BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Center for RNA Biomedicine - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Center for RNA Biomedicine
X-ORIGINAL-URL:https://rna.umich.edu
X-WR-CALDESC:Events for Center for RNA Biomedicine
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Detroit
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20210314T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20211107T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20220313T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20221106T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20230312T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20231105T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20240310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20241103T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20250309T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20251102T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20260308T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20261101T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20270314T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20271107T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20220321T150000
DTEND;TZID=America/Detroit:20220321T160000
DTSTAMP:20260502T031209
CREATED:20220314T142057Z
LAST-MODIFIED:20220314T183351Z
UID:10183-1647874800-1647878400@rna.umich.edu
SUMMARY:RNA Therapeutics Seminar\, Michelle Hastings\, Rosalind Franklin University
DESCRIPTION:Inaugural RNA Therapeutics Seminar\nMichelle Hastings\, Ph.D.\nProfessor\, Cell Biology and Anatomy; Director\, Center for Genetic Diseases\nRosalind Franklin University of Medicine and Science \n  \n  \n  \nThis is an internal U-M event:\nIn-person: Palmer Commons\, Forum Hall\nZoom: https://umich.zoom.us/webinar/register/WN_mUj40sudTwmI6hXANnlJEg \nKeywords: pre-mRNA splicing\, Antisense oligonucleotides\, Usher syndrome\, Batten Disease\, lysosomal storage diseases \nSeminar flyer in PDF \nIn-person COVID Events Policy
URL:https://rna.umich.edu/events/rna-therapeutics-seminar-michelle-hastings/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20220509T160000
DTEND;TZID=America/Detroit:20220509T170000
DTSTAMP:20260502T031209
CREATED:20211216T202325Z
LAST-MODIFIED:20220502T191433Z
UID:9963-1652112000-1652115600@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Sika Zheng\, UC Riverside\, School of Medicine
DESCRIPTION:“Unexpected determinants of neuronal identity and properties: the curious cases of PTBP1\, PTBP2\, and neuronal splicing”\nSika Zheng\, Ph.D. \nAssociate Professor\, Director of Center for RNA Biology and Medicine\nUC Riverside\, School of Medicine \n  \nFlyer in PDF \n  \nVirtual Seminar\nZoom: https://umich.zoom.us/webinar/register/WN_dltbxWdHQ5KrC3rTl4hqLQ \nAbstract:\nAlternative splicing is the major contributor to transcriptome diversity\, but splicing is noisy and to what extend alternative splicing regulation is indispensable for biolgical processes has been controversial. Our studies have revealed the regulation and function of neural-specific splicing in shaping neuronal identity and estalishing neurons’ two unique attributes: 1. Axonogenesis (Only neurons but no other cell types have one and single axon); 2. Neuronal longevity (Neurons are the most long-lived cell types). We show that obtaining these neuronal features is coordinated by RNA binding proteins PTBP1 and PTBP2\, while PTBP1 was suggested by others to be a reprogramming factor of neuronal fate. I will discuss the regulatory mechanism of neural specific splicing underlying neurogensis and maturation. \nReferences:\nZhang M\, Ergin V\, Lin L\, Stork C\, Chen L\, Zheng S. Neuron. 2019 Feb 20;101(4):690-706.e10.\nErgin V\, Zheng S. J Mol Biol. 2020 Jun 26;432(14):4154-4166.\nZheng S. Wiley Interdiscip Rev RNA. 2020 Jul;11(4):e1585.\nLin L\, Zhang M\, Stoilov P\, Chen L\, Zheng S. Neuron. 2020 Sep 23;107(6):1180-1196.e8.\nVuong J\, Ergin V\, Zheng S. Nature Communications (accepted)
URL:https://rna.umich.edu/events/sika-zheng/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20220516T160000
DTEND;TZID=America/Detroit:20220516T170000
DTSTAMP:20260502T031209
CREATED:20220218T163352Z
LAST-MODIFIED:20220506T161447Z
