BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Center for RNA Biomedicine - ECPv6.15.17//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://rna.umich.edu
X-WR-CALDESC:Events for Center for RNA Biomedicine
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Detroit
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20190310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20191103T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20200308T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20201101T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20210314T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20211107T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Detroit:20201207T170000
DTEND;TZID=America/Detroit:20201207T180000
DTSTAMP:20260420T123957
CREATED:20200818T124310Z
LAST-MODIFIED:20201201T223204Z
UID:6372-1607360400-1607364000@rna.umich.edu
SUMMARY:RNA Innovation Seminar: John Mattick\, University of New South Wales\, Sydney\, Australia
DESCRIPTION:RNA at the epicenter of cell and developmental biology\n\nJohn Mattick\, Ph.D.\nProfessor of RNA Biology\nSchool of Biotechnology and Biomolecular Sciences\nUniversity of New South Wales\, Sydney\, Australia\n\n \nZOOM \nREGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_fCIiMkveTdq3D9-PKFLm6Q \nFLYER IN PDF \nABSTRACT: The genomic programming of the development of complex organisms appears to have been misunderstood. The human genome contains just ~20\,000 protein-coding genes\, similar in number and with largely orthologous functions as those in other animals\, including simple nematodes with only 1\,000 somatic cells. By contrast\, the extent of non-protein-coding DNA increases with increasing developmental complexity\, reaching 98.8% in humans. Moreover\, it is now clear that the majority of the genome is not junk but is differentially and dynamically transcribed to produce not only mRNAs but also tens if not hundreds of thousands of short and long non-protein-coding RNAs that show specific expression patterns and subcellular locations. Many of these noncoding RNAs have evolved rapidly under positive selection for adaptive radiation\, and many have been shown to have important roles in development\, brain function\, cancer and other diseases. They function at many different levels of gene expression and cell biology\, including translational control\, formation of subcellular (phase-separated) domains\, and guidance of the epigenetic processes and chromatin dynamics that underpin development\, brain function and physiological adaptation\, with plasticity enabled by RNA editing\, RNA modification and retrotransposon mobilization. These discoveries mean that the assumption that combinatorial control by transcription factors and other regulatory proteins is sufficient to account for human ontogeny is incorrect\, as are the circular assumptions about the neutral evolution of the genome. The challenge now is to determine the structure-function relationships of these RNAs and their mechanisms of action\, as well as their place in the decisional hierarchies that control human development\, physiology\, learning and susceptibility to disorders
URL:https://rna.umich.edu/events/seminar-john-mattick/
CATEGORIES:Seminar
END:VEVENT
END:VCALENDAR