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DTSTART;TZID=America/Detroit:20241007T160000
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UID:15303-1728316800-1728320400@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Joseph Yesselman\, Ph.D. — University of Nebraska
DESCRIPTION:The University of Michigan Center for RNA Biomedicine Seminar Series will host Joseph Yesselman\, Ph.D.\, as part of the 2024 – 2025 RNA Innovation Seminar Series.\nJoseph Yesselman\, Ph.D.\nAssistant Professor\, Chemistry\nUniversity of Nebraska\n  \nDate and Time: Monday\, October 7 | 4 p.m.\nIn-person: Kahn Auditorium\, BSRB\nHybrid Option: Click here to join the Zoom.\n\nTalk Title: “High-throughput determination of RNA tertiary contact thermodynamics by quantitative DMS chemical mapping”\nAbstract:\nStructured RNAs often contain long-range tertiary contacts that are critical to their function. Despite the importance of tertiary contacts\, methods to measure their thermodynamics are low throughput or require specialized instruments. Here\, we introduce a new quantitative chemical mapping method (qMaPseq) to measure Mg2+-induced formation of tertiary contact thermodynamics in a high-throughput manner using standard biochemistry equipment. With qMaPseq\, we measured the ΔG of 98 unique tetraloop/tetraloop receptor (TL/TLR) variants in a one-pot reaction. These results agree well with measurements from specialized instruments (R2=0.64). Furthermore\, the DMS reactivity of the TL directly correlates to the stability of the contact (R2=0.68)\, the first direct evidence that a single DMS reactivity measurement reports on thermodynamics. Combined with structure prediction\, DMS reactivity allowed the development of experimentally accurate 3D models of TLR mutants.  These results demonstrate that qMaPseq is broadly accessible\, high-throughput\, and directly links DMS reactivity to thermodynamics. \nPlease visit the Yesselman Lab website to learn more about Dr. Yesselman and his work.
URL:https://rna.umich.edu/events/rna-innovation-seminar-joseph-yesselman-ph-d-university-of-nebraska/
LOCATION:BSRB – Kahn Auditorium
CATEGORIES:Seminar
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DTSTART;TZID=America/Detroit:20241021T160000
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DTSTAMP:20260429T050142
CREATED:20241009T165925Z
LAST-MODIFIED:20241015T191145Z
UID:15517-1729526400-1729530000@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Laura Scott\, Ph.D.\, University of Michigan School of Public Health
DESCRIPTION:“Regulation of RNA levels in muscle and adipose tissues by sex and genetic variants”\nLaura Scott\, Ph.D.\nResearch Professor\, Biostatistics\nUniversity of Michigan School of Public Health \nResearch interests:\nDr. Scott uses a combination of bulk and single nucleus omic data – RNA expression\, chromatin accessibility\, metabolites and DNA methylation – to understand the cellular genetic regulatory landscape and to infer biological connections between genetic variation and disease risk. \nClick here to read more about Dr. Scott and her work in a 2020 Faculty Spotlight article. \nIn-person: BSRB\, Kahn Auditorium / hybrid link\n \nAbstract:\nGene expression is regulated by multiple factors including genetic variation\, sex\, and cell type. I will describe differences by sex in human skeletal muscle cell type composition\, cell type-level gene expression and chromatin accessibility\, and bulk miRNA expression in 287 people. I will describe regulation of subcutaneous adipose gene expression by genetic variants in a meta-analysis of >2\,200 people. These studies help to better understand transcription and post-transcriptional regulation of gene expression by sex  and genetic regulation of gene expression.
URL:https://rna.umich.edu/events/rna-innovation-seminar-laura-scott-ph-d-university-of-michigan-school-of-public-health/
LOCATION:BSRB – Kahn Auditorium
CATEGORIES:Seminar
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