UID:10130-1652716800-1652720400@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Daniel O’Reilly
DESCRIPTION:“An Academic Approach to Oligonucleotide Therapeutics”\nDaniel O’Reilly Ph.D.\, MRSC\nPost-Doctoral Associate\nKhvorova Lab\nRNA Therapeutics Institute\nUniversity of Massachusetts Medical School \nFlyer in PDF \n  \nHYBRID SEMINAR:\nIn-person: BSRC\, ABC seminar rooms\nZoom: https://umich.zoom.us/webinar/register/WN_dM1a1aKVTM2KfwiieutOWg \nKeywords: Oligonucleotides\, Chemical Modifications\, RNA\, Huntington’s Disease \nAbstract: Nucleic acids (NA) are becoming the third major pillar of therapeutic modalities on par with small molecules and biologics. The diversity of NA molecular mechanisms\, ranging from vaccines\, antisense\, short interfering RNA (siRNAs)\, and guide RNA for CRISPR gene editing systems\, enable impact on most aspects of cellular biology and thus human medicine. The foundation behind the recent oligonucleotides’ clinical success is fundamental chemical innovations in RNA stability\, delivery\, and synthesis.\nOligonucleotides are informational drugs; thus\, if chemical architectures supporting safe and efficient delivery to the tissue of interest are achieved\, they can be easily reprogrammed to modulate any gene expression on demand\, creating an opportunity for academic institutions to drive therapeutic innovation. However\, the process is limited by access to oligonucleotide chemistry and synthetic expertise.\nIn the first half of the talk\, I will share the experience of building and running Nucleic Acid Chemistry Center in a context of a large academic institution. The NACC provides access to therapeutic quality screening leads and large manufacturing of preclinical compounds for the academic community. The impact of the NACC and chemical innovation will be discussed in the context of two significant projects. First\, I will discuss the systematic structure-activity relationship study of chemical modifications to modulate RISC loading and cleavage. Screening 1200 siRNA variants allow for defining the chemical and thermodynamic rules for RISC assembly.
URL:https://rna.umich.edu/events/daniel-oreilly/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20220912T160000
DTEND;TZID=America/Detroit:20220912T170000
DTSTAMP:20260502T031209
CREATED:20220826T123641Z
LAST-MODIFIED:20220829T141846Z
UID:10539-1662998400-1663002000@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Zhipeng Lu\, USC
DESCRIPTION:“RNA Structures\, Interactions and Modifications”\nZhipeng Lu (鲁志鹏)\, Ph.D.\nAssistant Professor\nPharmacology and Pharmaceutical Sciences\nUniversity of Southern California \n  \nFlyer in PDF \nIn-person: BSRB\, ABC seminar rooms / hybrid link \nAbstract: RNA in living cells are in constant motion\, form dynamic structures\, and interact with many molecules\, including other RNAs. Direct determination of RNA structures and interactions in vivo is essential to understanding their functions\, but has been challenging in the past. We developed a number of novel chemical and computational tools to capture the 2D and 3D RNA structurome and interactome in cells\, providing a comprehensive view of RNA conformations that underlie their roles in gene regulation and human diseases. Applications of these methods revealed new mechanisms in lncRNA functions\, RNA modifications and splicing regulation.
URL:https://rna.umich.edu/events/zhipeng-lu/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20220926T160000
DTEND;TZID=America/Detroit:20220926T170000
DTSTAMP:20260502T031209
CREATED:20220902T184752Z
LAST-MODIFIED:20220906T131746Z
UID:10554-1664208000-1664211600@rna.umich.edu
SUMMARY:RNA Innovation Seminar: David Shechner\, University of Washington
