/wp-content/uploads/2025/04/RNA-Collaborative-Seminar.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20250428T160000
DTEND;TZID=America/Detroit:20250428T170000
DTSTAMP:20260502T065420
CREATED:20250409T131839Z
LAST-MODIFIED:20250410T182227Z
UID:16843-1745856000-1745859600@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Connie Wu\, Ph.D.\, Research Assistant Professor\, Life Sciences Institute; Assistant Professor\, Biomedical Engineering and Pharmaceutical Sciences\, University of Michigan
DESCRIPTION:“Programming and probing the body: from RNA therapeutics to single-molecule detection”\nConnie Wu\, Ph.D.\nResearch Assistant Professor\,\nLife Sciences Institute\,\nAssistant Professor\,\nBiomedical Engineering and Pharmaceutical Sciences\,\nUniversity of Michigan\, U-M Medical School \nIn-person: ABC Seminar Rooms\, BSRB | Hybrid link \nAbstract:\nOur lab integrates biomolecular engineering and bioanalytical chemistry approaches to develop next-generation diagnostic and therapeutic platforms. I will first discuss our work in developing multifunctional RNA systems for cancer immunotherapy applications. Leveraging RNA as a programmable scaffold\, we engineer RNA nanostructures to activate multiple innate immune pathways and present additional immunomodulators. In parallel\, we develop ultrasensitive single-molecule detection platforms for diagnostic applications. While ultrasensitive digital ELISA methods have unlocked a broader spectrum of disease biomarkers\, achieving attomolar (10 -18 M) detection limits\, the simultaneous detection of many proteins and biomolecule types with high analytical sensitivities and throughput remains a critical challenge in biomarker signature discovery. Our ongoing efforts aim to expand the ultrasensitive single-molecule detection toolkit to enable accurate high-order multiplexing and multiparametric profiling of diverse biomarker types. \nBio:\nConnie Wu obtained her B.S. in chemical engineering from Yale University\, where she worked with Paul Van Tassel\, Ph.D.\, in designing porous layer-by-layer polymer films for tissue engineering applications. She pursued her Ph.D. in chemical engineering at MIT in the lab of Paula Hammond\, Ph.D.\, where she engineered a highly potent small interfering RNA (siRNA) nanoparticle delivery system via nucleic acid engineering and polymer chemistry approaches. \nFollowing her graduate studies\, Wu transitioned to the diagnostics field for her postdoctoral research in the lab of David Walt\, Ph.D.\, at Brigham and Women’s Hospital and the Wyss Institute at Harvard University\, where she pioneered ultrasensitive single-molecule detection methods that can measure attomolar protein concentrations with versatile multiplexing capabilities. In parallel\, she developed ultrasensitive digital assays for detecting the long interspersed element-1 (LINE-1) retrotransposon-encoded protein ORF1p in blood as a highly specific multi-cancer biomarker. \nWu was the recipient of multiple fellowships during her graduate and postdoctoral training\, including a National Science Foundation Graduate Research Fellowship\, MIT Presidential Fellowship and NIH Ruth L. Kirschstein F32 Postdoctoral Fellowship. \nAs part of the U-M Life Sciences Institute and the Department of Biomedical Engineering at the University of Michigan\, Wu’s lab develops technologies for biomarker signature discovery and RNA therapeutic delivery\, with applications across cancer and other diseases. \nLinks:\nConnie Wu Lab – Life Sciences Institute\nBiomedical Engineering\nCollege of Pharmacy\nUniversity of Michigan Medical School\n\nRNA Translated 2025 Feature Article
URL:https://rna.umich.edu/events/rna-innovation-seminar-connie-wu-ph-d-research-assistant-professor-life-sciences-institute-and-assistant-professor-departments-of-biomedical-engineering-and-pharmaceutical-sciences-university-o/
LOCATION:BSRB – ABC Seminar rooms\, 109 Zina Pitcher Pl\, Ann Arbor\, MI\, 48109\, United States
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20260420T160000
DTEND;TZID=America/Detroit:20260420T170000
DTSTAMP:20260502T065420
CREATED:20260413T153502Z
LAST-MODIFIED:20260420T153549Z
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SUMMARY:2026 Trainee RNA Seminar - Student-Postdoc Council
DESCRIPTION:We’re excited to invite you to the next 2026 Trainee RNA Seminar on Monday\, April 20 at 4:00 p.m. EDT. \n \nThis session will feature a chalk talk workshop presented by Dr. Rachel Niederer\, Assistant Professor of Biological Chemistry\, Medical School\, Biological Chemistry Dept.\, Faculty Scholar\, Center for RNA Biomedicine. \nDr. Niederer will present her chalk talk\, discuss approaches to developing effective and engaging chalk talks\, and conclude with time for audience questions. \n\nDate. Time. Location.\nMonday\, April 20th at 4:00 PM\nABC Seminar Rooms at BSRB. \nA Zoom option is also available. To join on Zoom\, please visit this link: https://umich.zoom.us/j/92875982672 \nTrainees are especially encouraged to participate. We look forward to seeing you there! \nCRB Student–Postdoc Council
URL:https://rna.umich.edu/events/2026-trainee-rna-seminar-student-postdoc-council/
LOCATION:BSRB – ABC Seminar rooms\, 109 Zina Pitcher Pl\, Ann Arbor\, MI\, 48109\, United States
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20260427T160000
DTEND;TZID=America/Detroit:20260427T170000
DTSTAMP:20260502T065420
CREATED:20260413T160318Z
LAST-MODIFIED:20260424T191100Z
UID:18561-1777305600-1777309200@rna.umich.edu
SUMMARY:Student-Postdoc Council Webinar with Eclipsebio
DESCRIPTION:The Center for RNA Biomedicine Student and Postdoc Council will be hosting a webinar featuring Dr. Wayne Doyle\, Director\, Platforms and Strategy\, Eclipsebio.\n\n\n\n\n\nSpeaker: Wayne Doyle\, Ph.D. Head of Scientific Platforms and Strategy\n \nTitle of the talk: “Sequencing-first solutions for RNA therapeutic development”\n\nTime: Apr 27\, 2026 04:00 PM Eastern Time \nJoin Zoom Meeting–\nhttps://umich.zoom.us/j/93314315337 \nMeeting ID: 933 1431 5337 \n\n\nAbstract:\n \n“Despite rapid advances in RNA medicine\, many programs fail due to poorly suboptimal designs and quality issues that conventional assays fail to detect. Addressing these challenges requires both effective design algorithms and advanced analytics that provide mechanistic insight into RNA therapeutic activity and safety.\n \nIn this seminar\, Dr. Wayne Doyle (Eclipsebio) will discuss how sequencing-based approaches reveal key insights for the development of siRNA and mRNA therapeutics. Key topics include multidimensional profiling of target RNAs\, AI-powered drug design\, and sequencing-based characterization of mRNA medicines.”\n\nJoin us!\n\nStudent-Postdoc Council
URL:https://rna.umich.edu/events/student-postdoc-council-webinar-with-eclipsebio/
CATEGORIES:Seminar
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