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X-WR-CALDESC:Events for Center for RNA Biomedicine
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DTSTART;TZID=America/Detroit:20200909T160000
DTEND;TZID=America/Detroit:20200909T170000
DTSTAMP:20260504T143903
CREATED:20200824T133947Z
LAST-MODIFIED:20200831T144245Z
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SUMMARY:RNA Collaborative Seminar Series - U-M Center for RNA Biomedicine hosting
DESCRIPTION:Wednesday\, September 9\, 2020\, 4:00–5:00 pm ET\n\n\nHosted by: U-MCenter for RNA Biomedicine \n\n\nWe will hear from: \n\n\n\nSue Hammoud\, Ph.D. \nAssistant Professor of Human Genetics\n“Same Same Different: Single cell RNAseq identifies conserved and divergent features of mammalian spermatogenesis” \n\n~and~ \n\n\n\n\n\n\n\nJustin Colacino\, Ph.D.\nAssistant Professor of Environmental Health Sciences\n“Single cell transcriptomic profiling to understand breast stem cell heterogeneity in development and cancer disparities” \n\n  \nZOOM registration link \n\nRecording of the session\n\n\nThe RNA Collaborative seminar series goal is to cross-promote RNA research and strengthen and connect the RNA scientific community. These seminars are organized by the RNA Centers of the following institutions: MD Anderson Center for RNA Interference and Non-Coding RNAs; Harvard Medical School Initiative for RNA Medicine; NCI RNA Biology Initiative; RiboClub Sherbrooke; The RNA Institute\, University At Albany; UMass Medical School\, RNA Therapeutics Institute; University of Michigan Center for RNA Biomedicine; University of Rochester Center for RNA Biology; Yale Center for RNA Science and Medicine\, European Molecular Biology Laboratory (EMBL)\, Shanghai RNA Club\, The Bay Area RNA Club (BARC)\, UCSC Center for Molecular Biology of RNA\, and NUS-CSI Singapore RNA Biology Center\, Penn RNA Group\, University of Pennsylvania\, and Helmholtz Institute for RNA-based Infection Research. \n\n \n  \nRNA Collaborative
URL:https://rna.umich.edu/events/rna-collaborative-seminar-series-u-m-center-for-rna-biomedicine-hosting/
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20200921T160000
DTEND;TZID=America/Detroit:20200921T170000
DTSTAMP:20260504T143903
CREATED:20200406T125600Z
LAST-MODIFIED:20200922T162702Z
UID:5139-1600704000-1600707600@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Andrey S. Krasilnikov\, PhD\, Penn State University
DESCRIPTION:“Structures of eukaryotic RNases MRP/P RNPs reveal RNA-driven protein remodeling”\nAndrey Krasilnikov\, Associate Professor of Biochemistry and Molecular Biology\, Center for RNA Biology\, Pennsylvania State University\n \nKeywords: Ribozymes\, RNase P\, RNase MRP\, ribonucleoprotein complexes\, RNA-driven protein remodelling \nZOOM \nREGISTRATION REQUIRED: \nhttps://umich.zoom.us/webinar/register/WN_obckKUCLT4mXI7kPskzc-Q \n  \n \nAbstract: Ribonuclease (RNase) P is a ribozyme-based catalytic ribonucleoprotein complex involved primarily in the maturation of tRNA in all three domains of life. In the course of evolution\, the size and complexity of RNase P grew as the catalytic RNA moiety recruited additional protein components. In eukaryotes\, the RNase P lineage has split\, giving rise to a related RNP enzyme called RNase MRP\, which shares multiple structural features (including most of the protein components) with the eukaryotic RNase P\, but has a distinct and non-overlapping specificity. \nWe report the recently solved cryo-EM structure of the 450 kDa yeast RNase MRP holoenzyme and compare it with the structure of its progenitor RNP\, RNase P. We show that\, surprisingly\, several of the proteins shared by RNase MRP and RNase P undergo RNA-driven structural remodeling\, allowing the same proteins to function in distinct structural contexts. This remodeling\, combined with altered peripheral RNA elements\, results in the functional diversification of the two closely related RNPs\, in spite of the structural conservation of the nearly identical catalytic cores\, demonstrating structural underpinnings of the acquisition of new functions by catalytic RNPs.
URL:https://rna.umich.edu/events/andrey-krasilnikov-penn-state/
LOCATION:Virtual
CATEGORIES:Seminar
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DTSTART;TZID=America/Detroit:20200928T090000
DTEND;TZID=America/Detroit:20200928T100000
DTSTAMP:20260504T143903
CREATED:20200817T170308Z
LAST-MODIFIED:20200922T163039Z
UID:6352-1601283600-1601287200@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Hiroaki Suga\, University of Tokyo
DESCRIPTION:“Genetic code reprogramming that Revolutionizes the discovery processes of peptide drug leads”\n\nHiroaki Suga\, PhD\nProfessor\, Department of Chemistry\, Graduate School of Science\nThe University of Tokyo\, Japan\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_PBHPayAvR8WobaSf3z0AUA \nABSTRACT: Macrocyclic peptides possess a number of pharmacological characteristics distinct from other well-established therapeutic molecular classes\, resulting in a versatile drug modality with a unique profile of advantages. Macrocyclic peptides are accessible by not only chemical synthesis but also ribosomal synthesis. Particularly\, recent inventions of the genetic code reprogramming integrated with an in vitro display format\, referred to as RaPID (Random non-standard Peptides Integrated Discovery) system\, have enabled us to screen mass libraries (>1 trillion members) of non-standard peptides containing multiple non-proteinogenic amino acids\, giving unique properties of peptides distinct from conventional peptides\, e.g. greater proteolytic stability\, higher affinity (low nM to sub nM dissociation constants similar to antibodies)\, and superior pharmacokinetics. The field is rapidly growing evidenced by increasing interests from industrial sectors\, including small start-ups as well as mega-pharmas\, toward drug development efforts on macrocyclic peptides\, which has led to several de novo discovered peptides entering clinical trials. This lecture discusses the aforementioned screening technology involving the method of “genetic code reprogramming” powered by flexizymes\, and several showcases of therapeutic potentials of macrocyclic peptides \nJoin us for a Journal club to prepare for Dr Suga’s seminar\nSeptember 24 @ 4:00 pm – 5:00 pm\nZOOM LINK: https://umich.zoom.us/j/93910966695\nPublication to review:“Ribosomal Formation of Thioamide Bonds in Polypeptide Synthesis” Rumit Maini\, Hiroyuki Kimura\, Ryo Takatsuji\, Takayuki Katoh\, Yuki Goto\, and Hiroaki Suga https://pubs.acs.org/doi/pdf/10.1021/jacs.9b11097 \nRESEARCH INTERESTS: In the Suga lab\, our aim is to utilize organic chemistry techniques in combination with biology to tackle yet unresolved questions. In our inclusive research\, we procure scientific knowledge leading to new concepts and develop novel technologies with broad applicability\, which can extend to drug discovery. We provide a diligent and cooperative research environment with a goal of nurturing individuals so they are brimming with innovation and global-mindedness. \n  \n  \n 
URL:https://rna.umich.edu/events/seminar-hiroaki-suga-university-of-tokyo/
CATEGORIES:Journal Club,Seminar
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