DESCRIPTION:“Meet the neighbors: A universal technology for probing RNA-interactions and RNA-scaffolded subcellular compartments in situ”\nDavid Shechner Ph.D.\nAssistant Professor of Pharmacology\nUniversity of Washington \n  \nFlyer in PDF \nIn-person: BSRB\, ABC seminar rooms / hybrid link \nKeywords: RNA\, proximity-biotinylation\, subcellular architecture\, nuclear architecture\, spatial biology\, biomolecular condensates\, interactomics\, nucleolus\, Xist. \n  \nAbstract: In the context of the living cell\, very little RNA is naked. RNA molecules form complex\, dynamic networks of molecular interactions that underlie a host of biochemical functions\, and which are central to organizing subcellular compartmentalization. In humans\, for example\, RNAs are key determinants of chromatin folding\, and they nucleate and scaffold a host of biomolecular condensates that collectively control cellular metabolic\, epigenetic\, and stress-signaling pathways. But\, characterizing these structures—identifying the biomolecules within an RNA’s subcellular microenvironment—remains technically cumbersome. \nTo address this challenge\, I introduce oligonucleotide-mediated proximity-interactome mapping (O-MAP)\, a straightforward and flexible method for identifying the proteins\, RNAs\, and genomic loci near a target RNA\, within its native cellular context. O-MAP uses programmable oligonucleotide probes to deliver proximity-biotinylating enzymes to a target RNA. These enzymes then pervasively label all nearby (~20 nm) molecules\, enabling their enrichment by streptavidin pulldown. O-MAP induces exceptionally precise RNA-targeted biotinylation\, and its modular design enables straightforward validation of probe pools and real-space optimization of the biotinylation radius\, thus overcoming key technical challenges for the field. Moreover\, O-MAP can be readily ported across different target RNAs and specimen types\, including patient-derived organoids and tissue samples. And\, O-MAP achieves this without complex cell-line engineering\, using only off-the-shelf parts and standard manipulations. \nUsing a small cohort of model RNAs\, we have developed a robust O-MAP toolkit for proteomic (O-MAP-MS)\, transcriptomic (O-MAP-Seq) and genome interaction (O-MAP-ChIP) discovery. O-MAP of the 47S-pre-rRNA—the long noncoding RNA that scaffolds the nucleolus—enabled a comprehensive “multi-omic” analysis of this subnuclear structure\, and revealed hundreds of novel nucleolar protein-\, RNA-\, and chromatin interactions. O-MAP of XIST—the master regulator of X-chromosome inactivation—revealed novel RNAs that may play a role in this process\, and unanticipated interactions between XIST and other chromatin-regulatory RNAs. Finally\, targeting O-MAP to introns within a key cardiac developmental gene enabled unprecedented molecular dissection of a subnuclear compartment that would be impossible to purify biochemically. \nGiven these results\, we believe that O-MAP will be a powerful tool for elucidating the mechanisms by which RNA molecules drive subcellular compartmentalization in time and space\, with particular impact on our understanding of nuclear architecture. Moreover\, with O-MAP’s precision\, flexibility\, and ease\, we anticipate its broad use in studying countless other RNA phenomena throughout biology\, and as a clinical diagnostic- and discovery tool.
URL:https://rna.umich.edu/events/david-shechner/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20221010T160000
DTEND;TZID=America/Detroit:20221010T170000
DTSTAMP:20260502T031209
CREATED:20220902T191232Z
LAST-MODIFIED:20220920T185235Z
UID:10559-1665417600-1665421200@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Polly Hsu\, Michigan State University
DESCRIPTION:“Roadblocks on mRNAs? Gene Expression Regulation by Upstream Open Reading Frames in Plants”\nPolly Hsu\, Ph.D.\nAssistant Professor\nBiochemistry and Molecular Biology\nMichigan State University \n  \n  \nFlyer in PDF \nIn-person: BSRB\, ABC seminar rooms / hybrid link \nKeywords: translation\, uORFs\, nonsense-mediated decay \nAbstract: 30-70% of mRNAs in humans\, mice and plants contain short ORFs\, called upstream ORFs (uORFs)\, in their 5’ leader sequences. The translation of uORFs is expected to repress the protein synthesis of their downstream main ORF (mORF) and to trigger mRNA degradation\, presumably through nonsense-mediated decay (NMD). I will share our current progress investigating the global and gene-specific mechanisms by which uORFs regulate gene expression in Arabidopsis and tomato. I will discuss 1) different classes of uORFs revealed by Ribo-seq\, 2) the roles of uORFs on transcription factor and protein kinase genes\, 3) the mRNA stability of uORF-containing genes\, and 4) cellular regulatory mechanisms to include or avoid uORFs on mRNA sequences.
