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DTSTART;TZID=America/Detroit:20210503T160000
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DTSTAMP:20260425T171353
CREATED:20210126T234652Z
LAST-MODIFIED:20210413T174229Z
UID:7841-1620057600-1620061200@rna.umich.edu
SUMMARY:RNA Innovation Seminar: Olivia Rissland\, University of Colorado School of Medicine
DESCRIPTION:“Regulating the Regulators: Control of RNA Binding Proteins during Embryogenesis”\nOlivia Rissland\, Ph.D.\nAssistant Professor\nRNA Bioscience Initiative | Department of Biochemistry & Molecular Genetics\nUniversity of Colorado School of Medicine \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_vA9zYS5nSEenf8Zmt1f-qA \nFLYER IN PDF \n  \nABSTRACT: The maternal-to-zygotic transition (MZT) is a conserved step in animal development\, where control is passed from the maternal to the zygotic genome. Although the MZT is typically considered from its impact on the transcriptome\, we previously found that three maternally deposited Drosophila RNA binding proteins (ME31B\, Trailer Hitch [TRAL]\, and Cup) are also cleared during the MZT by unknown mechanisms. Here\, we show that these proteins are degraded by the ubiquitin-proteasome system. Marie Kondo\, an E2 conjugating enzyme\, and the E3 CTLH ligase are required for the destruction of ME31B\, TRAL\, and Cup. Structure modeling of the Drosophila CTLH complex suggests that substrate recognition is different than orthologous complexes. Despite occurring hours earlier\, egg activation mediates clearance of these proteins through the Pan Gu kinase\, which stimulates translation of Kondo mRNA. Clearance of the maternal protein dowry thus appears to be a coordinated\, but as-yet underappreciated\, aspect of the MZT.
URL:https://rna.umich.edu/events/olivia-rissland/
CATEGORIES:Seminar
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