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X-WR-CALDESC:Events for Center for RNA Biomedicine
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DTSTART;TZID=America/Detroit:20210303T160000
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DTSTAMP:20260504T072131
CREATED:20210126T184444Z
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SUMMARY:RNA Innovation Seminar: Melissa J. Moore - Chief Scientific Officer\, Moderna Therapeutics
DESCRIPTION:This event was rescheduled from February 10\, 4:00 pm.\nTo attend on March 3rd\, please register again. Apologies for the inconvenience.  \nZOOM REGISTRATION REQUIRED \n“A timely confluence: The backstory of Moderna’s COVID-19 vaccine”\n \n\nMelissa Moore\, Ph.D.\,\nChief Scientific Officer\, Moderna Therapeutics \nDr. Moore will address scientists and non-scientists\, and will take live questions.  \nFLYER IN PDF \nIn her role as Chief Scientific Officer\, Platform Research\, Dr. Melissa Moore is responsible for leading mRNA biology\, delivery and computation science research at Moderna. She joined Moderna in 2016 from the University of Massachusetts Medical School\, where she served as Professor of Biochemistry & Molecular Pharmacology\, Eleanor Eustis Farrington Chair in Cancer Research and a long-time Investigator at the Howard Hughes Medical Institute (HHMI).  Dr. Moore was also a founding Co-Director of the RNA Therapeutics Institute (RTI) at UMassMed\, and was instrumental in creating the Massachusetts Therapeutic and Entrepreneurship Realization initiative (MassTERi)\, a faculty-led program intended to facilitate the translation of UMMS discoveries into drugs\, products\, technologies and companies.  Dr. Moore is an elected member of the National Academy of Sciences (2017) and a Fellow of the American Academy of Arts and Sciences (2019). \nDr. Moore holds a B.S. in Chemistry and Biology from the College of William and Mary\, and a Ph.D. in Biological Chemistry from MIT\, where she specialized in enzymology under Prof. Christopher T. Walsh.  She began working on RNA metabolism during her postdoctoral training with Phillip A. Sharp at MIT.  During her 23 years as a faculty member\, first at Brandeis and then at UMassMed\, her research encompassed a broad array of topics related to the roles of RNA and RNA-protein (RNP) complexes in gene expression\, and touched on many human diseases including cancer\, neurodegeneration\, and preeclampsia.
URL:https://rna.umich.edu/events/melissa-moore/
CATEGORIES:Seminar
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DTSTART;TZID=America/Detroit:20210309T120000
DTEND;TZID=America/Detroit:20210309T130000
DTSTAMP:20260504T072131
CREATED:20200826T130623Z
LAST-MODIFIED:20210128T144524Z
UID:6463-1615291200-1615294800@rna.umich.edu
SUMMARY:BiolChem Seminar: Lori Passmore\, MRC Laboratory of Molecular Biology
DESCRIPTION:“Mechanistic Insights into the mRNA Poly(A) Tail Machinery”\n\nLori Passmore\, Ph.D.\nMRC Laboratory of Molecular Biology\n \n  \n  \nDepartment of Biological Chemistry\, Greenberg Lecture
URL:https://rna.umich.edu/events/seminar-lori-passmore-greenberg-lecture/
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210310T160000
DTEND;TZID=America/Detroit:20210310T170000
DTSTAMP:20260504T072131
CREATED:20201130T145136Z
LAST-MODIFIED:20210127T000841Z
UID:7534-1615392000-1615395600@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: Alberta RNA Research and Training Institute (ARRTI)
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-tba-host-3/
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210315T160000
DTEND;TZID=America/Detroit:20210315T170000
DTSTAMP:20260504T072131
CREATED:20210126T231000Z
LAST-MODIFIED:20210209T190231Z
UID:7834-1615824000-1615827600@rna.umich.edu
SUMMARY:RNA Innovation Seminar: James Nuñez\, HHMI Hanna Gray Fellow\, UCSF
DESCRIPTION:“Programmable transcriptional memory by CRISPR-based epigenome editing”\nJames Nuñez\, Ph.D.\nHHMI Hanna Gray Fellow\nUniversity of California\, San Francisco \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_hZw_8jjWQo-7goOvohXOPg \nFLYER IN PDF \n \nABSTRACT: General approaches for heritably altering gene expression would enable many discovery and therapeutic efforts. I will present CRISPRoff— a programmable epigenetic memory writer consisting of a single dead Cas9 fusion protein that establishes DNA methylation and repressive histone modifications to turn off transcription. Transient CRISPRoff expression initiates highly specific DNA methylation and gene repression that is maintained through cell division and differentiation of stem cells to neurons. Pairing CRISPRoff with genome-wide screens and analysis of chromatin marks enabled us to explore the rules for heritable silencing. We identify sgRNAs capable of silencing the large majority of genes including those lacking canonical CpG islands (CGIs) and reveal a wide targeting window extending beyond annotated CGIs. Our finding that targeted DNA methylation outside of CGIs leads to memorized gene silencing expands the canonical model of methylation-based silencing and broadly enables diverse applications including genome-wide screens\, multiplexed cell engineering\, enhancer silencing\, and mechanistic exploration of epigenetic inheritance. \nKEYWORDS: CRISPR\, transcription\, epigenetics \n 
URL:https://rna.umich.edu/events/james-nunez/
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20210324T160000
DTEND;TZID=America/Detroit:20210324T170000
DTSTAMP:20260504T072131
CREATED:20201130T145224Z
LAST-MODIFIED:20210127T000917Z
UID:7536-1616601600-1616605200@rna.umich.edu
SUMMARY:RNA Collaborative Seminar Series // Host: UMass Medical School\, RNA Therapeutics Institute
DESCRIPTION:For the seminar details\, visit: https://www.rnasociety.org/rna-collaborative-seminar-series
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-umass-medical-school-rna-therapeutics-institute-hosting/
CATEGORIES:Seminar
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