URL:https://rna.umich.edu/events/polly-hsu/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20241007T160000
DTEND;TZID=America/Detroit:20241007T170000
DTSTAMP:20260502T031209
CREATED:20240927T142428Z
LAST-MODIFIED:20240927T150132Z
UID:15303-1728316800-1728320400@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Joseph Yesselman\, Ph.D. — University of Nebraska
DESCRIPTION:The University of Michigan Center for RNA Biomedicine Seminar Series will host Joseph Yesselman\, Ph.D.\, as part of the 2024 – 2025 RNA Innovation Seminar Series.\nJoseph Yesselman\, Ph.D.\nAssistant Professor\, Chemistry\nUniversity of Nebraska\n  \nDate and Time: Monday\, October 7 | 4 p.m.\nIn-person: Kahn Auditorium\, BSRB\nHybrid Option: Click here to join the Zoom.\n\nTalk Title: “High-throughput determination of RNA tertiary contact thermodynamics by quantitative DMS chemical mapping”\nAbstract:\nStructured RNAs often contain long-range tertiary contacts that are critical to their function. Despite the importance of tertiary contacts\, methods to measure their thermodynamics are low throughput or require specialized instruments. Here\, we introduce a new quantitative chemical mapping method (qMaPseq) to measure Mg2+-induced formation of tertiary contact thermodynamics in a high-throughput manner using standard biochemistry equipment. With qMaPseq\, we measured the ΔG of 98 unique tetraloop/tetraloop receptor (TL/TLR) variants in a one-pot reaction. These results agree well with measurements from specialized instruments (R2=0.64). Furthermore\, the DMS reactivity of the TL directly correlates to the stability of the contact (R2=0.68)\, the first direct evidence that a single DMS reactivity measurement reports on thermodynamics. Combined with structure prediction\, DMS reactivity allowed the development of experimentally accurate 3D models of TLR mutants.  These results demonstrate that qMaPseq is broadly accessible\, high-throughput\, and directly links DMS reactivity to thermodynamics. \nPlease visit the Yesselman Lab website to learn more about Dr. Yesselman and his work.
URL:https://rna.umich.edu/events/rna-innovation-seminar-joseph-yesselman-ph-d-university-of-nebraska/
LOCATION:BSRB – Kahn Auditorium
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20241021T160000
DTEND;TZID=America/Detroit:20241021T170000
DTSTAMP:20260502T031209
CREATED:20241009T165925Z
LAST-MODIFIED:20241015T191145Z
UID:15517-1729526400-1729530000@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Laura Scott\, Ph.D.\, University of Michigan School of Public Health
DESCRIPTION:“Regulation of RNA levels in muscle and adipose tissues by sex and genetic variants”\nLaura Scott\, Ph.D.\nResearch Professor\, Biostatistics\nUniversity of Michigan School of Public Health \nResearch interests:\nDr. Scott uses a combination of bulk and single nucleus omic data – RNA expression\, chromatin accessibility\, metabolites and DNA methylation – to understand the cellular genetic regulatory landscape and to infer biological connections between genetic variation and disease risk. \nClick here to read more about Dr. Scott and her work in a 2020 Faculty Spotlight article. \nIn-person: BSRB\, Kahn Auditorium / hybrid link\n \nAbstract:\nGene expression is regulated by multiple factors including genetic variation\, sex\, and cell type. I will describe differences by sex in human skeletal muscle cell type composition\, cell type-level gene expression and chromatin accessibility\, and bulk miRNA expression in 287 people. I will describe regulation of subcutaneous adipose gene expression by genetic variants in a meta-analysis of >2\,200 people. These studies help to better understand transcription and post-transcriptional regulation of gene expression by sex  and genetic regulation of gene expression.
