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SUMMARY:RNA Innovation Seminar: Karen Mohlke\, UNC
DESCRIPTION:“Genetic Variant Effects on Adipose Gene Expression and Their Role in Cardiometabolic Traits.”\nKaren Mohlke\, Ph.D.\nProfessor and Associate Chair for Research\nOliver Smithies Investigator\nDepartment of Genetics\, University of North Carolina\nIn-person: BSRB\, ABC seminar rooms / hybrid link \nAbstract: Noncoding genetic variants can affect common diseases and related quantitative traits. Variants may affect the expression levels of transcripts and alternatively-spliced isoforms\, dependent on cell context. I will describe genetic variants associated with adipose tissue gene expression level in >2\,200 people and their putative roles in cardiometabolic disease traits. Similarly\, I will implicate variants associated with splice junction usage in disease risk. Finally\, based on chromatin accessibility during adipocyte differentiation\, I will show genetic regulatory effects that depend on cell context. Together\, these studies help identify regulatory mechanisms for common diseases.\nKeywords: Transcriptome\, expression quantitative trait loci (eQTL)\, splice QTL (sQTL)\, genome-wide association study (GWAS)\, chromatin accessibility\, epigenome\, adipose tissue\, adipocyte.
URL:https://rna.umich.edu/events/karen-mohlke/
LOCATION:MI
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