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SUMMARY:RNA Innovation Seminar: Evgeny Nudler\, New York University
DESCRIPTION:“Transcription-driven DNA Repair”\nEvgeny Nudler\, Ph.D.\nJulie Wilson Anderson Professor of Biochemistry\nInvestigator\, Howard Hughes Medical Institute\nDepartment of Biochemistry & Molecular Pharmacology\nNYU Grossman School of Medicine \n  \nIn-person: BSRB\, ABC seminar rooms / hybrid link \nAbstract: Using E. coli as a model system\, we have developed new approaches to study damage recognition and processing in vivo for three major DNA repair pathways\, nucleotide excision repair (NER)\, ribonucleotide excision repair (RER)\, and base excision repair (BER). Our recent findings let us to formulate a conceptually new model of global transcription-driven repair (TDR)\, in which RNA polymerase serves as the indispensable genome-wide DNA damage sensor and also delivery vehicle and platform for the assembly of specialized repair complexes in living cells. The model provides a framework for better understanding genotoxic stress response and genome instability in bacteria and beyond.\nKeywords: DNA repair\, transcription elongation\, RNA polymerase\, ppGpp\, NER\, BER\, RER
URL:https://rna.umich.edu/events/evgeny-nudler/
LOCATION:MI
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