URL:https://rna.umich.edu/events/rna-innovation-seminar-laura-scott-ph-d-university-of-michigan-school-of-public-health/
LOCATION:BSRB – Kahn Auditorium
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20250217T160000
DTEND;TZID=America/Detroit:20250217T160000
DTSTAMP:20260502T031209
CREATED:20241223T181800Z
LAST-MODIFIED:20250206T140005Z
UID:15974-1739808000-1739808000@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Sundeep Kalantry\, Ph.D.\, Professor of Human Genetics\, U-M Medical School
DESCRIPTION:“Evolution of Mammalian Dosage Compensation”\nSundeep Kalantry\, Ph.D.\nProfessor\,\nHuman Genetics\,\nUniversity of Michigan Medical School \n  \n  \nIn-person: Kahn Auditorium\, BSRB | Hybrid link \nAbstract:\nThe sex chromosomes pose an inequality between XX females and XY males. In therian mammals\, the Y chromosome contains few unique genes\, whereas the X chromosome harbors ~1000 protein-coding genes and many more noncoding loci. Excessive expression of X-linked genes in females can cause abnormal development and lethality. To equalize X-linked gene expression to that of males\, females evolved X-chromosome inactivation as a dosage compensation mechanism. X-inactivation results in the silencing of most genes on one of the two Xs in females. In eutherian (‘placental’) mammals\, X-inactivation requires the Xist long noncoding RNA that is expressed from and accumulates on the inactive X chromosome. Xist RNA recruits proteins that silence genes on the inactive-X. That dosage compensation requires X-inactivation and that X-inactivation requires the Xist RNA are tenets of mammalian sex chromosome biology. \nDespite much work\, however\, whether dosage compensation requires Xist RNA and X-inactivation remains unclear. Dosage compensation is believed to have originated in therian mammals when the Y chromosome differentiated from the X chromosome. To prevent loss of genes that favored male sexual differentiation\, discrete segments of the Y chromosome are thought to have undergone a series of inversions to suppress recombination with the X chromosome. Suppression of recombination is believed to have led to degeneration of genes on the Y chromosome. Due to the loss of Y-linked genes in males\, females are believed to have ultimately evolved X-inactivation as a dosage compensation mechanism. Since the Y chromosome lost its gene content gradually\, the need to dosage compensate X-linked genes is likely to also have arisen in a piecemeal manner. The step-wise differentiation of the X and Y chromosomes\, therefore\, is incompatible with chromosome-wide dosage compensation by Xist RNA and X-inactivation. \nHow dosage compensation can occur in the absence of Xist and X-inactivation is not known. The first Y chromosome segment to undergo differentiation from the X chromosome preceded the divergence of eutherian from metatherian mammals. Yet\, Xist evolved later and only in eutherians and not in metatherians. Dosage compensation of genes in this ancestral segment of the X chromosome\, therefore\, is likely to have occurred prior to the advent of Xist. The ancestral form of dosage compensation is unknown but we hypothesize is still functional. We further hypothesize that this ancestral mechanism of dosage compensation was subsequently co-opted to regulate Xist when Xist arose for chromosome-wide dosage compensation through X-inactivation. \nIn testing the above hypotheses\, we find that dosage compensation can occur in the absence of Xist and X- inactivation. We further identify an ancestral X-linked gene in the Xist- and X inactivation-independent dosage compensation mechanism. Together\, our data provide insights into the origins of sex differences\, mechanistically define the evolution of mammalian dosage compensation\, and broadly inform how cells balance gene expression despite changes in chromosome copy number.\n \nBio:\nOur long-standing focus is to understand mechanisms that underlie mammalian X chromosome dosage compensation\, including X chromosome inactivation. X-inactivation ensures similar levels of X-linked gene expression between female and male mammals by silencing genes on one of the two X chromosomes in females. Notably\, X-inactivation is also a model of sexually dimorphic epigenetic regulation\, since two identical X chromosomes in female cells become transcriptionally divergent.  The study of dosage compensation promises to elucidate the origins of sex differences and inform how cells balance gene expression despite changes in chromosome copy number \nLinks:\nKalantry Lab
URL:https://rna.umich.edu/events/rna-innovation-seminar-sundeep-kalantry-ph-d-professor-of-human-genetics-u-m-medical-school/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20250409T160000
DTEND;TZID=America/Detroit:20250409T170000
DTSTAMP:20260502T031209
CREATED:20250403T182211Z
LAST-MODIFIED:20250407T192033Z
UID:16808-1744214400-1744218000@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series
DESCRIPTION:The next RNA Collaborative Seminar will be held virtually on Wednesday\, April 9th at 4 pm ET (Eastern\, US/Canada)\, hosted by the University of Rochester Center for RNA Biology & University of Michigan Center for RNA Biomedicine. Please see below for more details and the Zoom webinar registration link\, and share widely with your communities and networks. \nWednesday\, April 9th at 4 pm ET \nHosted by: University of Rochester Center for RNA Biology & University of Michigan Center for RNA Biomedicine\nZoom Registration: https://us02web.zoom.us/webinar/register/WN_QYg_EA_uSkK2CB987gltVA \n“Discovery and Therapeutic Applications of RNA ‘Stitching’” \nDoug Anderson\, PhD \nAssistant Professor of Medicine\, Cardiovascular Research Institute (CVRI)\nMember\, University of Rochester Center for RNA Biology: From Genome to Therapeutics \n“High-Throughput Identification of Small Molecule Inhibitors Targeting OncoMiR-181a for Cancer Therapy” \nGrace McIntyre\, PhD Student \nPhD Candidate\, Department of Pathology\, University of Michigan \n “Real-time Monitoring of Ligand Recognition by a Riboswitch during Transcription” \nAdrien Chauvier\, PhD. Research Lab Specialist \nNils Walter Laboratory – Department of Chemistry\, University of Michigan\nRNA Center for Biomedicine \nModerators: \nEric J. Wagner\, Ph.D.\nProfessor\, Department of Biochemistry and Biophysics\nAssociate Director\, Center for RNA Biology\nWilmot Cancer Institute\nUniversity of Rochester School of Medicine and Dentistry \nand \nNils G. Walter\, Ph.D.\nDirector\, Center for RNA Biomedicine; Francis S. Collins Collegiate Professor of Chemistry\, Biophysics\, and Biological Chemistry\, University of Michigan \nRNA Collaborative Seminars are sponsored by the RNA Society (@RNASociety) \nFor more information on the RNA CSS\, please visit: https://www.rnasociety.org/rna-collaborative-seminar-series \nRNA Collaborative YouTube: https://www.youtube.com/channel/UC7QawzQsUqhgIqjKGTny41A
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series/
LOCATION:Virtual
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/png:https://rna.umich.edu/wp-content/uploads/2025/04/RNA-Collaborative-Seminar.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20250428T160000
DTEND;TZID=America/Detroit:20250428T170000
DTSTAMP:20260502T031209
CREATED:20250409T131839Z
LAST-MODIFIED:20250410T182227Z
UID:16843-1745856000-1745859600@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Connie Wu\, Ph.D.\, Research Assistant Professor\, Life Sciences Institute; Assistant Professor\, Biomedical Engineering and Pharmaceutical Sciences\, University of Michigan
DESCRIPTION:“Programming and probing the body: from RNA therapeutics to single-molecule detection”\nConnie Wu\, Ph.D.\nResearch Assistant Professor\,\nLife Sciences Institute\,\nAssistant Professor\,\nBiomedical Engineering and Pharmaceutical Sciences\,\nUniversity of Michigan\, U-M Medical School \nIn-person: ABC Seminar Rooms\, BSRB | Hybrid link \nAbstract:\nOur lab integrates biomolecular engineering and bioanalytical chemistry approaches to develop next-generation diagnostic and therapeutic platforms. I will first discuss our work in developing multifunctional RNA systems for cancer immunotherapy applications. Leveraging RNA as a programmable scaffold\, we engineer RNA nanostructures to activate multiple innate immune pathways and present additional immunomodulators. In parallel\, we develop ultrasensitive single-molecule detection platforms for diagnostic applications. While ultrasensitive digital ELISA methods have unlocked a broader spectrum of disease biomarkers\, achieving attomolar (10 -18 M) detection limits\, the simultaneous detection of many proteins and biomolecule types with high analytical sensitivities and throughput remains a critical challenge in biomarker signature discovery. Our ongoing efforts aim to expand the ultrasensitive single-molecule detection toolkit to enable accurate high-order multiplexing and multiparametric profiling of diverse biomarker types. \nBio:\nConnie Wu obtained her B.S. in chemical engineering from Yale University\, where she worked with Paul Van Tassel\, Ph.D.\, in designing porous layer-by-layer polymer films for tissue engineering applications. She pursued her Ph.D. in chemical engineering at MIT in the lab of Paula Hammond\, Ph.D.\, where she engineered a highly potent small interfering RNA (siRNA) nanoparticle delivery system via nucleic acid engineering and polymer chemistry approaches. \nFollowing her graduate studies\, Wu transitioned to the diagnostics field for her postdoctoral research in the lab of David Walt\, Ph.D.\, at Brigham and Women’s Hospital and the Wyss Institute at Harvard University\, where she pioneered ultrasensitive single-molecule detection methods that can measure attomolar protein concentrations with versatile multiplexing capabilities. In parallel\, she developed ultrasensitive digital assays for detecting the long interspersed element-1 (LINE-1) retrotransposon-encoded protein ORF1p in blood as a highly specific multi-cancer biomarker. \nWu was the recipient of multiple fellowships during her graduate and postdoctoral training\, including a National Science Foundation Graduate Research Fellowship\, MIT Presidential Fellowship and NIH Ruth L. Kirschstein F32 Postdoctoral Fellowship. \nAs part of the U-M Life Sciences Institute and the Department of Biomedical Engineering at the University of Michigan\, Wu’s lab develops technologies for biomarker signature discovery and RNA therapeutic delivery\, with applications across cancer and other diseases. \nLinks:\nConnie Wu Lab – Life Sciences Institute\nBiomedical Engineering\nCollege of Pharmacy\nUniversity of Michigan Medical School\n\nRNA Translated 2025 Feature Article
URL:https://rna.umich.edu/events/rna-innovation-seminar-connie-wu-ph-d-research-assistant-professor-life-sciences-institute-and-assistant-professor-departments-of-biomedical-engineering-and-pharmaceutical-sciences-university-o/
LOCATION:BSRB – ABC Seminar rooms\, 109 Zina Pitcher Pl\, Ann Arbor\, MI\, 48109\, United States
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20260420T160000
DTEND;TZID=America/Detroit:20260420T170000
DTSTAMP:20260502T031209
CREATED:20260413T153502Z
LAST-MODIFIED:20260420T153549Z
UID:18551-1776700800-1776704400@rna.umich.edu
SUMMARY:2026 Trainee RNA Seminar - Student-Postdoc Council
DESCRIPTION:We’re excited to invite you to the next 2026 Trainee RNA Seminar on Monday\, April 20 at 4:00 p.m. EDT. \n \nThis session will feature a chalk talk workshop presented by Dr. Rachel Niederer\, Assistant Professor of Biological Chemistry\, Medical School\, Biological Chemistry Dept.\, Faculty Scholar\, Center for RNA Biomedicine. \nDr. Niederer will present her chalk talk\, discuss approaches to developing effective and engaging chalk talks\, and conclude with time for audience questions. \n\nDate. Time. Location.\nMonday\, April 20th at 4:00 PM\nABC Seminar Rooms at BSRB. \nA Zoom option is also available. To join on Zoom\, please visit this link: https://umich.zoom.us/j/92875982672 \nTrainees are especially encouraged to participate. We look forward to seeing you there! \nCRB Student–Postdoc Council
URL:https://rna.umich.edu/events/2026-trainee-rna-seminar-student-postdoc-council/
LOCATION:BSRB – ABC Seminar rooms\, 109 Zina Pitcher Pl\, Ann Arbor\, MI\, 48109\, United States
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20260427T160000
DTEND;TZID=America/Detroit:20260427T170000
DTSTAMP:20260502T031209
CREATED:20260413T160318Z
LAST-MODIFIED:20260424T191100Z
UID:18561-1777305600-1777309200@rna.umich.edu
SUMMARY:Student-Postdoc Council Webinar with Eclipsebio
DESCRIPTION:The Center for RNA Biomedicine Student and Postdoc Council will be hosting a webinar featuring Dr. Wayne Doyle\, Director\, Platforms and Strategy\, Eclipsebio.\n\n\n\n\n\nSpeaker: Wayne Doyle\, Ph.D. Head of Scientific Platforms and Strategy\n \nTitle of the talk: “Sequencing-first solutions for RNA therapeutic development”\n\nTime: Apr 27\, 2026 04:00 PM Eastern Time \nJoin Zoom Meeting–\nhttps://umich.zoom.us/j/93314315337 \nMeeting ID: 933 1431 5337 \n\n\nAbstract:\n \n“Despite rapid advances in RNA medicine\, many programs fail due to poorly suboptimal designs and quality issues that conventional assays fail to detect. Addressing these challenges requires both effective design algorithms and advanced analytics that provide mechanistic insight into RNA therapeutic activity and safety.\n \nIn this seminar\, Dr. Wayne Doyle (Eclipsebio) will discuss how sequencing-based approaches reveal key insights for the development of siRNA and mRNA therapeutics. Key topics include multidimensional profiling of target RNAs\, AI-powered drug design\, and sequencing-based characterization of mRNA medicines.”\n\nJoin us!\n\nStudent-Postdoc Council
URL:https://rna.umich.edu/events/student-postdoc-council-webinar-with-eclipsebio/
CATEGORIES:Seminar
END:VEVENT
END:VCALENDAR